Regulatory Status
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Safety Data
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Expert Verdict
Pharmacological activity — documented sedative/analgesic effects via dopamine antagonism ; potential for systemic effects if dermal absorption is significant; hepatotoxicity reported at oral pharmacological doses; ensure cosmetic-level concentrations maintain adequate MoS
Frequently Asked Questions
Is Tetrahydropalmatine HCl safe in cosmetics?
Pharmacological activity — documented sedative/analgesic effects via dopamine antagonism ; potential for systemic effects if dermal absorption is significant; hepatotoxicity reported at oral pharmacological doses; ensure cosmetic-level concentrations maintain adequate MoS The EU classifies Tetrahydropalmatine HCl as "permitted". Safety rating: MODERATE.
Is Tetrahydropalmatine HCl allowed in the EU?
Tetrahydropalmatine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydropalmatine HCl do in cosmetics?
Tetrahydropalmatine HCl functions as: Antioxidant; Reducing agent. It is classified as a cosmetic ingredient in our database. CAS number: 5765-01-5 (HCl salt); free base: 2934-97-6.
What is the Margin of Safety for Tetrahydropalmatine HCl?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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