NOAEL Studies
Cosmetic Ingredient
Theophylline NOAEL Studies
INCI: THEOPHYLLINE
CAS: 58-55-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 37.5 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=aaf8b72c-e56d-4687-9add-1fe3ee4e06ad_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=aaf8b72c-e56d-4687-9add-1fe3ee4e06ad/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=1bd57fe0-6493-411f-b4dd-cc5f8c8c9dab |
| ECHA | LOAEL | 126 | mg/kg bw/day | mouse | oral: feed | - | fertility, other | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=718f0512-5d89-4ef9-843f-7e85ae376598_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=718f0512-5d89-4ef9-843f-7e85ae376598/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=e651ef07-14a2-4752-ad56-bbd519d0baae |
| ECHA | LOAEL | 75 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=b2f271a6-9786-48fb-8ed1-8aa944a9468d_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=b2f271a6-9786-48fb-8ed1-8aa944a9468d/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=ce0f6e43-2967-420c-b1d8-95ccc31e95bd |
| ECHA | LOAEL | ca.7.5 | mg/kg bw/day | rat | oral: gavage | - | chronic toxicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=c0af6de8-329f-492c-aa8b-37bf05d95a6e_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=c0af6de8-329f-492c-aa8b-37bf05d95a6e/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=84d94fa5-951d-4fbf-8cc7-99caf9824f34 |
| ECHA | LOAEL | 225 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=f145abc4-0757-4053-b993-010c80a2fd93_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=f145abc4-0757-4053-b993-010c80a2fd93/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=e92133ad-98f3-4fbd-8f4a-1288c9864c19 |
| ECHA | LOAEL | 175 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=f145abc4-0757-4053-b993-010c80a2fd93_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=f145abc4-0757-4053-b993-010c80a2fd93/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=40804da9-d185-46af-a936-f45df31ec116 |
| ECHA | NOAEL | >=75 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=8a15b597-4921-42d4-99e6-80dfb4dc46ea_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=8a15b597-4921-42d4-99e6-80dfb4dc46ea/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=96b29646-fa08-4c0a-a730-b1dcaa586037 |
| ECHA | NOAEL | 124 | mg/kg bw/day | rat | oral: feed | - | developmental toxicity | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=1737e22b-d291-4721-b900-bf22435a2809_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=1737e22b-d291-4721-b900-bf22435a2809/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=f0408a8b-3fdc-40e1-b1ff-9dc0682a4261 |
| ECHA | NOAEL | >=259 | mg/kg bw/day | rat | oral: feed | - | developmental toxicity | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=1737e22b-d291-4721-b900-bf22435a2809_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=1737e22b-d291-4721-b900-bf22435a2809/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=90429bb9-82ed-456a-8828-37a501fb0e2c |
| ECHA | NOAEL | ca.282 | mg/kg bw/day | mouse | oral: drinking water | - | developmental toxicity | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=83b3a1ab-d4a7-4300-9e66-32286e84a164_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=83b3a1ab-d4a7-4300-9e66-32286e84a164/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=40eee7a0-775b-4db5-a2ab-2fcafe40e108 |
| ECHA | NOAEL | >=396 | mg/kg bw/day | mouse | oral: drinking water | - | developmental toxicity | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=83b3a1ab-d4a7-4300-9e66-32286e84a164_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=83b3a1ab-d4a7-4300-9e66-32286e84a164/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=a9730fb5-9a5d-49c5-bf65-21165f4f0db7 |
| ECHA | NOAEL | >=150 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=0beed73d-f9c6-4b61-b3de-938c45f52b7a_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=0beed73d-f9c6-4b61-b3de-938c45f52b7a/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=69e9d476-8dbc-4017-9d2a-1cc4d16a7b38 |
| ECHA | NOAEL | 30 | mg/kg bw/day | rabbit | intravenous | - | developmental toxicity | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=88dff1d5-2218-4148-a375-3e793cb60e71_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=88dff1d5-2218-4148-a375-3e793cb60e71/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=b95b941b-c0a1-4b56-8e95-8912c78cecdb |
| ECHA | NOAEL | ca.7.5 | mg/kg bw/day | mouse | oral: gavage | - | chronic toxicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=ff37903c-8116-41e1-8939-20dad1c0c8f7_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=ff37903c-8116-41e1-8939-20dad1c0c8f7/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=291a3b59-14f4-45cc-9e8b-c915602564f1 |
| ECHA | NOAEL | ca.50 | mg/kg bw/day | mouse | oral: gavage | - | chronic toxicity: oral | dossier=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6z; document=ff37903c-8116-41e1-8939-20dad1c0c8f7_8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec.i6d; document_key=ff37903c-8116-41e1-8939-20dad1c0c8f7/8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=f6d114b5-87bb-4699-ad6a-aac957838b33 |
| ECHA | LOAEL | =37.5 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb3b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11317/7/6/2?documentUUID=16df88a8-3ccd-430e-8676-9e9075cc008c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15849589_15849590:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_173ad3ef59cdd9bb08dc8ad8e5ad973a |
| ECHA | LOAEL | =75 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c954d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/6/2?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849591:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_99387954f55064445bc9fdd7ce647467 |
| ECHA | LOAEL | ~7.5 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c9559; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/6/2?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849592:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d5ec32b9bebf4961681c3a72c8225cc |
| ECHA | LOAEL | =175 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c9563; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/6/2?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849593:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cca5b9f82ddf52002bbf04064b87157a |
| ECHA | LOAEL | =225 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c9563; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/6/2?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849594:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e09d2222bdd649205fb672197de8fc76 |
| ECHA | LOAEL | =126 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab48e4b0a7c65d1b9a3a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11317/7/9/2?documentUUID=16df88a8-3ccd-430e-8676-9e9075cc008c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860637_15861767:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7c7d10b112c9f0b1befa4ffbfd396a22 |
| ECHA | NOAEL | >=75 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b4070; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/8?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15820472:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_90ae8937de897215d90d776f38fbf450 |
| ECHA | NOAEL | >=150 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b4070; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/8?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15820473:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dffa0fc5a216798f0be9279b07d648ea |
| ECHA | NOAEL | =30 | mg/kg bw/day | Rabbit | injection | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230b68; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/9/3?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15822645:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df574c73fa36f8c0743170165961536a |
| ECHA | NOAEL | =124 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be1a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/9/3?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15824956:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f1c51b00d2a7e42a23fd828584f3f76 |
| ECHA | NOAEL | ~282 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be1ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/9/3?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15824957:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_38b227afe8f5d58da49d28eae3b7b425 |
| ECHA | NOAEL | ~7.5 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c9577; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/6/2?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849595:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4768c2b1b7999ca95e497cb47c0da07c |
| ECHA | NOAEL | ~50 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c9577; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8037/7/6/2?documentUUID=8ccde7d4-8a7e-49b9-8cc9-57f9eb47ccec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849596:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4a67bc3440baebd420d15d661ada3d45 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | - |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0.7788 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1970; Record_ID=adme_parameters_456; Data_Type=Measured; DTXSID=DTXSID5021336; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.7788; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wood 2017; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021336; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021336 |
| NTP ICE adme parameters | Fu | 0.61 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1971; Record_ID=adme_parameters_456; Data_Type=Measured; DTXSID=DTXSID5021336; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.61; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Lombardo 2018; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021336; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021336 |
NTP ICE cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=5721; Record_ID=cancer_2468; Data_Type=WOE; Formulation_Name=Theophylline; Mixture=Chemical; DTXSID=DTXSID5021336; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/69; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021336; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021336 |
| NTP ICE cancer | Top dose | 75 | mg/kg | Rat | Gavage; Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=5714; Record_ID=cancer_2463; Data_Type=In Vivo; Formulation_Name=Theophylline; Mixture=Chemical; DTXSID=DTXSID5021336; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=75; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Dosed feed; Reference=TR-473; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr473/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021336; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021336 |
| NTP ICE cancer | Top dose | 150 | mg/kg | Mouse | Gavage; Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=5716; Record_ID=cancer_2464; Data_Type=In Vivo; Formulation_Name=Theophylline; Mixture=Chemical; DTXSID=DTXSID5021336; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=150; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Dosed feed; Reference=TR-473; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr473/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021336; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021336 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15392; RecordID=ARPathway2016_1361; DatasetName=ARPathway2016; DTXSID=DTXSID5021336; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021336; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021336 |
EPA ToxRefDB v3 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =75 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5171; toxval_study_source_id=studyid5171_Adult_F0_F_systemic; toxval_effect_list=hematology-neutrophils-neutrophils|organ weight-lung-relative to body weight|pathology microscopic-artery (general)-polyarteritis|organ weight-lung-absolute; dose_level=1; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Rat Feed); dsstox_substance_id=DTXSID5021336; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =125 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5171; toxval_study_source_id=studyid5171_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-artery (general)-polyarteritis|organ weight-kidney-absolute|hematology-platelet-platelet|organ weight-kidney-relative to body weight; dose_level=2; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Rat Feed); dsstox_substance_id=DTXSID5021336; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =225 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 week | SUB | study_id=5173; toxval_study_source_id=studyid5173_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|organ weight-thymus-absolute|pathology microscopic-liver-glycogen deposition|organ weight-thymus-relative to body weight|hematology-neutrophils-neutrophils|hematology-leukocyte (wbc) count differential-leukocyte (wbc); dose_level=1; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Mouse Feed); dsstox_substance_id=DTXSID5021336; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =175 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 week | SUB | study_id=5173; toxval_study_source_id=studyid5173_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|pathology microscopic-liver-glycogen deposition|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|hematology-neutrophils-neutrophils|hematology-lymphocyte-lymphocyte; dose_level=1; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Mouse Feed); dsstox_substance_id=DTXSID5021336; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =300 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 week | SUB | study_id=5174; toxval_study_source_id=studyid5174_Adult_F0_M_systemic; toxval_effect_list=hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-thymus-depletion lymphoid|in life observation-mortality-mortality|pathology microscopic-spleen-depletion lymphoid|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-lung-congestion; dose_level=3; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Mouse Gavage); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =7.5 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5175; toxval_study_source_id=studyid5175_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=1; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Chronic Rat); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =25 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5176; toxval_study_source_id=studyid5176_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-hyperactivity; dose_level=2; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Chronic Mouse); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =150 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5176; toxval_study_source_id=studyid5176_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-dilatation|pathology microscopic-thymus-necrosis|pathology microscopic-kidney-degeneration|pathology microscopic-spleen-depletion cellular|pathology microscopic-thyroid gland-degeneration|in life observation-body weight-body weight|in life observation-mortality-mortality; dose_level=3; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Chronic Mouse); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =150 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5172; toxval_study_source_id=studyid5172_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-artery (general)-polyarteritis; dose_level=3; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Rat Gavage); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5171; toxval_study_source_id=studyid5171_Adult_F0_F_systemic; toxval_effect_list=organ weight-lung-absolute|pathology microscopic-artery (general)-polyarteritis|organ weight-lung-relative to body weight|hematology-neutrophils-neutrophils; dose_level=0; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Rat Feed); dsstox_substance_id=DTXSID5021336; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =37.5 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 week | SUB | study_id=5172; toxval_study_source_id=studyid5172_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-artery (general)-polyarteritis|in life observation-mortality-mortality|in life observation-body weight-body weight gain|organ weight-thymus-relative to body weight|organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-thymus-absolute; dose_level=1; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Rat Gavage); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =150 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 week | SUB | study_id=5174; toxval_study_source_id=studyid5174_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-spleen-depletion lymphoid|in life observation-mortality-mortality|pathology microscopic-thymus-depletion lymphoid|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-lung-congestion|in life observation-body weight-body weight gain|in life observation-body weight-body weight|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch); dose_level=2; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Mouse Gavage); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =7.5 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5176; toxval_study_source_id=studyid5176_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-hyperactivity|in life observation-body weight-body weight; dose_level=1; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Chronic Mouse); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =50 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5176; toxval_study_source_id=studyid5176_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-spleen-depletion cellular|pathology microscopic-kidney-degeneration|pathology microscopic-kidney-dilatation|pathology microscopic-thymus-necrosis|in life observation-body weight-body weight|in life observation-mortality-mortality|pathology microscopic-thyroid gland-degeneration; dose_level=2; study_year=1998; study_citation=(1998). 'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Chronic Mouse); dsstox_substance_id=DTXSID5021336; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =100 | mg/L | Rat | environmental | short-term; 2 days | short-term | LONG_REF=Experientia44(10): 833-840 Cicurel,L., and B.P. Schmid Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds 1988; TITLE=Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds; AUTHOR=Cicurel,L., and B.P. Schmid; DOI=10.1007/BF01941180; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=94518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Length|Morphology: General morphological changes; STUDY_GROUP=ECOTOX:15606783:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=25bd26acebd67d0acc9869bbb120ac64 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.54 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635218:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_da49ee92956f55fa20eecd1f15b6c980 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | <37.5 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df5e4b0a676289dea97; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Histopathology: Mesenteric lymph node-Artery, Periarteritis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=HESS:15638724:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fef962ab65a22270a4ac2d04121dd7a5 |
ToxValDB ToxRefDB 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =125 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=(1998). \'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Rat Feed); TITLE=NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5171; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-nephropathy|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: pathology microscopic-artery (general)-polyarteritis|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: hematology-platelet-platelet; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708707_15708708_15708709_15708710:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b6d9c99a3c1ce1226102ab5eeee2a3a7 |
| ToxValDB ToxRefDB | LEL | =225 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=(1998). \'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Mouse Feed); TITLE=NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5173; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: organ weight-thymus-absolute|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-glycogen deposition|systemic: hematology-neutrophils-neutrophils|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: organ weight-thymus-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708718_15708719:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a2e32c5b23a747f60dd4cdccfc5211d4 |
| ToxValDB ToxRefDB | LEL | =175 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=(1998). \'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Mouse Feed); TITLE=NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5173; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-glycogen deposition|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: hematology-neutrophils-neutrophils|systemic: hematology-lymphocyte-lymphocyte|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708720_15708721:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1facc26b701aba7c4f538a3ee3ecee74 |
| ToxValDB ToxRefDB | LEL | =300 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=(1998). \'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Mouse Gavage); TITLE=NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5174; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-thymus-depletion lymphoid|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-lung-congestion|systemic: pathology microscopic-spleen-depletion lymphoid; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708723_15708724:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1dd890a80b1bb5682d5b9278a5398e3 |
| ToxValDB ToxRefDB | LEL | =25 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=(1998). \'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Chronic Mouse); TITLE=NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5176; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-hyperactivity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15708729_15708730_15708731_15708732:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_589265b1d35d960fb531015b0cf1d4f0 |
| ToxValDB ToxRefDB | LOAEL | =150 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=(1998). \'NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 473: 1-326. (Subchronic Rat Gavage); TITLE=NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5172; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-artery (general)-polyarteritis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708711_15708712_15708713_15708714:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_da24216b2092ad42389492b54983f5d8 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 0I55128JYK | UNII | - | - | - | chemical | - |