NOAEL Studies
Cosmetic Ingredient
Saponins NOAEL Studies
INCI: SAPONINS
CAS: 8047-15-2 (generic saponins); also referenced as CID 6540709
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 200 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=ea6308b6-83d8-4d5f-8b45-6edf5d144b71_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=ea6308b6-83d8-4d5f-8b45-6edf5d144b71/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1974; key_result=false; entry_uuid=2ae8d15c-4df8-4439-aaf4-575223831956 |
| ECHA | LOAEL | 200 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=ea6308b6-83d8-4d5f-8b45-6edf5d144b71_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=ea6308b6-83d8-4d5f-8b45-6edf5d144b71/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1974; key_result=false; entry_uuid=2ae8d15c-4df8-4439-aaf4-575223831956 |
| ECHA | LOAEL | 200 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=ea6308b6-83d8-4d5f-8b45-6edf5d144b71_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=ea6308b6-83d8-4d5f-8b45-6edf5d144b71/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1974; key_result=false; entry_uuid=2ae8d15c-4df8-4439-aaf4-575223831956 |
| ECHA | NOAEL | 400 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=ea6308b6-83d8-4d5f-8b45-6edf5d144b71_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=ea6308b6-83d8-4d5f-8b45-6edf5d144b71/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=false; entry_uuid=0ddb8ea8-503e-47e7-b1b2-b032d8c5fa63 |
| ECHA | NOAEL | 1175 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=2db686d7-5793-4a40-bcba-8c9c40150dd0_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=2db686d7-5793-4a40-bcba-8c9c40150dd0/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; key_result=false; entry_uuid=754b8265-cc42-4818-a8c8-53980ebe6cd7 |
| ECHA | NOAEL | 1500 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=2db686d7-5793-4a40-bcba-8c9c40150dd0_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=2db686d7-5793-4a40-bcba-8c9c40150dd0/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; key_result=false; entry_uuid=8c872fc0-884e-47c7-86b7-dec28dcb9919 |
| ECHA | NOAEL | 700 | mg/kg bw/day | mouse | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=af9e96af-58ba-4857-82a4-3eec4f19ebe2_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=af9e96af-58ba-4857-82a4-3eec4f19ebe2/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; key_result=false; entry_uuid=48600287-41cc-4b26-ae88-a1c66d8dfff5 |
| ECHA | NOAEL | 400 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=ea6308b6-83d8-4d5f-8b45-6edf5d144b71_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=ea6308b6-83d8-4d5f-8b45-6edf5d144b71/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=false; entry_uuid=0ddb8ea8-503e-47e7-b1b2-b032d8c5fa63 |
| ECHA | NOAEL | 1175 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=2db686d7-5793-4a40-bcba-8c9c40150dd0_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=2db686d7-5793-4a40-bcba-8c9c40150dd0/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; key_result=false; entry_uuid=754b8265-cc42-4818-a8c8-53980ebe6cd7 |
| ECHA | NOAEL | 1500 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=2db686d7-5793-4a40-bcba-8c9c40150dd0_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=2db686d7-5793-4a40-bcba-8c9c40150dd0/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; key_result=false; entry_uuid=8c872fc0-884e-47c7-86b7-dec28dcb9919 |
| ECHA | NOAEL | 700 | mg/kg bw/day | mouse | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=af9e96af-58ba-4857-82a4-3eec4f19ebe2_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=af9e96af-58ba-4857-82a4-3eec4f19ebe2/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; key_result=false; entry_uuid=48600287-41cc-4b26-ae88-a1c66d8dfff5 |
| ECHA | NOAEL | 400 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=ea6308b6-83d8-4d5f-8b45-6edf5d144b71_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=ea6308b6-83d8-4d5f-8b45-6edf5d144b71/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=false; entry_uuid=0ddb8ea8-503e-47e7-b1b2-b032d8c5fa63 |
| ECHA | NOAEL | 1175 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=2db686d7-5793-4a40-bcba-8c9c40150dd0_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=2db686d7-5793-4a40-bcba-8c9c40150dd0/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; key_result=false; entry_uuid=754b8265-cc42-4818-a8c8-53980ebe6cd7 |
| ECHA | NOAEL | 1500 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=2db686d7-5793-4a40-bcba-8c9c40150dd0_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=2db686d7-5793-4a40-bcba-8c9c40150dd0/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; key_result=false; entry_uuid=8c872fc0-884e-47c7-86b7-dec28dcb9919 |
| ECHA | NOAEL | 700 | mg/kg bw/day | mouse | oral: feed | - | chronic toxicity: oral | dossier=8964a804-e912-4e85-a6c4-daeec1f88782.i6z; document=af9e96af-58ba-4857-82a4-3eec4f19ebe2_8964a804-e912-4e85-a6c4-daeec1f88782.i6d; document_key=af9e96af-58ba-4857-82a4-3eec4f19ebe2/8964a804-e912-4e85-a6c4-daeec1f88782; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; key_result=false; entry_uuid=48600287-41cc-4b26-ae88-a1c66d8dfff5 |