Tocopheryl Succinate

INCI: TOCOPHERYL SUCCINATE

CAS Number
4345-03-3 (d-alpha-tocopheryl succinate)
Function
Antioxidant, Skin Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR concluded safe as used in cosmetics; ฮฑ-tocopherol and ฮฑ-tocopheryl acetate are GRAS food ingredients โ€” succinate ester shares the safety profile

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

One animal study suggested tocopheryl succinate may not prevent photocarcinogenesis and could potentially enhance squamous cell carcinoma incidence, but SCCNFP found the study methodology questionable and concluded no restriction is warranted

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Concern Level: Moderate

Frequently Asked Questions

Is Tocopheryl Succinate safe in cosmetics?

One animal study suggested tocopheryl succinate may not prevent photocarcinogenesis and could potentially enhance squamous cell carcinoma incidence, but SCCNFP found the study methodology questionable and concluded no restriction is warranted The EU classifies Tocopheryl Succinate as "permitted". Safety rating: GOOD.

Is Tocopheryl Succinate allowed in the EU?

Tocopheryl Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tocopheryl Succinate do in cosmetics?

Tocopheryl Succinate functions as: Antioxidant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 4345-03-3 (d-alpha-tocopheryl succinate).

What is the Margin of Safety for Tocopheryl Succinate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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