Is TETRAHYDROCURCUMIN safe in cosmetics?
TETRAHYDROCURCUMIN has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
TETRAHYDROCURCUMIN
Also known as: Tetrahydrodiferuloylmethane, 3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione, 1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione, AS-KTC 004 (+5 more)
TETRAHYDROCURCUMIN (CAS 36062-04-1) is a cosmetic cosmetic ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 36062-04-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
InChIKey
LBTVHXHERHESKG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "brightening, antioxidant-protection", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "12-22", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Specialize…
skin_brightening
{"cas_number": "36062-04-1", "mechanism_of_action": "Tyrosinase inhibition; more stable than curcumin", "melanogenesis_pathway_target": "Tyrosinase", "tyrosinase_inhibition_ic50_um": "~80-150", "tyrosinase_inhibition_vs_kojic_acid": "~1-2x comparable", "melanosome_transfer_inhibitor": "No", "melanin_oxidation_reducer": "Yes", "endothelin_pathway_blocker": "No", "alpha_msh_antagonist": "No", "clini…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for TETRAHYDROCURCUMIN.
Regulatory Flags
cosing-sourced
eu-permitted
antioxidant
needs-enrichment
Known Synonyms
Tetrahydrodiferuloylmethane
3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione
1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
AS-KTC 004
HZIV 81-2
NSC 687845
Sabiwhite
UNII-00U0645U03
QA-0342
Chemical Function
Antioxidant
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of dermal cosmetic products at concentrations no more than 0.1%. This chemical is not to be used in topical products intended for the eye.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TETRAHYDROCURCUMIN
ChEMBL ID
CHEMBL318743
Frequently Asked Questions
Is TETRAHYDROCURCUMIN allowed in the EU?
TETRAHYDROCURCUMIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TETRAHYDROCURCUMIN do in cosmetics?
TETRAHYDROCURCUMIN functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 36062-04-1.
Is TETRAHYDROCURCUMIN used outside cosmetics?
TETRAHYDROCURCUMIN also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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TETRAHYDRODIFERULOYLMETHANE
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Antioxidant
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