NOAEL Studies Cosmetic Ingredient

Subtilisin NOAEL Studies

INCI: SUBTILISIN

CAS: 9014-01-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 572 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=df9817ca-9210-4a80-9cd4-2818415044b7.i6z; document=3be09340-4eea-4634-9bcc-ba6678e8cbbc_df9817ca-9210-4a80-9cd4-2818415044b7.i6d; document_key=3be09340-4eea-4634-9bcc-ba6678e8cbbc/df9817ca-9210-4a80-9cd4-2818415044b7; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2019-08-29; basis=other:; key_result=true; entry_uuid=5cee6f62-31ee-4a23-90bd-4185d3493cb3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 572 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=df9817ca-9210-4a80-9cd4-2818415044b7.i6z; document=3be09340-4eea-4634-9bcc-ba6678e8cbbc_df9817ca-9210-4a80-9cd4-2818415044b7.i6d; document_key=3be09340-4eea-4634-9bcc-ba6678e8cbbc/df9817ca-9210-4a80-9cd4-2818415044b7; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2019-08-29; basis=other:; key_result=true; entry_uuid=5cee6f62-31ee-4a23-90bd-4185d3493cb3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 572 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=df9817ca-9210-4a80-9cd4-2818415044b7.i6z; document=3be09340-4eea-4634-9bcc-ba6678e8cbbc_df9817ca-9210-4a80-9cd4-2818415044b7.i6d; document_key=3be09340-4eea-4634-9bcc-ba6678e8cbbc/df9817ca-9210-4a80-9cd4-2818415044b7; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2019-08-29; basis=other:; key_result=true; entry_uuid=5cee6f62-31ee-4a23-90bd-4185d3493cb3
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >1.4 mg/kg bw/day Rabbit dermal acute; 4 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ed5e4b096bca877b4a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14104/7/6/4?documentUUID=df9817ca-9210-4a80-9cd4-2818415044b7; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15826660:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cab7bb3bfbfee9f2ddfbdbd953a9980b
ToxValDB_ECHA_IUCLID NOAEL =572 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf51e4b0a7c65d1cd784; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14104/7/6/2?documentUUID=df9817ca-9210-4a80-9cd4-2818415044b7; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15833670:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a74132689470aed56c62e92a2b4853c
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0ZP13EBC5Y UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"0ZP13EBC5Y"}
openFDA substances FDA UNII substance identifier 0ZP13EBC5Y UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"0ZP13EBC5Y"}
openFDA substances FDA UNII substance identifier 0ZP13EBC5Y UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"0ZP13EBC5Y"}
openFDA substances FDA UNII substance identifier 0ZP13EBC5Y UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"0ZP13EBC5Y"}