Good Cosmetic Ingredient

Sarsasapogenin

INCI: SARSASAPOGENIN [^1_13]

CAS Number
126-19-2 [^1_12]
Function
Skin conditioning; lipogenic/adipogenic activity (promotes subcutaneous adipose tissue formation, lipid synthesis in epidermis) [^1_13][^1_14]
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status restricted
US Notes Not specifically restricted; no CIR monograph; patent literature supports cosmetic use (L'Oréal/Sederma patents) [^1_14]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Steroidal structure — verify no estrogenic cross-reactivity at use concentrations; adipogenic activity means it actively modifies tissue biology (lipofilling effect); not a passive cosmetic ingredient; ensure concentration is appropriate for cosmetic (not pharmaceutical) claims; optical rotation [α]D = −75° (c 0.5, CHCl₃) — verify identity/purity via this parameter [^1_12][^1_14]

⚠️
Concern Level: Low

Frequently Asked Questions

Is Sarsasapogenin safe in cosmetics?

Steroidal structure — verify no estrogenic cross-reactivity at use concentrations; adipogenic activity means it actively modifies tissue biology (lipofilling effect); not a passive cosmetic ingredient; ensure concentration is appropriate for cosmetic (not pharmaceutical) claims; optical rotation [α]D = −75° (c 0.5, CHCl₃) — verify identity/purity via this parameter [^1_12][^1_14] The EU classifies Sarsasapogenin as "permitted". Safety rating: GOOD.

Is Sarsasapogenin allowed in the EU?

Sarsasapogenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sarsasapogenin do in cosmetics?

Sarsasapogenin functions as: Skin conditioning; lipogenic/adipogenic activity (promotes subcutaneous adipose tissue formation, lipid synthesis in epidermis) [^1_13][^1_14]. It is classified as a cosmetic ingredient in our database. CAS number: 126-19-2 [^1_12].

What is the Margin of Safety for Sarsasapogenin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Sarsasapogenin compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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