Tocophereth-50

INCI: TOCOPHERETH-50

CAS Number
Not individually assigned (high-MW PEG ether of tocopherol)
Function
Antioxidant, Skin Conditioning, Solubilizer/Emulsifier (very high HLB due to 50-unit PEG chain)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; CIR class review covers tocophereth series

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

PEG impurity controls critical โ€” longer ethoxylation chains require strict 1,4-dioxane and ethylene oxide residual testing; water-soluble delivery may alter active penetration profiles in formulation

โš ๏ธ
Concern Level: Low

Frequently Asked Questions

Is Tocophereth-50 safe in cosmetics?

PEG impurity controls critical โ€” longer ethoxylation chains require strict 1,4-dioxane and ethylene oxide residual testing; water-soluble delivery may alter active penetration profiles in formulation The EU classifies Tocophereth-50 as "permitted". Safety rating: GOOD.

Is Tocophereth-50 allowed in the EU?

Tocophereth-50 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tocophereth-50 do in cosmetics?

Tocophereth-50 functions as: Antioxidant, Skin Conditioning, Solubilizer/Emulsifier (very high HLB due to 50-unit PEG chain). It is classified as a cosmetic ingredient in our database. CAS number: Not individually assigned (high-MW PEG ether of tocopherol).

What is the Margin of Safety for Tocophereth-50?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Tocophereth-50 in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tocophereth-50 in your formulation.