NOAEL Studies
Cosmetic Ingredient
Tartaric Acid NOAEL Studies
INCI: TARTARIC ACID
CAS: 87-69-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 990 | mg/kg bw/day | dog | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1200 | mg/kg bw/day | rat | oral | 730 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 274 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 181 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 225 | mg/kg bw/day | hamster | oral | 5 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 215 | mg/kg bw/day | rabbit | oral | 15 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =3100 | mg/kg bw/day | Rat | oral: feed | 728 days | chronic/long term toxicity | EFSA FAF - 2020 - OutputID 3504 - no adverse effect observed at single/highest dose - Re-evaluation of L(+)-tartaric acid (E 334), sodium tartrates (E 335), potassium tartrates (E 336), potassium sodium tartrate (E 337) and calcium tartrate (E 354) as food additives - doi:10.2903/j.efsa.2020.6030 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =3100 | mg/kg bw/day | Rat | oral: feed | 728 days | chronic/long term toxicity | EFSA FAF - 2020 - OutputID 3504 - no adverse effect observed at single/highest dose - Re-evaluation of L(+)-tartaric acid (E 334), sodium tartrates (E 335), potassium tartrates (E 336), potassium sodium tartrate (E 337) and calcium tartrate (E 354) as food additives - doi:10.2903/j.efsa.2020.6030 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | <=30 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA AFC - 2003 - OutputID 365 - Consumers - Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to L-Carnitine-L-tartrate for use in foods for particular nutritional purposes. - doi:10.2903/j.efsa.2003.19 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =240 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA FAF - 2020 - OutputID 3504 - Consumers - Re-evaluation of L(+)-tartaric acid (E 334), sodium tartrates (E 335), potassium tartrates (E 336), potassium sodium tartrate (E 337) and calcium tartrate (E 354) as food additives - doi:10.2903/j.efsa.2020.6030 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | <=30 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA AFC - 2003 - OutputID 365 - Consumers - Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to L-Carnitine-L-tartrate for use in foods for particular nutritional purposes. - doi:10.2903/j.efsa.2003.19 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =240 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA FAF - 2020 - OutputID 3504 - Consumers - Re-evaluation of L(+)-tartaric acid (E 334), sodium tartrates (E 335), potassium tartrates (E 336), potassium sodium tartrate (E 337) and calcium tartrate (E 354) as food additives - doi:10.2903/j.efsa.2020.6030 |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | <5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_11061; row=13520; data_type=In Vivo; mixture=Chemical; chemical_name=L-Tartaric acid; preferred_name=L-Tartaric acid; dtxsid=DTXSID8023632; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_11059; row=13521; data_type=In Vivo; mixture=Chemical; chemical_name=L-Tartaric acid; preferred_name=L-Tartaric acid; dtxsid=DTXSID8023632; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11092; RecordID=ARPathway2016_1668; DatasetName=ARPathway2016; DTXSID=DTXSID8023632; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
NTP_ICE_skin_sensitization 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | >1050.602 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8142; Record_ID=skin_sensitization_invitro_2165; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=150.086; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1050.602; Converted_Response_Unit=ug/mL; Response=1050.602; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | CV75 | 416.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3367; Record_ID=skin_sensitization_invitro_768; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=h-CLAT; Endpoint=CV75; Reported_Response=416.7; Reported_Response_Unit=ug/mL; Response=416.7; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Depletion Cys | 6.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1152; Record_ID=skin_sensitization_invitro_312; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=6.6; Reported_Response_Unit=%; Response=6.6; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Depletion Cys | 3.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1157; Record_ID=skin_sensitization_invitro_313; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.8; Reported_Response_Unit=%; Response=3.8; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Depletion Lys | -2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1151; Record_ID=skin_sensitization_invitro_312; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-2; Reported_Response_Unit=%; Response=-2; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Depletion Lys | 1.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1156; Record_ID=skin_sensitization_invitro_313; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.2; Reported_Response_Unit=%; Response=1.2; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 2.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1154; Record_ID=skin_sensitization_invitro_312; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=2.2999999999999998; Reported_Response_Unit=%; Response=2.3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 2.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1159; Record_ID=skin_sensitization_invitro_313; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=2.5; Reported_Response_Unit=%; Response=2.5; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | EC1.5 | 3 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6833; Record_ID=skin_sensitization_invitro_1617; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3; Reported_Response_Unit=uM; Response=3; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6835; Record_ID=skin_sensitization_invitro_1619; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response=No induction; Reported_Response_Unit=Unitless; Conversion_Factor=Text to numeric; Conversion_Factor_Value=No induction assumed >2000 uM; Conversion_Factor_Source=Manually calculated; Converted_Response_Modifier=>; Converted_Response=2000; Converted_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | IC50 | 70.2 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6839; Record_ID=skin_sensitization_invitro_1617; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=70.2; Reported_Response_Unit=uM; Response=70.2; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | IC50 | >2400 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7624; Record_ID=skin_sensitization_invitro_1792; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Imax | 1.2 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6841; Record_ID=skin_sensitization_invitro_1619; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2; Reported_Response_Unit=Unitless; Response=1.2; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Imax | 15.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6843; Record_ID=skin_sensitization_invitro_1617; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=15.3; Reported_Response_Unit=Unitless; Response=15.3; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
| NTP_ICE_skin_sensitization | Imax | 1.277 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7518; Record_ID=skin_sensitization_invitro_1792; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8023632; Assay=LuSens; Endpoint=Imax; Reported_Response=1.277244433; Reported_Response_Unit=Unitless; Response=1.277; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023632 |
ToxValDB_ECHA_IUCLID 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | ~3606 | mg/kg bw/day | Mouse | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/28340/7/3/2?documentUUID=7485cb6b-b7bd-4e81-9edc-c495a511a97c; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15801256:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b74586d2e1eef07c24e8e47694a67aa2 |
| ToxValDB_ECHA_IUCLID | LEL | ~5000 | mg/kg bw/day | Rabbit | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/28340/7/3/2?documentUUID=7485cb6b-b7bd-4e81-9edc-c495a511a97c; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15802471:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b4429eeddacc76e502e88f6b60d7cb28 |
| ToxValDB_ECHA_IUCLID | LEL | ~10000 | mg/kg bw/day | Cat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/28340/7/3/2?documentUUID=7485cb6b-b7bd-4e81-9edc-c495a511a97c; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15805047:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4f8a31ce2a47c95bbaf749fb95121f2c |
| ToxValDB_ECHA_IUCLID | LEL | =310 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/28340/7/3/2?documentUUID=7485cb6b-b7bd-4e81-9edc-c495a511a97c; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807538_15807539:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_34324c30ce224c24f16232310c8ca574 |
| ToxValDB_ECHA_IUCLID | LEL | =2800 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/28340/7/3/2?documentUUID=7485cb6b-b7bd-4e81-9edc-c495a511a97c; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807538_15807539:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d052d1850c736e607d74131668161985 |
| ToxValDB_ECHA_IUCLID | LEL | ~181 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd65c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15459/7/9/3?documentUUID=b3ac8264-7183-4be5-83f6-2f4fdffd1795; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=maternal: behaviour (functional findings)|maternal: body weight and weight gain|maternal: dead fetuses|maternal: food consumption and compound intake|maternal: pre and post implantation loss|maternal: total litter losses by resorption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|food and/or water consumption|neurobehavior|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824739_15824740_15824741_15824742:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b5ad4f0ebb446b68a8209c3e93ee093 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~225 | mg/kg bw/day | Hamster | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232373; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/28340/7/9/3?documentUUID=7485cb6b-b7bd-4e81-9edc-c495a511a97c; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15821167:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54b1bbf515a4e58d859aa4ae76f0f5a4 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~274 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd66e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15459/7/9/3?documentUUID=b3ac8264-7183-4be5-83f6-2f4fdffd1795; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824743_15824744_15824745_15824746:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f93aae696bfb70a6b46ec0259492d2b |
| ToxValDB_ECHA_IUCLID | NOAEL | ~3000 | mg/kg bw/day | Mouse | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d95; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25733/7/10/2?documentUUID=e996d280-6f46-4e2b-a957-c92d1aeb081b; YEAR=1925; ORIGINAL_YEAR=1925; STUDY_GROUP=ECHA IUCLID_dup_Immunotoxicity_15825527_15825528_15825529_15825530:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6d89e15f23a6da1c1c1e3506ace2db95 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =96 | mg/L | Mouse | oral | short-term; 30.44 days | short-term | LONG_REF=Res. Commun. Chem. Pathol. Pharmacol.79(3): 377-380 Domingo,J.L., M. Gomez, D.J. Sanchez, J.M. Llobet, and J. Corbella Effect of Various Dietary Constituents on Gastrointestinal Absorption of Aluminum from Drinking Water and Diet 1993; TITLE=Effect of Various Dietary Constituents on Gastrointestinal Absorption of Aluminum from Drinking Water and Diet; AUTHOR=Domingo,J.L., M. Gomez, D.J. Sanchez, J.M. Llobet, and J. Corbella; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151648; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Aluminum content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594668_15603251:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5d4913aa8966dc9c4f82496a5bb1f8dd |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =3100 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=EFSA FAF (2020). Re-evaluation of L(+)-tartaric acid (E 334), sodium tartrates (E 335), potassium tartrates (E 336), potassium sodium tartrate (E 337) and calcium tartrate (E 354) as food additives. doi:10.2903/j.efsa.2020.6030.; TITLE=Re-evaluation of L(+)-tartaric acid (E 334), sodium tartrates (E 335), potassium tartrates (E 336), potassium sodium tartrate (E 337) and calcium tartrate (E 354) as food additives; AUTHOR=EFSA FAF; DOI=doi:10.2903/j.efsa.2020.6030; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614278:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9b5acaebbc26fb99251576dfee889309 |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=30 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650aff20e4b0d99f5a8819e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/4746; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=WHO JECFA ADI:15715603:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efbbce439953d7e1d29ce4d1166c316f |
openFDA substances 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |
| openFDA substances | FDA UNII substance identifier | W4888I119H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H6O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W4888I119H"} |