NOAEL Studies Cosmetic Ingredient

Sodium Pyrithione NOAEL Studies

INCI: SODIUM PYRITHIONE

CAS: 3811-73-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

NTP_ICE_endocrine 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 12.7840469261165 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=14342; RecordID=ERPathway2016_138; DatasetName=ERPathway2016; DTXSID=DTXSID3042390; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=12.7840469261165; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3042390
NTP_ICE_endocrine ACC 13.9435901122095 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=14343; RecordID=ERPathway2016_138; DatasetName=ERPathway2016; DTXSID=DTXSID3042390; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=13.9435901122095; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3042390
NTP_ICE_endocrine Model Score 0.001 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14338; RecordID=ARPathway2016_1182; DatasetName=ARPathway2016; DTXSID=DTXSID3042390; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.001; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3042390
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=14339; RecordID=ARPathway2016_1182; DatasetName=ARPathway2016; DTXSID=DTXSID3042390; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3042390
NTP_ICE_endocrine Model Score 0.00872 unitless - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14345; RecordID=ERPathway2016_138; DatasetName=ERPathway2016; DTXSID=DTXSID3042390; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.00872; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3042390
ToxValDB_ECHA_IUCLID 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =15 mg/kg bw/day Rat dermal subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61df9e4b096bca8777d17; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/4?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826361_15826362:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3638bf9cc3c86cc22ea6e823eb73b0c4
ToxValDB_ECHA_IUCLID LOAEL =8.1 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/3?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827158_15827159:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89e165dd1beeeb149b6746e24fcaff9f
ToxValDB_ECHA_IUCLID LOAEL =75 mg/kg bw/day Monkey oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb23e4b0a7c65d224fbf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834131_15846858_15846859:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_867c7c682b7cee23cc196d72421f312b
ToxValDB_ECHA_IUCLID LOAEL =1.5 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c3492; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834861_15842073_15850686_15850687:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_61a51ba56904cb8d356f04ae3191c8f0
ToxValDB_ECHA_IUCLID LOAEL =2.5 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae36e4b0a7c65d1c8005; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839971_15839972_15839973_15842173_15847351_15848586:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3d5c11677fc6558b9157da2f4c04e0fb
ToxValDB_ECHA_IUCLID LOAEL =2 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae36e4b0a7c65d1c800b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839971_15839972_15839973_15842173_15847351_15848586:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f98e3a353c521b82e5f24c61177821b9
ToxValDB_ECHA_IUCLID LOAEL =3.5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8290; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/9/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855063_15860853_15861273:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a4c755305eb78355bad28e419342891
ToxValDB_ECHA_IUCLID LOAEL =2.8 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8292; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/9/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855547_15860942_15861073:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e203fc7b72801a6f22deb666f8a7e8bd
ToxValDB_ECHA_IUCLID LOAEL =1.4 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8292; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/9/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856350_15860958_15861822:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73c62c87a485f450644970448c2ef666
ToxValDB_ECHA_IUCLID LOEL =0.1 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae36e4b0a7c65d1c8005; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839971_15839972_15839973_15842173_15847351_15848586:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7416550702ed04508ec444b7d842a805
ToxValDB_ECHA_IUCLID NOAEL =5 mg/kg bw/day Rabbit dermal - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dbe4b0a7c65d230685; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/9/3?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15820824:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f21ad32abb1978363f4e9bf8ab23d7a
ToxValDB_ECHA_IUCLID NOAEL =0.46 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/3?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827158_15827159:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bbb6a74aee43c94073aee5bf01b89c64
ToxValDB_ECHA_IUCLID NOAEL <25 mg/kg bw/day Monkey oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb23e4b0a7c65d224fbf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834131_15846858_15846859:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5dc6e9ff9f4e2b127a7e2c389d17a2eb
ToxValDB_ECHA_IUCLID NOAEL =0.5 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae36e4b0a7c65d1c800b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839971_15839972_15839973_15842173_15847351_15848586:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b955c78a1dacef73b34fa689898b498f
ToxValDB_ECHA_IUCLID NOAEL =0.7 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8292; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/9/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856350_15860958_15861822:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d615c31ab0f0216af64aa186910efdec
ToxValDB_ECHA_IUCLID NOAEL =1.4 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8292; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/9/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861033_15862267:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d8efef410f4c67bdeed3d857ded340c0
ToxValDB_ECHA_IUCLID NOAEL =1.5 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6658; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/9/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861587_15862045:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ff2602f3b3da6ad2d5ae62e765f91c05
ToxValDB_ECHA_IUCLID NOAEL =3.5 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8290; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/9/2?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861707_15861883:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f85dce833530aa01a8bdd2a0daeb7c44
ToxValDB_ECHA_IUCLID NOEL =5 mg/kg bw/day Mouse dermal chronic; 80 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e2ae4b096bca87788f0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/4?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826414_15826415:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9a7ff9fb549af46927b6c785eaf14b8
ToxValDB_ECHA_IUCLID NOEL =15 mg/kg bw/day Mouse dermal chronic; 80 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e2ae4b096bca87788f0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20845/7/6/4?documentUUID=78db9463-9d7e-4013-ba3f-934f9500b29a; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826414_15826415:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8668c58b9fe819e5be0e3357b157fad2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6L3991491R UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H4NOS.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3991491R"}
openFDA substances FDA UNII substance identifier 6L3991491R UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H4NOS.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3991491R"}
openFDA substances FDA UNII substance identifier 6L3991491R UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H4NOS.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3991491R"}
openFDA substances FDA UNII substance identifier 6L3991491R UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H4NOS.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3991491R"}