Salvianolic Acid B

INCI: SALVIANOLIC ACID B (NOT UNIVERSALLY LISTED IN COSING AS A STANDARD COSMETIC INCI; MAY BE LISTED AS A COMPONENT OF SALVIA MILTIORRHIZA ROOT EXTRACT)

CAS Number
121521-90-2
Function
Antioxidant, anti-inflammatory (primarily pharmaceutical/nutraceutical use; emerging cosmetic active)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically regulated; no GRAS status. Permitted as a cosmetic ingredient under general safety provisions if adequate safety data exist

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Major flag: This is primarily a pharmaceutical research compound from Salvia miltiorrhiza (Danshen). No CIR review, no SCCS opinion, no established cosmetic use history at scale. If you intend to use this as an isolated active: (1) prepare a full toxicological dossier; (2) conduct dermal penetration study; (3) perform HRIPT at intended use concentration; (4) may trigger Novel Ingredient requirements in some markets. Pharmacological potency (anti-platelet, vasodilatory) is a concern at higher ...

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Concern Level: High

Frequently Asked Questions

Is Salvianolic Acid B safe in cosmetics?

Major flag: This is primarily a pharmaceutical research compound from Salvia miltiorrhiza (Danshen). No CIR review, no SCCS opinion, no established cosmetic use history at scale. If you intend to use this as an isolated active: (1) prepare a full toxicological dossier; (2) conduct dermal penetration study; (3) perform HRIPT at intended use concentration; (4) may trigger Novel Ingredient requirements in some markets. Pharmacological potency (anti-platelet, vasodilatory) is a concern at higher ... The EU classifies Salvianolic Acid B as "permitted". Safety rating: MODERATE.

Is Salvianolic Acid B allowed in the EU?

Salvianolic Acid B EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Salvianolic Acid B do in cosmetics?

Salvianolic Acid B functions as: Antioxidant, anti-inflammatory (primarily pharmaceutical/nutraceutical use; emerging cosmetic active). It is classified as a cosmetic ingredient in our database. CAS number: 121521-90-2.

What is the Margin of Safety for Salvianolic Acid B?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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