NOAEL Studies Cosmetic Ingredient

SORBITAN PALMITATE NOAEL Studies

CAS: 26266-57-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =2600 mg/kg bw/day Mouse oral: feed 560 days chronic/long term toxicity EFSA ANS - 2017 - OutputID 2957 - body weight - systemic - Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives - doi:10.2903/j.efsa.2017.4788
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =10 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2017 - OutputID 2957 - Consumers - Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives - doi:10.2903/j.efsa.2017.4788
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =10 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2017 - OutputID 2957 - Consumers - Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives - doi:10.2903/j.efsa.2017.4788
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >15900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4741; row=10491; data_type=In Vivo; mixture=Chemical; chemical_name=Sorbitan monohexadecanoate; preferred_name=Sorbitan monohexadecanoate; dtxsid=DTXSID6029335; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029335; source_file=acute_oral.xlsx
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =2600 mg/kg bw/day Mouse oral chronic; 80 weeks chronic LONG_REF=EFSA ANS (2017). Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives. doi:10.2903/j.efsa.2017.4788.; TITLE=Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2017.4788; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15625122:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18b0d6994a2d7ffac8ce990c1d75c02a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 77K6Z421KU UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H42O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"77K6Z421KU"}
openFDA substances FDA UNII substance identifier 77K6Z421KU UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H42O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"77K6Z421KU"}
openFDA substances FDA UNII substance identifier 77K6Z421KU UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H42O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"77K6Z421KU"}
openFDA substances FDA UNII substance identifier 77K6Z421KU UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H42O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"77K6Z421KU"}