Is Tocopheryl Retinoate safe in cosmetics?
Tocopheryl Retinoate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Tocopheryl Retinoate
INCI: TOCOPHERYL RETINOATE
Tocopheryl Retinoate (CAS 40516-49-2) is a cosmetic cosmetic ingredient functioning as Antioxidant, Humectant, Skin Conditioning, Skin Conditioning — Emollient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 40516-49-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Humectant, Skin Conditioning, Skin Conditioning — Emollient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
InChIKey
RIQIJXOWVAHQES-UNAKLNRMSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted by FDA for cosmetic use; not a drug-classified retinoid when used as ester in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tocopheryl Retinoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Tocopheryl Retinoate.
Chemical Function
Humectant
Softener and conditioner
Antioxidant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL262520
Frequently Asked Questions
Is Tocopheryl Retinoate allowed in the EU?
Tocopheryl Retinoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tocopheryl Retinoate do in cosmetics?
Tocopheryl Retinoate functions as: Antioxidant, Humectant, Skin Conditioning, Skin Conditioning — Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 40516-49-2.
Is Tocopheryl Retinoate used outside cosmetics?
Tocopheryl Retinoate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tocopheryl Retinoate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
TRACHELOSPERMUM JASMINOIDES EXTRACT
Good
Browse nearby
Skin Conditioning
TRAMETES VERSICOLOR EXTRACT
Good
Browse nearby
Hair Conditioning
TRANS, TRANS-2,4-DECADIENAL
Good
Browse nearby
Perfuming
Is Tocopheryl Retinoate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tocopheryl Retinoate in your formulation.