Is Tetrasodium Etidronate safe in cosmetics?
Tetrasodium Etidronate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Tetrasodium Etidronate
Also known as: EINECS 223-267-7, Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt, (1-Hydroxyethylidene)diphosphonic acid, tetrasodium salt, UNII-CZZ9T1T1X4
INCI: TETRASODIUM ETIDRONATE
Tetrasodium Etidronate (CAS 3794-83-0) is a cosmetic cosmetic ingredient functioning as Chelating Agent, Emulsion Stabilising, Viscosity Controlling. NOAEL 41 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 1.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 3794-83-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetrasodium Etidronate is classified GHS Danger (H302, H319, H318, H413) in the chemicals database but is restricted in EU cosmetics at max 1.5%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating Agent, Emulsion Stabilising, Viscosity Controlling
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
tetrasodium;1,1-diphosphonatoethanol
InChIKey
KWXLCDNSEHTOCB-UHFFFAOYSA-J
Regulatory Status
EU EU Status
restricted
EU Max Conc.
1.5%
US US Status
permitted
US Notes
Permitted; CIR assessed — safe in present practices of use and concentration
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrasodium Etidronate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tetrasodium Etidronate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Emulsifier
Viscosity modifier
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Tetrasodium Etidronate.
Regulatory Flags
eu_children_restricted
Known Synonyms
EINECS 223-267-7
Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt
(1-Hydroxyethylidene)diphosphonic acid, tetrasodium salt
UNII-CZZ9T1T1X4
Chemical Function
Chelating agent
Viscosity modifier
Emulsifier
Regulatory Lists
children; Europe; Personal care
children; Europe; Personal care
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Tetrasodium Etidronate allowed in the EU?
Tetrasodium Etidronate EU regulatory status: restricted. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrasodium Etidronate do in cosmetics?
Tetrasodium Etidronate functions as: Chelating Agent, Emulsion Stabilising, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 3794-83-0.
Is Tetrasodium Etidronate used outside cosmetics?
Tetrasodium Etidronate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetrasodium Etidronate have different safety status in cosmetics vs industrial chemicals?
Tetrasodium Etidronate is classified GHS Danger (H302, H319, H318, H413) in the chemicals database but is restricted in EU cosmetics at max 1.5%.
Compliance Tools
Check Tetrasodium Etidronate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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