t-Butyl Dimethyl Silyl Grape Seed Extract

INCI: T-BUTYL DIMETHYL SILYL GRAPE SEED EXTRACT (REGISTERED IN COSING AS A MODIFIED BOTANICAL)

CAS Number
Not assigned (silylated botanical derivative — no standard CAS)
Function
Skin Conditioning — silylated grape seed polyphenols for enhanced lipophilicity and skin delivery
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No CIR monograph; falls under general cosmetic ingredient provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Chemically modified botanical — the silyl protecting group alters bioavailability; ensure hydrolysis products are characterized; limited published toxicological data on this specific derivative; treat as novel ingredient for safety assessment purposes

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is t-Butyl Dimethyl Silyl Grape Seed Extract safe in cosmetics?

Chemically modified botanical — the silyl protecting group alters bioavailability; ensure hydrolysis products are characterized; limited published toxicological data on this specific derivative; treat as novel ingredient for safety assessment purposes The EU classifies t-Butyl Dimethyl Silyl Grape Seed Extract as "permitted". Safety rating: MODERATE.

Is t-Butyl Dimethyl Silyl Grape Seed Extract allowed in the EU?

t-Butyl Dimethyl Silyl Grape Seed Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does t-Butyl Dimethyl Silyl Grape Seed Extract do in cosmetics?

t-Butyl Dimethyl Silyl Grape Seed Extract functions as: Skin Conditioning — silylated grape seed polyphenols for enhanced lipophilicity and skin delivery. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (silylated botanical derivative — no standard CAS).

What is the Margin of Safety for t-Butyl Dimethyl Silyl Grape Seed Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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