NOAEL Studies
Cosmetic Ingredient
Theobromine NOAEL Studies
INCI: THEOBROMINE
CAS: 83-67-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 41 | mg/kg bw/day | rabbit | oral | 6-29 Gestation day | Developmental | PAFA; FOOD CHEM TOXICOL 24:363-374 |
| COSMOS DB | LOAEL | 125 | mg/kg bw/day | rabbit | oral | 6-29 Gestation day | Developmental | PAFA; FOOD CHEM TOXICOL 24:363-374 |
| COSMOS DB | NOAEL | 21 | mg/kg bw/day | rabbit | oral | 24 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 53 | mg/kg bw/day | rat | oral | 14 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 75 | mg/kg bw/day | rabbit | oral | 24 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 88.2 | mg/kg bw/day | rabbit | oral | 120 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 110 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 144 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 199 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | rat | oral | 448 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 375 | mg/kg bw/day | mouse | oral | NA | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 8 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 501 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 518 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 600 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 638 | mg/kg bw/day | syrian hamster | oral | 35 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | <=349 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=true; upper_value=349; entry_uuid=6043dd88-35ab-43d7-9998-b070cafd0e88 |
| ECHA | LOAEL | 144 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=92507cd4-6c4f-4dd8-8c63-cd0615926889 |
| ECHA | LOAEL | 110 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=c0ba3a73-ac6f-4d63-a013-4e0355fe02f0 |
| ECHA | LOAEL | 200 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=3ff046df-f39d-4595-8cdb-8c692cd8e945 |
| ECHA | LOAEL | 531 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=1d4716ee-1205-4365-b39c-46d4cfe9d88f_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=1d4716ee-1205-4365-b39c-46d4cfe9d88f/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1984; basis=body weight and weight gain; key_result=true; entry_uuid=ba84a17d-cd2b-4859-bcf6-1e62ff81a26f |
| ECHA | NOAEL | <=126 | mg/kg bw/day | mouse | oral: feed | - | two-generation reproductive toxicity | dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=reproductive function (sperm measures); key_result=true; upper_value=126; entry_uuid=e7882d9e-7810-4e12-bb72-8d60932ba0ab |
| ECHA | NOAEL | <=630 | mg/kg bw/day | mouse | oral: feed | - | two-generation reproductive toxicity | dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=organ weights and organ / body weight ratios; key_result=true; upper_value=630; entry_uuid=2774a962-f725-468e-a45e-a43d7190a300 |
| ECHA | LOAEL | =200 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830503_15849922:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3927235c30aa1b9783e9ae2ef2ed77bd |
| ECHA | LOAEL | <=349 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15849921:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_986688f236ec3400e2722820296f53c0 |
| ECHA | LOAEL | =144 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830503_15849922:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d7b24b82d1e164d0eed0d02b62a6d373 |
| ECHA | LOAEL | =110 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID:15849923:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_caeda062f0f9386c7df37110e3df9eec |
| ECHA | NOAEL | <630 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba303; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/9/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856389_15863138:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d60811524469c95bcd3ac92def96f207 |
| ECHA | NOAEL | <=126 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba303; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/9/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=P0: reproductive function (sperm measures)|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856389_15863138:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4aa81b198c4c9804ce6f79e5c33882a0 |
EFSA 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =21 | mg/kg bw/day | Rabbit | - | - | reproduction toxicity | EFSA CONTAM - 2008 - OutputID 104 - development - teratogenic - Theobromine as undesirable substances in animal feed - doi:10.2903/j.efsa.2008.725 |
| EFSA | NOAEL | =7 | mg/kg bw/day | Pig | oral: feed | - | subchronic | EFSA CONTAM - 2008 - OutputID 104 - growth - systemic - Theobromine as undesirable substances in animal feed - doi:10.2903/j.efsa.2008.725 |
| EFSA | NOAEL | ca.35 | mg/kg bw/day | Sheep | oral: feed | 90 days | subchronic | EFSA CONTAM - 2008 - OutputID 104 - food consumption - systemic - Theobromine as undesirable substances in animal feed - doi:10.2903/j.efsa.2008.725 |
| EFSA | NOAEL | =21 | mg/kg bw/day | Rabbit | oral | - | developmental | LONG_REF=EFSA CONTAM (2008). Theobromine as undesirable substances in animal feed. doi:10.2903/j.efsa.2008.725.; TITLE=Theobromine as undesirable substances in animal feed; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2008.725; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EFSA:15613919:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e34e72b39e215a69014c108a178ca188 |
| EFSA | NOAEL | ~35 | mg/kg bw/day | Sheep | oral | subchronic; 3 months | subchronic | LONG_REF=EFSA CONTAM (2008). Theobromine as undesirable substances in animal feed. doi:10.2903/j.efsa.2008.725.; TITLE=Theobromine as undesirable substances in animal feed; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2008.725; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=EFSA:15613921:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c41244ac9b592b6970c3200fc2b1140 |
| EFSA | NOAEL | =7 | mg/kg bw/day | Pig | oral | - | subchronic | LONG_REF=EFSA CONTAM (2008). Theobromine as undesirable substances in animal feed. doi:10.2903/j.efsa.2008.725.; TITLE=Theobromine as undesirable substances in animal feed; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2008.725; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=growth; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15613922:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4797cc4a943dbf57ec91391210fcbdd |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | - |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =950 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10770; row=15669; data_type=In Vivo; mixture=Chemical; chemical_name=Theobromine; preferred_name=Theobromine; dtxsid=DTXSID9026132; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9026132; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1265 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_10771; row=15670; data_type=In Vivo; mixture=Chemical; chemical_name=Theobromine; preferred_name=Theobromine; dtxsid=DTXSID9026132; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9026132; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 396 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3668; Record_ID=adme_parameters_1092; Data_Type=Measured; DTXSID=DTXSID9026132; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=396.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132 |
| NTP ICE adme parameters | Fu | 0.955 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3667; Record_ID=adme_parameters_1092; Data_Type=Measured; DTXSID=DTXSID9026132; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.955; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=10245; Record_ID=cancer_4428; Data_Type=WOE; Formulation_Name=Theobromine; Mixture=Chemical; DTXSID=DTXSID9026132; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/69; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15384; RecordID=ARPathway2016_1633; DatasetName=ARPathway2016; DTXSID=DTXSID9026132; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | OBD445WZ5P | UNII | - | - | - | chemical | - |