NOAEL Studies Cosmetic Ingredient

Tetramethyl Decynediol NOAEL Studies

INCI: TETRAMETHYL DECYNEDIOL

CAS: 126-86-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1790; RecordID=ARPathway2016_750; DatasetName=ARPathway2016; DTXSID=DTXSID7027041; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027041
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =15000 ppm Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a5e4b0a7c65d22f723; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/9/3?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820855_15821400:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd73a7530e7fffd4bb81141662eaadc6
ToxValDB_ECHA_IUCLID NOAEL =5000 ppm Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead27e4b0a7c65d1c2c23; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/6/2?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838426_15842852:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2af3b478e43117a3d0c27b8d90e4bf7e
ToxValDB_ECHA_IUCLID NOAEL =240 mg/kg bw/day Rat oral subchronic; 43 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead27e4b0a7c65d1c2c27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/6/2?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic|organ weights and organ / body weight ratios|serum/plasma biochemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15847300:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b86eba0c01b4c11e9d9a50b1fd884c96
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Dog oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead27e4b0a7c65d1c2c1d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/6/2?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID:15850626:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3d9faafadb52506c4f936d75c0c9a785
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral chronic; 91 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead27e4b0a7c65d1c2c29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/6/2?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; STUDY_GROUP=ECHA IUCLID:15850627:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_790668581d156f22163b95e71ba74ce5
ToxValDB_ECHA_IUCLID NOAEL =7500 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8afe4b0a7c65d2199fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/9/2?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855310_15856152:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_072853fa8d8df3736687bac32204407c
ToxValDB_ECHA_IUCLID NOAEL =2500 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8afe4b0a7c65d2199fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/9/2?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855310_15856152:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_27d94f47a544e355ef85dcf4346a115a
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b625d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/9/2?documentUUID=17a93151-096d-46e9-a51c-ec26185496de; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain|F1: haematology|F1: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15862619:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1a4ef4d679319aad438479d356cfaa68
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.76 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635167:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23a0bbbce7324518a02d34d901f12f60
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS LOAEL =200 mg/kg bw/day Dog oral chronic; 130 days chronic LONG_REF=APCI (EXT-94/090) / Pharmacopathics Research Laboratories; AUTHOR=APCI; QUALITY=2; EXTERNAL_SOURCE_ID=61574; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=HPVIS:15639767:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_be8617cd4911c3300ccc63f224cdc5b3
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier B9Y126NY8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9Y126NY8K"}
openFDA substances FDA UNII substance identifier B9Y126NY8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9Y126NY8K"}
openFDA substances FDA UNII substance identifier B9Y126NY8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9Y126NY8K"}
openFDA substances FDA UNII substance identifier B9Y126NY8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9Y126NY8K"}