Is SH-Pentapeptide-2 safe in cosmetics?
SH-Pentapeptide-2 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
SH-Pentapeptide-2
INCI: SH-PENTAPEPTIDE-2
SH-Pentapeptide-2 (CAS Not publicly assigned (CosIng entry exists without CAS)) is a cosmetic cosmetic ingredient functioning as Skin conditioning; described as "a single chain human peptide, produced. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
CAS Number
Not publicly assigned (CosIng entry exists without CAS)
View industrial chemical safety profile →
Function
Skin conditioning; described as "a single chain human peptide, produced synthetically to be identical to a portion of the protein"
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA monograph; MoCRA self-assessment applies
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for SH-Pentapeptide-2.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for SH-Pentapeptide-2 — not a computed safety verdict. See the sourced toxicological data above.
Frequently Asked Questions
Is SH-Pentapeptide-2 allowed in the EU?
SH-Pentapeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SH-Pentapeptide-2 do in cosmetics?
SH-Pentapeptide-2 functions as: Skin conditioning; described as "a single chain human peptide, produced synthetically to be identical to a portion of the protein". It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (CosIng entry exists without CAS).
Compliance Tools
Check SH-Pentapeptide-2 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Is SH-Pentapeptide-2 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for SH-Pentapeptide-2 in your formulation.