Good Cosmetic Ingredient NOAEL Data

Steareth-50

INCI: STEARETH-50

CAS Number
68439-49-6
Function
Surfactant – cleansing agent; solubilizing agent; nonionic surfactant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR-reviewed — safe when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Steareth-50. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 800 mg/kg bw/day oral rat oral REACH
NOAEL 800 mg/kg bw/day oral rat oral REACH

Expert Verdict

1,4-Dioxane risk (potentially higher due to 50 EO); prepared from cetyl/stearyl alcohol blend

⚠️
Concern Level: Low

Regulatory Flags

eu_children_restricted epa_safer_alternative

Frequently Asked Questions

Is Steareth-50 safe in cosmetics?

1,4-Dioxane risk (potentially higher due to 50 EO); prepared from cetyl/stearyl alcohol blend The EU classifies Steareth-50 as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Steareth-50 allowed in the EU?

Steareth-50 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Steareth-50 do in cosmetics?

Steareth-50 functions as: Surfactant – cleansing agent; solubilizing agent; nonionic surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 68439-49-6.

What is the Margin of Safety for Steareth-50?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Steareth-50?

The NOAEL (No Observed Adverse Effect Level) for Steareth-50 is 800 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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