Good Cosmetic Ingredient

sh-Polypeptide-22

INCI: SH-POLYPEPTIDE-22

CAS Number
Not publicly assigned (no CAS listed in CosIng/PCPC)
Function
Skin conditioning; recombinant analog of human TGFβ-1 (Transforming Growth Factor Beta 1) — stimulates collagen/elastin/fibronectin synthesis, anti-inflammatory, brightening
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted cosmetic ingredient (PCPC/INCI listed); no specific FDA restriction; manufacturer responsible for safety under FDCA/MoCRA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Growth factor analog — theoretical concern about promoting abnormal cell proliferation on compromised/damaged skin; not recommended on open wounds in cosmetic use context; no Annex restriction applied by EU

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Concern Level: Low

Frequently Asked Questions

Is sh-Polypeptide-22 safe in cosmetics?

Growth factor analog — theoretical concern about promoting abnormal cell proliferation on compromised/damaged skin; not recommended on open wounds in cosmetic use context; no Annex restriction applied by EU The EU classifies sh-Polypeptide-22 as "restricted". Safety rating: GOOD.

Is sh-Polypeptide-22 allowed in the EU?

sh-Polypeptide-22 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does sh-Polypeptide-22 do in cosmetics?

sh-Polypeptide-22 functions as: Skin conditioning; recombinant analog of human TGFβ-1 (Transforming Growth Factor Beta 1) — stimulates collagen/elastin/fibronectin synthesis, anti-inflammatory, brightening. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (no CAS listed in CosIng/PCPC).

What is the Margin of Safety for sh-Polypeptide-22?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check sh-Polypeptide-22 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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