Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Tetrasodium Etidronate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 41 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 78 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1620 other | oral | dog | oral | REACH |
| NOEL | >300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.260 other | oral | rat | oral | REACH |
Expert Verdict
Phosphonate — environmental persistence concerns; strictly regulated under EU Annex III; ensure compliance with concentration limits per product type
Regulatory Flags
Frequently Asked Questions
Is Tetrasodium Etidronate safe in cosmetics?
Phosphonate — environmental persistence concerns; strictly regulated under EU Annex III; ensure compliance with concentration limits per product type The EU classifies Tetrasodium Etidronate as "restricted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Tetrasodium Etidronate allowed in the EU?
Tetrasodium Etidronate EU regulatory status: restricted. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrasodium Etidronate do in cosmetics?
Tetrasodium Etidronate functions as: Chelating Agent, Emulsion Stabilising, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 3794-83-0.
What is the Margin of Safety for Tetrasodium Etidronate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrasodium Etidronate?
The NOAEL (No Observed Adverse Effect Level) for Tetrasodium Etidronate is 41 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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