Poor Cosmetic Ingredient NOAEL Data

Tetrahydrofurfuryl Methacrylate

INCI: TETRAHYDROFURFURYL METHACRYLATE

CAS Number
2455-24-5
Function
Film Forming – produces continuous film on nails; primary monomer in UV/LED gel polishes (≥50% concentration)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status restricted
US Notes Not specifically restricted; CIR assessed as safe in nail enhancement products when skin contact is avoided

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Tetrahydrofurfuryl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat oral REACH

Expert Verdict

H360: Reproductive toxicity Cat 1B; H315: Skin irritant; H319: Eye irritant; H335: Respiratory irritant; H412: Aquatic chronic toxicity; must avoid skin contact with uncured product

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Concern Level: High

Frequently Asked Questions

Is Tetrahydrofurfuryl Methacrylate safe in cosmetics?

H360: Reproductive toxicity Cat 1B; H315: Skin irritant; H319: Eye irritant; H335: Respiratory irritant; H412: Aquatic chronic toxicity; must avoid skin contact with uncured product The EU classifies Tetrahydrofurfuryl Methacrylate as "restricted". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is Tetrahydrofurfuryl Methacrylate allowed in the EU?

Tetrahydrofurfuryl Methacrylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrahydrofurfuryl Methacrylate do in cosmetics?

Tetrahydrofurfuryl Methacrylate functions as: Film Forming – produces continuous film on nails; primary monomer in UV/LED gel polishes (≥50% concentration). It is classified as a cosmetic ingredient in our database. CAS number: 2455-24-5.

What is the Margin of Safety for Tetrahydrofurfuryl Methacrylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Tetrahydrofurfuryl Methacrylate?

The NOAEL (No Observed Adverse Effect Level) for Tetrahydrofurfuryl Methacrylate is 300 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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