Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Sodium Nitrite

INCI: SODIUM NITRITE

CAS Number
7632-00-0
Function
Anticorrosive
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics with restrictions; recognized as corrosion inhibitor

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Sodium Nitrite. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 160 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 500 mg/kg bw/day oral mouse Subchronic COSMOS_DB
NOAEL 250 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 250 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 100 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 50 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 250 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 200 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 254 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes. The substance may cause effects on the cardiovascular system and blood. This may result in lower blood pressure and the formation of methaemoglobin. Exposure could cause death. The effects may be delayed. Medical observation is indicated.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

Critical: Must NOT be combined with amines or aminoamides to prevent nitrosamine formation (potent carcinogens); EU Annex III restrictions are strict; maximum nitrosamine impurity <50 ppb; keep pH controlled

⚠️
Concern Level: High

Regulatory Flags

endocrine_disruptor fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Sodium Nitrite safe in cosmetics?

Critical: Must NOT be combined with amines or aminoamides to prevent nitrosamine formation (potent carcinogens); EU Annex III restrictions are strict; maximum nitrosamine impurity <50 ppb; keep pH controlled The EU classifies Sodium Nitrite as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is Sodium Nitrite allowed in the EU?

Sodium Nitrite EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Nitrite do in cosmetics?

Sodium Nitrite functions as: Anticorrosive. It is classified as a cosmetic ingredient in our database. CAS number: 7632-00-0.

What is the Margin of Safety for Sodium Nitrite?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Nitrite?

The NOAEL (No Observed Adverse Effect Level) for Sodium Nitrite is 100 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Sodium Nitrite compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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