Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester)

INCI: TETRA(T-BUTOXYCARBONYL) ACETYL HEXAPEPTIDE-8 AMIDE BIS(METHYL ESTER)

CAS Number
Not publicly assigned (proprietary peptide derivative)
Function
Skin conditioning / Anti-wrinkle (Argireline® derivative — neuropeptide-based)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted as cosmetic ingredient; peptide cosmeceuticals not drug-classified unless therapeutic claims are made

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Prodrug design — confirm that t-butoxycarbonyl (Boc) deprotection products (isobutylene, CO₂) are non-toxic at use levels; verify peptide purity specifications; neuropeptide mechanism may attract regulatory scrutiny for drug-like claims

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Concern Level: Moderate

Frequently Asked Questions

Is Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester) safe in cosmetics?

Prodrug design — confirm that t-butoxycarbonyl (Boc) deprotection products (isobutylene, CO₂) are non-toxic at use levels; verify peptide purity specifications; neuropeptide mechanism may attract regulatory scrutiny for drug-like claims The EU classifies Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester) as "permitted". Safety rating: GOOD.

Is Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester) allowed in the EU?

Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester) do in cosmetics?

Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester) functions as: Skin conditioning / Anti-wrinkle (Argireline® derivative — neuropeptide-based). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (proprietary peptide derivative).

What is the Margin of Safety for Tetra(t-Butoxycarbonyl) Acetyl Hexapeptide-8 Amide Bis(Methyl Ester)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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