Sassafras Officinale Root Oil

INCI: SASSAFRAS OFFICINALE ROOT OIL

CAS Number
8006-80-2 [^1_10]
Function
Fragrance, Skin Conditioning [^1_10]
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Banned โ€” FDA prohibited sassafras oil and safrole in food/drugs; cosmetic use extremely restricted [^1_7][^1_8]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

DO NOT FORMULATE โ€” ~80% safrole (carcinogen 1B); controlled substance/narcotic precursor in EU; cannot realistically meet 100 ppm limit in finished product; hepatocarcinogenic in animal models [^1_6]

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Concern Level: High

Regulatory Flags

plant-oil fragrance-component

Frequently Asked Questions

Is Sassafras Officinale Root Oil safe in cosmetics?

DO NOT FORMULATE โ€” ~80% safrole (carcinogen 1B); controlled substance/narcotic precursor in EU; cannot realistically meet 100 ppm limit in finished product; hepatocarcinogenic in animal models [^1_6] The EU classifies Sassafras Officinale Root Oil as "prohibited". Safety rating: POOR.

Is Sassafras Officinale Root Oil allowed in the EU?

Sassafras Officinale Root Oil EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Sassafras Officinale Root Oil do in cosmetics?

Sassafras Officinale Root Oil functions as: Fragrance, Skin Conditioning [^1_10]. It is classified as a cosmetic ingredient in our database. CAS number: 8006-80-2 [^1_10].

What is the Margin of Safety for Sassafras Officinale Root Oil?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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