Sulforaphane

INCI: SULFORAPHANE (TYPICALLY DELIVERED AS BRASSICA OLERACEA ITALICA EXTRACT IN COSMETICS)

CAS Number
4478-93-7 (racemic) / 142825-10-3 (L-form)
Function
Antioxidant, Skin conditioning, Anti-inflammatory
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; also has GRAS status in food context

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Highly bioactive isothiocyanate โ€” potent Nrf2 pathway activator; at high concentrations may cause cellular stress; stability is poor (degrades with heat, light, pH extremes); typically standardized within broccoli seed extract rather than used as isolate; limited cosmetic-specific safety dossier โ€” most data is nutraceutical/pharma

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Concern Level: Low

Frequently Asked Questions

Is Sulforaphane safe in cosmetics?

Highly bioactive isothiocyanate โ€” potent Nrf2 pathway activator; at high concentrations may cause cellular stress; stability is poor (degrades with heat, light, pH extremes); typically standardized within broccoli seed extract rather than used as isolate; limited cosmetic-specific safety dossier โ€” most data is nutraceutical/pharma The EU classifies Sulforaphane as "permitted". Safety rating: GOOD.

Is Sulforaphane allowed in the EU?

Sulforaphane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sulforaphane do in cosmetics?

Sulforaphane functions as: Antioxidant, Skin conditioning, Anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 4478-93-7 (racemic) / 142825-10-3 (L-form).

What is the Margin of Safety for Sulforaphane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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