Soluble Fibroin

INCI: SOLUBLE FIBROIN

CAS Number
Not publicly assigned (silk-derived protein; sometimes grouped under fibroin CAS 9007-76-5)
Function
Skin Conditioning, Hair Conditioning, Film Forming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; CIR assessed Hydrolyzed Silk (fibroin-based) as safe in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Must confirm sericin removal (sericin is the allergenic silk protein); limited standalone data โ€” relies on read-across from Hydrolyzed Silk assessment; insect-origin disclosure may be needed for vegan claims

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Soluble Fibroin safe in cosmetics?

Must confirm sericin removal (sericin is the allergenic silk protein); limited standalone data โ€” relies on read-across from Hydrolyzed Silk assessment; insect-origin disclosure may be needed for vegan claims The EU classifies Soluble Fibroin as "permitted". Safety rating: GOOD.

Is Soluble Fibroin allowed in the EU?

Soluble Fibroin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Soluble Fibroin do in cosmetics?

Soluble Fibroin functions as: Skin Conditioning, Hair Conditioning, Film Forming. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (silk-derived protein; sometimes grouped under fibroin CAS 9007-76-5).

What is the Margin of Safety for Soluble Fibroin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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