| ECHA |
LOAEL |
=46.9 |
mg/kg bw/day |
Mouse |
oral |
subchronic; 13 weeks |
subchronic |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf90e4b0a7c65d1ce858; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/6/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850069:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4eed4865929af16c387acbb91865b8f7 |
| ECHA |
LOAEL |
=187.5 |
mg/kg bw/day |
Mouse |
oral |
subchronic; 13 weeks |
subchronic |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf90e4b0a7c65d1ce858; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/6/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850070:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d98038f764bc7382c0f925b3f2a6e95 |
| ECHA |
LOAEL |
=375 |
mg/kg bw/day |
Rat |
oral |
chronic; 2 years |
chronic |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce851; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/6/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850067:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_18c06571fccd0a982afb00ed7ff74673 |
| ECHA |
LOAEL |
=508 |
mg/kg bw/day |
Rat |
oral |
- |
reproduction developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d091; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/9/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15857666:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bea6d5668546e1f2b631dc0bea602e0e |
| ECHA |
LOAEL |
=750 |
mg/kg bw/day |
Rat |
oral |
chronic; 2 years |
chronic |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce851; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/6/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834735_15850068:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efa6ede0db370ba0bd94908558b98933 |
| ECHA |
LOAEL |
=1400 |
mg/kg bw/day |
Rat |
dermal |
- |
reproduction developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d076; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/9/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856300_15857471_15857580_15857728:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_715cfbb7d2b4cc77a8aa682693dbd6e5 |
| ECHA |
NOAEL |
=43 |
mg/kg bw/day |
Rat |
dermal |
- |
reproduction developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d09c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/9/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: organ weights and organ / body weight ratios|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856300_15857471_15857580_15857728:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06a31bd8e0d9a4f3ba7c58b29ef6dda5 |
| ECHA |
NOAEL |
=70 |
mg/kg bw/day |
Rat |
dermal |
- |
reproduction developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d063; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/9/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: dermal irritation|P0: body weight and weight gain|P0: food consumption and compound intake|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856300_15857471_15857580_15857728:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9eb74c3596bc88bb09ab7a26fd1a0b36 |
| ECHA |
NOAEL |
=93 |
mg/kg bw/day |
Rat |
oral |
subchronic; 13 weeks |
subchronic |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf90e4b0a7c65d1ce85c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/6/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836139_15850071:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aee162c207c6065a93bbe52daab1cd73 |
| ECHA |
NOAEL |
=140 |
mg/kg bw/day |
Rat |
dermal |
- |
reproduction developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d076; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/9/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15855486:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba69824828c53a47638617e88b03b5f2 |
| ECHA |
NOAEL |
=430 |
mg/kg bw/day |
Rat |
dermal |
- |
reproduction developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d088; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/9/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856300_15857471_15857580_15857728:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_751015c349af67ccc4f05f90e2122ddb |
| ECHA |
NOAEL |
=500 |
mg/kg bw/day |
Mouse |
oral |
short-term; 16 days |
short-term |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d2297a5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/6/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850072:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fede263bc6893aca246d839f2a716c08 |
| ECHA |
NOAEL |
=1000 |
mg/kg bw/day |
Rat |
oral |
short-term; 16 days |
short-term |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d2297ac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/31233/7/6/2?documentUUID=2d0c8ff2-90f1-4764-b56f-dd13dfe3ec42; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850073:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_919b65135278fb86bb03fb9b22c43823 |