Is Sorbitan Trioleate safe in cosmetics?
Sorbitan Trioleate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Sorbitan Trioleate
Also known as: Sorbitan, tri-(9Z)-9-octadecenoate, EINECS 247-569-3, Liposorb TO, Protachem STO, Rheodol SP 030 (+4 more)
INCI: SORBITAN TRIOLEATE
Sorbitan Trioleate (CAS 26266-58-0) is a cosmetic cosmetic ingredient functioning as Surfactant – Emulsifying Agent; HLB 1.8. Reported NOAEL =50 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 26266-58-0 →
Function
Surfactant – Emulsifying Agent; HLB 1.8
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
[(2R)-2-[(2R,3R,4S)-4-hydroxy-3-[(Z)-octadec-9-enoyl]oxyoxolan-2-yl]-2-[(Z)-octadec-9-enoyl]oxyethyl] (Z)-octadec-9-enoate
InChIKey
PRXRUNOAOLTIEF-ADSICKODSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted; CIR safe as used (1985, reaffirmed 2014). Also FDA inactive drug ingredient and diluent in color additives (21CFR73.1001)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sorbitan Trioleate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Sorbitan Trioleate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | injection | Rat | subchronic | ECHA |
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LC50 | >5270 mg/m3 | Rat | inhalation | - | ECHA |
| LD50 | >39800 mg/kg | Rat | oral | - | ECHA |
| LD50 | >39800 mg/kg | Rat | oral | - | ECHA |
| LD50 | =875 mg/kg | Rat | injection | - | ECHA |
| LD50 | =960 mg/kg | Rat | injection | - | ECHA |
| LD50 | =1020 mg/kg | Rat | injection | - | ECHA |
| LD50 | =1050 mg/kg | Rat | injection | - | ECHA |
| LD50 | =943 mg/kg | Rat | injection | - | ECHA |
| LD50 | =975 mg/kg | Rat | injection | - | ECHA |
| NOAEL | =50 mg/kg-day | Rat | injection | subchronic | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dispersing agent
Emulsifier
Fragrance
Lubricating agent
Surfactant (surface active agent)
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for Sorbitan Trioleate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sorbitan Trioleate by CAS number or substance name.
Studies
1
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
50 mg/kg bw/day
ECHA
Known Synonyms
Sorbitan, tri-(9Z)-9-octadecenoate
EINECS 247-569-3
Liposorb TO
Protachem STO
Rheodol SP 030
Sorbitani trioleas
Trioleate de sorbitan
Trioleato de sorbitano
UNII-QE6F49RPJ1
Chemical Function
Emulsifier
Surfactant (surface active agent)
Fragrance
Lubricating agent
Dispersing agent
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Indirect additives food contact (10/2018)
active_ingredient; animal_products; Europe; pharmaceutical; residue
SCIL (9/2019)
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SORBITAN TRIOLEATE
ChEMBL ID
CHEMBL3989778
Max Phase
2
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sorbitan trioleate
E Number
E496
ADI
25 mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is Sorbitan Trioleate allowed in the EU?
Sorbitan Trioleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sorbitan Trioleate do in cosmetics?
Sorbitan Trioleate functions as: Surfactant – Emulsifying Agent; HLB 1.8. It is classified as a cosmetic ingredient in our database. CAS number: 26266-58-0.
What is the NOAEL for Sorbitan Trioleate?
The NOAEL (No Observed Adverse Effect Level) for Sorbitan Trioleate is =50 mg/kg bw/day based on a subchronic study via injection route in Rat. Source: ECHA.
Is Sorbitan Trioleate used outside cosmetics?
Sorbitan Trioleate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sorbitan Trioleate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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