NOAEL Studies
Cosmetic Ingredient
Sodium C14-18 Olefin Sulfonate NOAEL Studies
INCI: SODIUM C14-18 OLEFIN SULFONATE
CAS: 68439-57-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =70 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb98e4b0a7c65d226ca0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/6/2?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15849730:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e067ef24a1033fce7efc594a8108c45 |
| ECHA | NOAEL | =2 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1f9e4b0a7c65d2310a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/9/3?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15823244:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_065a0889f9d7a666cd7cec1703c8ff9f |
| ECHA | NOAEL | >=16.34 | mg/kg bw/day | Rat | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d21715b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/8?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817071_15817072:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c731745c3243991089b25bceee741612 |
| ECHA | NOAEL | >=42 | mg/kg bw/day | Rat | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d21715b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/8?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817071_15817072:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72f6c059c7eb81ddb27efb2938cee011 |
| ECHA | NOAEL | >=126 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217163; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/8?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818932_15818933:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c27dd7ffe327c60f9601f0f66285ee94 |
| ECHA | NOAEL | >=157.5 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217163; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/8?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818932_15818933:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b175ec56cbdcd2179fa94ba663dc959 |
| ECHA | NOAEL | >=195 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217145; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/8?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15820523:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4e1547982f4b385d77e73eafa012d79 |
| ECHA | NOAEL | >=259 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217145; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/8?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15820524:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4f7067f1af8e0c93c78a1693acfa4f86 |
| ECHA | NOAEL | >=375 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d21714b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/8?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15820525:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b1491b1173eea13da60fd86770e256a2 |
| ECHA | NOAEL | >=600 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1f9e4b0a7c65d2310aa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/9/3?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15825084:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_205dae74e79bd2e8e9446bb7a416d023 |
| ECHA | NOEL | =96 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb98e4b0a7c65d226cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/6/2?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839403_15849732:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_95dc52f433d57c6d95d8a35627552857 |
| ECHA | NOEL | =132 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb98e4b0a7c65d226cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16004/7/6/2?documentUUID=427e8d80-e37c-47c9-b91c-07ad0f2ddace; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839404_15849731:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4dbb6ea11aab455437927c951cd67b0a |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =152.22 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b7d7e3dc73c1654f0264273d40b599f |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | O9W3D3YF5U | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"O9W3D3YF5U"} |
| openFDA substances | FDA UNII substance identifier | O9W3D3YF5U | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"O9W3D3YF5U"} |
| openFDA substances | FDA UNII substance identifier | O9W3D3YF5U | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"O9W3D3YF5U"} |
| openFDA substances | FDA UNII substance identifier | O9W3D3YF5U | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"O9W3D3YF5U"} |