Good Cosmetic Ingredient NOAEL Data

Sodium Isostearoyl Lactylate

INCI: SODIUM ISOSTEAROYL LACTYLATE

CAS Number
66988-04-3
Function
Emulsifier, skin conditioning agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; CIR reviewed alkanoyl lactyl lactate salts—safe in present practices when formulated to be nonirritating and nonsensitizing

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Sodium Isostearoyl Lactylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2641 mg/kg bw/day oral rat oral REACH
NOAEL 2641 mg/kg bw/day oral - oral REACH
NOAEL ca.250 mg/kg bw/day oral rat oral REACH
NOAEL ca.250 mg/kg bw/day oral - oral REACH

Expert Verdict

Must be formulated to be nonirritating; potential mild irritation at higher concentrations, particularly near eyes

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Sodium Isostearoyl Lactylate safe in cosmetics?

Must be formulated to be nonirritating; potential mild irritation at higher concentrations, particularly near eyes The EU classifies Sodium Isostearoyl Lactylate as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Sodium Isostearoyl Lactylate allowed in the EU?

Sodium Isostearoyl Lactylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Isostearoyl Lactylate do in cosmetics?

Sodium Isostearoyl Lactylate functions as: Emulsifier, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 66988-04-3.

What is the Margin of Safety for Sodium Isostearoyl Lactylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Isostearoyl Lactylate?

The NOAEL (No Observed Adverse Effect Level) for Sodium Isostearoyl Lactylate is 2641 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

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