sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination)

INCI: SH-POLYPEPTIDE-7 SH-POLYPEPTIDE-94 SH-POLYPEPTIDE-95 (LISTED AS COMBINATION)

CAS Number
Not assigned (recombinant peptide blend — no individual CAS registered in CosIng)
Function
Skin conditioning, skin protecting, humectant, hair conditioning
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes No specific FDA restriction; permitted in cosmetics under FDCA general provisions. No CIR final safety assessment specific to this combination

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mimics hGH activity — theoretical concern about growth factor signaling at high concentrations; no evidence of systemic effects at cosmetic use levels. No SCCS opinion available

⚠️
Concern Level: Low

Frequently Asked Questions

Is sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination) safe in cosmetics?

Mimics hGH activity — theoretical concern about growth factor signaling at high concentrations; no evidence of systemic effects at cosmetic use levels. No SCCS opinion available The EU classifies sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination) as "restricted". Safety rating: GOOD.

Is sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination) allowed in the EU?

sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination) do in cosmetics?

sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination) functions as: Skin conditioning, skin protecting, humectant, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (recombinant peptide blend — no individual CAS registered in CosIng).

What is the Margin of Safety for sh-Polypeptide-7 / sh-Polypeptide-94 / sh-Polypeptide-95 (Combination)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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