sh-Polypeptide-71

INCI: SH-POLYPEPTIDE-71 (FORMERLY SH-POLYPEPTIDE-65)

CAS Number
Not publicly assigned (not listed in CosIng CAS field)
Function
Hair conditioning, skin conditioning; controls vasodilatation, soothes inflammation, improves angiogenesis
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific restriction; general cosmetic use permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Vasoactive peptide โ€” controls vasodilatation and angiogenesis. Useful for dark circles/puffiness but theoretically could affect vascular function if absorbed systemically. Used for contact dermatitis and psoriasis treatment โ€” implies pharmaceutical-grade activity

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Concern Level: Moderate

Frequently Asked Questions

Is sh-Polypeptide-71 safe in cosmetics?

Vasoactive peptide โ€” controls vasodilatation and angiogenesis. Useful for dark circles/puffiness but theoretically could affect vascular function if absorbed systemically. Used for contact dermatitis and psoriasis treatment โ€” implies pharmaceutical-grade activity The EU classifies sh-Polypeptide-71 as "permitted". Safety rating: MODERATE.

Is sh-Polypeptide-71 allowed in the EU?

sh-Polypeptide-71 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does sh-Polypeptide-71 do in cosmetics?

sh-Polypeptide-71 functions as: Hair conditioning, skin conditioning; controls vasodilatation, soothes inflammation, improves angiogenesis. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (not listed in CosIng CAS field).

What is the Margin of Safety for sh-Polypeptide-71?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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