Sodium Histidyl Hyaluronate Crosspolymer-3

INCI: SODIUM HISTIDYL HYALURONATE CROSSPOLYMER-3

CAS Number
Not individually assigned (novel crosslinked HA derivative)
Function
Humectant, Skin Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; no specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel ingredient โ€” limited independent safety studies. Histidine conjugation adds amino acid functionality; verify that the crosslinking agent and residual monomers are characterized. Biotechnology/synthetic origin โ€” confirm GMO-free sourcing if needed for COSMOS/ECOCERT

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Concern Level: Low

Frequently Asked Questions

Is Sodium Histidyl Hyaluronate Crosspolymer-3 safe in cosmetics?

Novel ingredient โ€” limited independent safety studies. Histidine conjugation adds amino acid functionality; verify that the crosslinking agent and residual monomers are characterized. Biotechnology/synthetic origin โ€” confirm GMO-free sourcing if needed for COSMOS/ECOCERT The EU classifies Sodium Histidyl Hyaluronate Crosspolymer-3 as "permitted". Safety rating: GOOD.

Is Sodium Histidyl Hyaluronate Crosspolymer-3 allowed in the EU?

Sodium Histidyl Hyaluronate Crosspolymer-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Histidyl Hyaluronate Crosspolymer-3 do in cosmetics?

Sodium Histidyl Hyaluronate Crosspolymer-3 functions as: Humectant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not individually assigned (novel crosslinked HA derivative).

What is the Margin of Safety for Sodium Histidyl Hyaluronate Crosspolymer-3?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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