NOAEL Studies Cosmetic Ingredient

Styrene Oxide NOAEL Studies

INCI: STYRENE OXIDE (NOT AN ESTABLISHED INCI INGREDIENT)

CAS: 96-09-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 NSRL SQE4 ug/day - - 1988-10-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL SQE4 ug/day - - 1988-10-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL SQE4 ug/day - - 1988-10-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL SQE4 ug/day - - 1988-10-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-10-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-10-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-10-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-10-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"4","source_table":"prop65_listings"}
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 2A IARC group - - 2018 IARC Monographs {"additional_info":"NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data; volume_publication_year=2019","evaluation_year":2018,"source_table":"iarc_classifications","volume":"Sup 7, 60, 121"}
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11781; row=3921; data_type=In Vivo; mixture=Chemical; chemical_name=Styrene oxide; preferred_name=Styrene oxide; dtxsid=DTXSID2021286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021286; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021286; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11783; row=3922; data_type=In Vivo; mixture=Chemical; chemical_name=Styrene oxide; preferred_name=Styrene oxide; dtxsid=DTXSID2021286; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021286; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021286; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4290 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_11785; row=3923; data_type=In Vivo; mixture=Chemical; chemical_name=Styrene oxide; preferred_name=Styrene oxide; dtxsid=DTXSID2021286; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021286; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021286; source_file=acute_oral.xlsx
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 2 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=2650; Record_ID=cancer_5173; Data_Type=WOE; Formulation_Name=Styrene oxide; Mixture=Chemical; DTXSID=DTXSID2021286; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2A; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/78; http://publications.iarc.fr/582; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021286; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021286
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14924; RecordID=ARPathway2016_1775; DatasetName=ARPathway2016; DTXSID=DTXSID2021286; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021286; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021286
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOEL =180 mg/kg bw/day Rat oral chronic; 24 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce552; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/6/2?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832683_15850033:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b5bbe6fa9115fd5fe8259dbdbe9e8ac
ToxValDB_ECHA_IUCLID LOEL =60 mg/kg bw/day Mouse oral chronic; 20 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce558; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/6/2?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839060_15850035:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6958d16632c95b27e0645b41f18280e
ToxValDB_ECHA_IUCLID LOEL =77 mg/kg bw/day Rat oral chronic; 24 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce552; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/6/2?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832683_15850033:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ec8bab027ad85e1404bacd2123af6aa0
ToxValDB_ECHA_IUCLID LOEL =26 mg/kg bw/day Mouse oral chronic; 20 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce558; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/6/2?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839060_15850035:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_65e750ee800ef02da0bf75ef8afb2eb7
ToxValDB_ECHA_IUCLID NOAEL >=375 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa2fe4b0a7c65d1b4b74; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/8?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15820263:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0c5abba1e33cec5dd10eef38c6f1d0ec
ToxValDB_ECHA_IUCLID NOAEL >=50 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa2fe4b0a7c65d1b4b76; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/8?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15820264:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e30eeb690e00e20ac67e7aaadb0821e
ToxValDB_ECHA_IUCLID NOAEL =128 mg/kg bw/day Mouse oral chronic; 20 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce558; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/6/2?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839059_15850034:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_544b2108482b293489c2fcc838f2885d
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Mouse oral chronic; 20 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce558; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20603/7/6/2?documentUUID=205bd9bb-fe30-4dde-a89b-1f5b5255af73; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839059_15850034:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bfbcd95033fef3e76b7417ca9fd18a13
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9QH06NGT6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9QH06NGT6O"}
openFDA substances FDA UNII substance identifier 9QH06NGT6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9QH06NGT6O"}
openFDA substances FDA UNII substance identifier 9QH06NGT6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9QH06NGT6O"}
openFDA substances FDA UNII substance identifier 9QH06NGT6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9QH06NGT6O"}