SH-Pentapeptide-2

INCI: SH-PENTAPEPTIDE-2

CAS Number
Not publicly assigned (CosIng entry exists without CAS)
Function
Skin conditioning; described as "a single chain human peptide, produced synthetically to be identical to a portion of the protein"
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA monograph; MoCRA self-assessment applies

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No independent safety review. CosIng description is vague about the parent protein identity

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Concern Level: Moderate

Frequently Asked Questions

Is SH-Pentapeptide-2 safe in cosmetics?

No independent safety review. CosIng description is vague about the parent protein identity The EU classifies SH-Pentapeptide-2 as "permitted". Safety rating: MODERATE.

Is SH-Pentapeptide-2 allowed in the EU?

SH-Pentapeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does SH-Pentapeptide-2 do in cosmetics?

SH-Pentapeptide-2 functions as: Skin conditioning; described as "a single chain human peptide, produced synthetically to be identical to a portion of the protein". It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (CosIng entry exists without CAS).

What is the Margin of Safety for SH-Pentapeptide-2?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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