Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sodium Propionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1860 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5600 mg/kg bw/day | oral | sheep | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 4000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1283 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 1025 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 4250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 1860 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 5600 mg/kg bw/day | oral | sheep | Short Term Toxicity | COSMOS_DB |
| dose_tested | 4000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Antimicrobial efficacy is pH-dependent (works best in acidic conditions); not on EU Annex V positive preservative list — if used as the primary preservative, regulatory justification may be challenged
Regulatory Flags
Frequently Asked Questions
Is Sodium Propionate safe in cosmetics?
Antimicrobial efficacy is pH-dependent (works best in acidic conditions); not on EU Annex V positive preservative list — if used as the primary preservative, regulatory justification may be challenged The EU classifies Sodium Propionate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Sodium Propionate allowed in the EU?
Sodium Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Propionate do in cosmetics?
Sodium Propionate functions as: Preservative (antifungal), buffering agent; strong inhibition of molds and gram-negative bacilli in acidic media. It is classified as a cosmetic ingredient in our database. CAS number: 137-40-6.
What is the Margin of Safety for Sodium Propionate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Propionate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Propionate is 1860 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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