NOAEL Studies Cosmetic Ingredient

Sec-Butyl Alcohol NOAEL Studies

INCI: SEC-BUTYL ALCOHOL (2-BUTANOL)

CAS: 78-92-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1644 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1771 mg/kg bw/day rat oral 21 day Reproductive-developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 24.2378 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5031; Record_ID=acute_inhalation_1762; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9021762; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=24.2378; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021762
NTP_ICE_acute_inhalation LC50 48.5 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5032; Record_ID=acute_inhalation_1763; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9021762; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=48.5; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021762
NTP_ICE_acute_oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2054 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_10322; row=15431; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butanol; preferred_name=2-Butanol; dtxsid=DTXSID9021762; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021762; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2328 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_10326; row=15432; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butanol; preferred_name=2-Butanol; dtxsid=DTXSID9021762; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021762; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6480 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10327; row=15433; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butanol; preferred_name=2-Butanol; dtxsid=DTXSID9021762; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021762; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2193 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10324; row=15434; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butanol; preferred_name=2-Butanol; dtxsid=DTXSID9021762; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021762; source_file=acute_oral.xlsx
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =51537.7 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=DOE Protective Action Criteria:15513039:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1987de4bcd9a1e639f47fc205e0f86d8
ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =48506.1 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14353/7/3/3?documentUUID=e2e1cd3f-2a56-4400-8e0f-5f8b7ade7ad8; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15798535:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e688541ec2f0012cdf776c73c0d018d
ToxValDB_ECHA_IUCLID LOAEC =10610.7 mg/m3 Rat inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d198e4b0a7c65d22f33d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20497/7/9/3?documentUUID=80bc0980-5fdf-40d2-9c9b-45a33204f4c6; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822383_15823179:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89711f6ee7578d82469f4ef827098636
ToxValDB_ECHA_IUCLID LOAEL =20000 mg/L Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95de4b0a7c65d21c8a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14353/7/9/2?documentUUID=e2e1cd3f-2a56-4400-8e0f-5f8b7ade7ad8; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855874_15856614:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15a9e2a1cae1e1388ed3a809d8a984e0
ToxValDB_ECHA_IUCLID NOAEC =10610.7 mg/m3 Rat inhalation - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d198e4b0a7c65d22f33d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20497/7/9/3?documentUUID=80bc0980-5fdf-40d2-9c9b-45a33204f4c6; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID:15821058:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b7ef80ad3bae4ab5745bc201d199ef08
ToxValDB_ECHA_IUCLID NOAEL >480 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf17c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14353/7/9/3?documentUUID=e2e1cd3f-2a56-4400-8e0f-5f8b7ade7ad8; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15821213:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a2c212e9ab0ba2d3658378a999385a01
ToxValDB_ECHA_IUCLID NOAEL =10000 mg/L Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d231e4b0a7c65d231e82; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14353/7/9/3?documentUUID=e2e1cd3f-2a56-4400-8e0f-5f8b7ade7ad8; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15822488:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04176e04445fb9158d23a8bec6b65c45
ToxValDB_ECHA_IUCLID NOEC =15158.2 mg/m3 Rat inhalation - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d2178b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14353/7/8?documentUUID=e2e1cd3f-2a56-4400-8e0f-5f8b7ade7ad8; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15817149:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_834d76600c0058c97358331de90d993e
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =600 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630363:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b269e018918b97162530944bc9a8f61
ToxValDB_PPRTV_(CPHEA) 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) BMDL (05) =657 mg/kg bw/day Rat oral chronic (developmental) reproduction developmental LONG_REF=Cox et al. 1975; AUTHOR=Cox et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1613; TOXICOLOGICAL_EFFECT=reduced pup body weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=PPRTV (CPHEA):15654094:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9bb043bfb911f04fcff5c24aa2ce8195
ToxValDB_PPRTV_(CPHEA) NOAEL (HEC) =3093 mg/m3 Rat inhalation short-term (developmental); 19 days developmental LONG_REF=Nelson et al. 1989; AUTHOR=Nelson et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1613; TOXICOLOGICAL_EFFECT=reduced fetal body weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=PPRTV (CPHEA):15653837:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c496a2a446a662c35decfb1260fcdeb
ToxValDB_PPRTV_(CPHEA) RfC (provisional) =30 mg/m3 Human inhalation - Toxicity Value LONG_REF=Nelson et al. 1989; AUTHOR=Nelson et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1613; TOXICOLOGICAL_EFFECT=Reduced fetal body weight in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653835_15653836:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_54948fd59cc3395850da3ccc9c086b97
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =2 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Cox et al. 1975; AUTHOR=Cox et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1613; TOXICOLOGICAL_EFFECT=Decreased pup body weight in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653815_15653816:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_16806a36cdfee29e73435af42c34ecc0
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0TUL3ENK62 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0TUL3ENK62"}
openFDA substances FDA UNII substance identifier 0TUL3ENK62 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0TUL3ENK62"}
openFDA substances FDA UNII substance identifier 0TUL3ENK62 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0TUL3ENK62"}
openFDA substances FDA UNII substance identifier 0TUL3ENK62 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0TUL3ENK62"}