Sesamidopropyl Betaine

INCI: SESAMIDOPROPYL BETAINE [^1_11]

CAS Number
Not individually assigned; structural analog of cocamidopropyl betaine (CAS 61789-40-0) [^1_10]
Function
Skin conditioning; surfactant – cleansing; surfactant – foam boosting; viscosity controlling [^1_11]
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted for cosmetic use; MoS >100 for CAPB analog at ≤6% leave-on and ≤30% rinse-off [^1_10]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Monitor DMAPA and amidoamine impurities — these are the true sensitizers in amphoteric betaine systems, not the betaine itself [^1_10]

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Sesamidopropyl Betaine safe in cosmetics?

Monitor DMAPA and amidoamine impurities — these are the true sensitizers in amphoteric betaine systems, not the betaine itself [^1_10] The EU classifies Sesamidopropyl Betaine as "permitted". Safety rating: GOOD.

Is Sesamidopropyl Betaine allowed in the EU?

Sesamidopropyl Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sesamidopropyl Betaine do in cosmetics?

Sesamidopropyl Betaine functions as: Skin conditioning; surfactant – cleansing; surfactant – foam boosting; viscosity controlling [^1_11]. It is classified as a cosmetic ingredient in our database. CAS number: Not individually assigned; structural analog of cocamidopropyl betaine (CAS 61789-40-0) [^1_10].

What is the Margin of Safety for Sesamidopropyl Betaine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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