Tocopheryl Retinoate

INCI: TOCOPHERYL RETINOATE

CAS Number
40516-49-2
Function
Antioxidant, Humectant, Skin Conditioning, Skin Conditioning — Emollient
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status restricted
US Notes Not specifically restricted by FDA for cosmetic use; not a drug-classified retinoid when used as ester in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains a retinoate (vitamin A acid ester) moiety — EU retinoid restrictions may apply in leave-on products, especially for pregnant consumers. Monitor evolving SCCS opinions on retinoids

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Tocopheryl Retinoate safe in cosmetics?

Contains a retinoate (vitamin A acid ester) moiety — EU retinoid restrictions may apply in leave-on products, especially for pregnant consumers. Monitor evolving SCCS opinions on retinoids The EU classifies Tocopheryl Retinoate as "permitted". Safety rating: MODERATE.

Is Tocopheryl Retinoate allowed in the EU?

Tocopheryl Retinoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tocopheryl Retinoate do in cosmetics?

Tocopheryl Retinoate functions as: Antioxidant, Humectant, Skin Conditioning, Skin Conditioning — Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 40516-49-2.

What is the Margin of Safety for Tocopheryl Retinoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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