Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sodium C16-20 Alkyl Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 1.13 other | oral | rat | oral | REACH |
| NOAEL | 10 other | dermal | code:3543 | dermal | REACH |
| NOAEL | 0.56 other | oral | - | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=430 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 201.28 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 460 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 1.5 other | oral | rat | oral | REACH |
| NOAEL | 512 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 482 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Like all alkyl sulfates, can be drying/irritating at elevated concentrations. Prolonged skin contact formulations should limit concentrations per SLS-class precedent (≤1% for extended contact)
Frequently Asked Questions
Is Sodium C16-20 Alkyl Sulfate safe in cosmetics?
Like all alkyl sulfates, can be drying/irritating at elevated concentrations. Prolonged skin contact formulations should limit concentrations per SLS-class precedent (≤1% for extended contact) The EU classifies Sodium C16-20 Alkyl Sulfate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Sodium C16-20 Alkyl Sulfate allowed in the EU?
Sodium C16-20 Alkyl Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium C16-20 Alkyl Sulfate do in cosmetics?
Sodium C16-20 Alkyl Sulfate functions as: Emulsifier, foaming agent, surfactant (cleansing). It is classified as a cosmetic ingredient in our database. CAS number: 91648-55-4.
What is the Margin of Safety for Sodium C16-20 Alkyl Sulfate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium C16-20 Alkyl Sulfate?
The NOAEL (No Observed Adverse Effect Level) for Sodium C16-20 Alkyl Sulfate is 1.13 other based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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