Regulatory Status
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Safety Data
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Expert Verdict
α,β-unsaturated carbonyl (Michael acceptor) — structural alert for skin sensitization and protein reactivity; chalcone core requires DPRA/KeratinoSens™ testing to confirm sensitization potential; limited toxicological dossier; ensure batch-specific purity to avoid free hydroxychalcone impurities
Regulatory Flags
Frequently Asked Questions
Is Tetraacetoxychalcone safe in cosmetics?
α,β-unsaturated carbonyl (Michael acceptor) — structural alert for skin sensitization and protein reactivity; chalcone core requires DPRA/KeratinoSens™ testing to confirm sensitization potential; limited toxicological dossier; ensure batch-specific purity to avoid free hydroxychalcone impurities The EU classifies Tetraacetoxychalcone as "permitted". Safety rating: MODERATE.
Is Tetraacetoxychalcone allowed in the EU?
Tetraacetoxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetraacetoxychalcone do in cosmetics?
Tetraacetoxychalcone functions as: Skin conditioning / Antioxidant (chalcone-based bioactive). It is classified as a cosmetic ingredient in our database. CAS number: Not widely published (acetylated chalcone derivative).
What is the Margin of Safety for Tetraacetoxychalcone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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