Is sh-Polypeptide-22 safe in cosmetics?
sh-Polypeptide-22 has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
sh-Polypeptide-22
INCI: SH-POLYPEPTIDE-22
sh-Polypeptide-22 (CAS Not publicly assigned (no CAS listed in CosIng/PCPC)) is a cosmetic cosmetic ingredient functioning as Skin conditioning; recombinant analog of human TGFβ-1 (Transforming Growth. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
Not publicly assigned (no CAS listed in CosIng/PCPC)
View industrial chemical safety profile →
Function
Skin conditioning; recombinant analog of human TGFβ-1 (Transforming Growth Factor Beta 1) — stimulates collagen/elastin/fibronectin synthesis, anti-inflammatory, brightening
Safety Rating
GOOD
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted cosmetic ingredient (PCPC/INCI listed); no specific FDA restriction; manufacturer responsible for safety under FDCA/MoCRA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for sh-Polypeptide-22.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for sh-Polypeptide-22.
Frequently Asked Questions
Is sh-Polypeptide-22 allowed in the EU?
sh-Polypeptide-22 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Polypeptide-22 do in cosmetics?
sh-Polypeptide-22 functions as: Skin conditioning; recombinant analog of human TGFβ-1 (Transforming Growth Factor Beta 1) — stimulates collagen/elastin/fibronectin synthesis, anti-inflammatory, brightening. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (no CAS listed in CosIng/PCPC).
Compliance Tools
Check sh-Polypeptide-22 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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