NOAEL Studies
Cosmetic Ingredient
Toluene NOAEL Studies
INCI: TOLUENE
CAS: 108-88-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =56.5285 | mg/m3 | Human (M/F) | inhalation | acute; 20 minutes | clinical | ATSDR MRLs; row_hash=e2ead2d09b480428; source_hash=ToxValhc_f6d1057e43b56c705444cde54c2e2674; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=15; raw_unit=ppm; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Little CH, Georgiou GM, Shelton MJ, et al. 1999. Clinical and immunological responses in subjects sensitive to solvents. Arch Environ Health 54(1):6-14.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d |
| Regulatory source | LOAEL | =250 | mg/kg/day | Rat (Long-Evans; M) | oral | acute; 1 days | acute | ATSDR MRLs; row_hash=daf8e5b7310213df; source_hash=ToxValhc_f9ce23e886e93bd24d2ad5482745b331; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=250; raw_unit=mg/kg/day; method=gavage; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Dyer RS, Bercegeay MS, Mayo LM. 1988. Acute exposures to p-xylene and toluene alter visual information processing. Neurotoxicol Teratol 10:147-153.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d |
| Regulatory source | NOAEL | =169.586 | mg/m3 | Human (M) | inhalation | chronic; 13.4 years | occupational | ATSDR MRLs; row_hash=1c8bbace2bd91a89; source_hash=ToxValhc_5a6d63445062dbca95f1478041d2c491; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=45; raw_unit=ppm; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Schaper M, Demes P, Zupanic M, et al. 2003. Occupational toluene exposure and auditory function: results from a follow-up study. Ann Occup Hygiene 47(6):493-502. ; Schaper M, Demes P, Kiesswetter E, et al. 2004. Colour vision and occupational toluene exposure: results of repeated examinations. Toxicol Lett 151(1):193-202. ; Schaper M, Seeber A, van Thriel, C. 2008. The effects of toluene plus noise on hearing thresholds: an evaluation based on repeated measurements in the German printing industry. Int J Occup Med Environ Health 21(3):191-200. ; Seeber A, Schaper M, Zupanic M, et al. 2004. Toluene exposure below 50 ppm and cognitive function: a follow-up study with four repeated measurements in rotogravure printing plants. Int Arch Occup Environ Health 77(1):1-9. ; Seeber A, Demes P, Kiesswetter E, et al. 2005. Changes of neurobehavioral and sensory functions due to toluene exposure below 50 ppm? Environ Toxicol Pharmacol 19(3):635-643. ; Zupanic M, Demes P, Seeber A. 2002. Psychomotor performance and subjective symptoms at low level toluene exposure. Occup Environ Med 59(4):263-268.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d |
| Regulatory source | NOAEL | =22 | mg/kg/day | Mouse (CD1; M) | oral | short-term; 28 days | short-term | ATSDR MRLs; row_hash=193e576846971ce7; source_hash=ToxValhc_570c05b503f56f0528f1a4c1a0a59d6e; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=22; raw_unit=mg/kg/day; method=drinking water; effect=immunological; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Hsieh GC, Sharma RP, Parker RD. 1989. Immunotoxicological evaluation of toluene exposure via drinking water in mice. Environ Res 49:93-103. ; Hsieh GC, Parker RD, Sharma RP, et al. 1990a. Subclinical effects of groundwater contaminants. III. Effects of repeated oral exposure to combinations of benzene and toluene on immunologic responses in mice. Arch Toxicol 64:320-328. ; Hsieh GC, Sharma RP, Parker RD. 1991. Hypothalamic-pituitary-adrenocortical axis activity and immune function after oral exposure to benzene and toluene. Immunopharmacol 21:23-31.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d |
| Regulatory source | NOAEL (ADJ) | =46 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=d19f3c50cf3b8a72; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (ADJ): 46 mg/m^3; system=Nervous; basis=Neurological effects in occupationally-exposed workers; point_of_departure=NOAEL (ADJ): 46 mg/m^3; composite_uf=10; confidence=High; dtxsid=DTXSID7021360; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; rfc_last_updated=09/23/2005; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0118_summary.pdf |
| Regulatory source | RfC | =5 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=efc87620845d78be; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=5; system=Nervous; basis=Neurological effects in occupationally-exposed workers; point_of_departure=NOAEL (ADJ): 46 mg/m^3; composite_uf=10; confidence=High; dtxsid=DTXSID7021360; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; rfc_last_updated=09/23/2005; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0118_summary.pdf |
| Regulatory source | BMDL | =238 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=3a88c08392d0d999; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL : 238 mg/kg-day; system=Urinary; basis=Increased kidney weight; point_of_departure=BMDL : 238 mg/kg-day; composite_uf=3000; confidence=Medium; dtxsid=DTXSID7021360; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; rfd_last_updated=09/23/2005; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0118_summary.pdf |
| Regulatory source | RfD | =0.08 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=9bf1d777537dea39; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=8e-2; system=Urinary; basis=Increased kidney weight; point_of_departure=BMDL : 238 mg/kg-day; composite_uf=3000; confidence=Medium; dtxsid=DTXSID7021360; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; rfd_last_updated=09/23/2005; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0118_summary.pdf |
| Regulatory source | reproductive toxicity | 34 | ppm | human | inhalation | chronic | reproductive toxicity | SOURCE_SUBDIR=sccp_o_076; REPORT_TITLE=Opinion on Toluene (its use as a solvent in nail cosmetics); OPINION_NUMBER=SCCP/1029/06; COMMITTEE=Scientific Committee on Cosmetic Products and Non-Food Products intended for Consumers (SCCNFP); REPORT_DATE=10 October 2006; VALUE_TEXT=34; DOSE=A value of 34 ppm (128 mg/m3) was chosen as the point of departure.; EFFECT=______________________________________________________________________ 7 effect of chronic inhalation exposure to toluene. A subset of studies was chosen from which to derive a point of departure for the derivation of the RfC. A value of 34 ppm (128 mg/m3) was chosen as the point of departure. This value is the arithmetic mean of the available NOAELs as identified in Section 5.2.1. This value is lower than the LOAELs identified under human exposure conditions. An RfC of 5 mg/m3 was derived by adjusting the average NOAEL for continuous exposure and application of a 10-fold UF for intra- human variability. Confidence in the database is high; multiple chronic studies in humans are available that examine neurotoxic effects and numerous animal reproductive and developmental studies, as well as a two-generation reproductive toxicity study, exist. There is high confidence in the resulting RfC. The rationale provided for the Choice of Principal Study and Critical Effect (page 70; AR 1) is the following: • A substantial database examini; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"108-88-3","citation":"","dose":"A value of 34 ppm (128 mg/m3) was chosen as the point of departure.","duration":"chronic","effect":"______________________________________________________________________ 7 effect of chronic inhalation exposure to toluene. A subset of studies was chosen from which to derive a point of departure for the derivation of the RfC. A value of 34 ppm (128 mg/m3) was chosen as the point of departure. This value is the arithmetic mean of the available NOAELs as identified in Section 5.2.1. This value is lower than the LOAELs identified under human exposure conditions. An RfC of 5 mg/m3 was derived by adjusting the average NOAEL for continuous exposure and application of a 10-fold UF for intra- human variability. Confidence in the database is high; multiple chronic studies in humans are available that examine neurotoxic effects and numerous animal reproductive and developmental studies, as well as a two-generation reproductive toxicity study, exist. There is high confidence in the resulting RfC. The rationale provided for the Choice of Principal Study and Critical Effect (page 70; AR 1) is the following: • A substantial database examini","endpoint":"reproductive toxicity","ingredient":"s classified","loael_value":"","noael_unit":"ppm","noael_value":"34","page":7,"route":"inhalation","species":"human","study_id":"sccp_o_076_noael_001"} |
California Proposition 65 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 MADL | SQEinhalation=13000; oral=7000 | ug/day | - | - | 1991-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | SQEinhalation=13000; oral=7000 | ug/day | - | - | 1991-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | SQEinhalation=13000; oral=7000 | ug/day | - | - | 1991-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | SQEinhalation=13000; oral=7000 | ug/day | - | - | 1991-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | LCinhalation=13000; oral=7000 | ug/day | - | - | 2009-08-07 | Maximum allowable dose level | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | LCinhalation=13000; oral=7000 | ug/day | - | - | 2009-08-07 | Maximum allowable dose level | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | LCinhalation=13000; oral=7000 | ug/day | - | - | 2009-08-07 | Maximum allowable dose level | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | LCinhalation=13000; oral=7000 | ug/day | - | - | 2009-08-07 | Maximum allowable dose level | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental | listing type | - | - | 1991-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental | listing type | - | - | 1991-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental | listing type | - | - | 1991-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental | listing type | - | - | 1991-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1991-01-01","listing_mechanism":"SQE","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCfemale | listing type | - | - | 2009-08-07 | California Proposition 65 listing | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCfemale | listing type | - | - | 2009-08-07 | California Proposition 65 listing | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCfemale | listing type | - | - | 2009-08-07 | California Proposition 65 listing | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCfemale | listing type | - | - | 2009-08-07 | California Proposition 65 listing | {"cancer_reproductive":"female","listed_date":"2009-08-07","listing_mechanism":"LC","madl":"inhalation=13000; oral=7000","nsrl":null,"source_table":"prop65_listings"} |
ECHA 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 1250 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=50be13ba-be0f-4ac3-a152-1271322179f5.i6z; document=5efc8cf3-c854-45ab-aa5b-306f85cf36c5_50be13ba-be0f-4ac3-a152-1271322179f5.i6d; document_key=5efc8cf3-c854-45ab-aa5b-306f85cf36c5/50be13ba-be0f-4ac3-a152-1271322179f5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=2a978bd3-d0e0-46eb-9be3-abf1c2d8c959 |
| ECHA | LOAEL | 1250 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=50be13ba-be0f-4ac3-a152-1271322179f5.i6z; document=5efc8cf3-c854-45ab-aa5b-306f85cf36c5_50be13ba-be0f-4ac3-a152-1271322179f5.i6d; document_key=5efc8cf3-c854-45ab-aa5b-306f85cf36c5/50be13ba-be0f-4ac3-a152-1271322179f5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=2a978bd3-d0e0-46eb-9be3-abf1c2d8c959 |
| ECHA | LOAEL | 1250 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=50be13ba-be0f-4ac3-a152-1271322179f5.i6z; document=5efc8cf3-c854-45ab-aa5b-306f85cf36c5_50be13ba-be0f-4ac3-a152-1271322179f5.i6d; document_key=5efc8cf3-c854-45ab-aa5b-306f85cf36c5/50be13ba-be0f-4ac3-a152-1271322179f5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=2a978bd3-d0e0-46eb-9be3-abf1c2d8c959 |
| ECHA | NOAEL | 625 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=50be13ba-be0f-4ac3-a152-1271322179f5.i6z; document=5efc8cf3-c854-45ab-aa5b-306f85cf36c5_50be13ba-be0f-4ac3-a152-1271322179f5.i6d; document_key=5efc8cf3-c854-45ab-aa5b-306f85cf36c5/50be13ba-be0f-4ac3-a152-1271322179f5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=dd582503-18ca-4758-9305-4c942ca7482c |
| ECHA | NOAEL | 625 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=50be13ba-be0f-4ac3-a152-1271322179f5.i6z; document=5efc8cf3-c854-45ab-aa5b-306f85cf36c5_50be13ba-be0f-4ac3-a152-1271322179f5.i6d; document_key=5efc8cf3-c854-45ab-aa5b-306f85cf36c5/50be13ba-be0f-4ac3-a152-1271322179f5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=dd582503-18ca-4758-9305-4c942ca7482c |
| ECHA | NOAEL | 625 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=50be13ba-be0f-4ac3-a152-1271322179f5.i6z; document=5efc8cf3-c854-45ab-aa5b-306f85cf36c5_50be13ba-be0f-4ac3-a152-1271322179f5.i6d; document_key=5efc8cf3-c854-45ab-aa5b-306f85cf36c5/50be13ba-be0f-4ac3-a152-1271322179f5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=dd582503-18ca-4758-9305-4c942ca7482c |
| ECHA | LOAEL | =1250 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb1e4b0a7c65d1ca85b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14991/7/6/2?documentUUID=de39c08d-119d-40f4-ba1d-8b7afb8cc83e; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829995_15829996_15833475_15833476_15834412_15834413_15839953_15839954_15840653_15840654_15845234_15845235:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7777a7b58329d1c509515eb6ea10e5f |
| ECHA | NOAEC | =1130.57 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27739?documentUUID=88f01a7f-ed58-48ad-9e44-d295d2731630; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816178_15816179_15818291_15818292_15819043_15819044_15819104_15819105_15819251_15819252_15819253_15819254_15819604_15819605_15819926_15819927:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15d27a14069ee0c98f744e191f635043 |
| ECHA | NOAEC | =1131 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27739?documentUUID=88f01a7f-ed58-48ad-9e44-d295d2731630; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816178_15816179_15818291_15818292_15819043_15819044_15819104_15819105_15819251_15819252_15819253_15819254_15819604_15819605_15819926_15819927:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70a03cf9f62919d7e8b29cc193b16bc6 |
| ECHA | NOAEC | =1884.28 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21aeb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27279?documentUUID=77239c84-1e75-46ad-a4c5-63b497d4993d; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15854997_15855014_15855899_15855912_15856631_15856638_15856838_15856840:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e3940f5042df2766505e07f5c6f295f |
| ECHA | NOAEC | =2261.14 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c921e4b0a7c65d21b9f1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14991/7/9/2?documentUUID=de39c08d-119d-40f4-ba1d-8b7afb8cc83e; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855015_15855913:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_696e97fdb2d0b97c31dd9f92a8c68bae |
| ECHA | NOAEC | =1875 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21aeb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27279?documentUUID=77239c84-1e75-46ad-a4c5-63b497d4993d; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15854997_15855014_15855899_15855912_15856631_15856638_15856838_15856840:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4cbb5ea21d4b6b8422876e4496cd9d70 |
| ECHA | NOAEC | =2261 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c921e4b0a7c65d21b9f1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14991/7/9/2?documentUUID=de39c08d-119d-40f4-ba1d-8b7afb8cc83e; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855015_15855913:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3d09cb9c9a609e484bbe46078cae7fb9 |
| ECHA | NOAEC | =7537.13 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21aeb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27279?documentUUID=77239c84-1e75-46ad-a4c5-63b497d4993d; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15854997_15855014_15855899_15855912_15856631_15856638_15856838_15856840:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f97f8abf238ff76e80e3b9e2f3a042f2 |
| ECHA | NOAEC | =7500 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21aeb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27279?documentUUID=77239c84-1e75-46ad-a4c5-63b497d4993d; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15854997_15855014_15855899_15855912_15856631_15856638_15856838_15856840:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_327a06bd44170fa693b14d0fe9c07ed9 |
| ECHA | NOAEL | =625 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb1e4b0a7c65d1ca85b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14991/7/6/2?documentUUID=de39c08d-119d-40f4-ba1d-8b7afb8cc83e; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829995_15829996_15833475_15833476_15834412_15834413_15839953_15839954_15840653_15840654_15845234_15845235:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4cb1870103ac793b97f1f1fa9fbc906c |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
WHO/JECFA 64 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =10 | ppm | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=0e40c3787f82b5a6; raw_unit=ppm; context=The LOAEL for deterioration in the perceived air quality and increased odour level is 10 ppm. |
| WHO/JECFA | LOAEL | =10 | ppm | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=0e40c3787f82b5a6; raw_unit=ppm; context=The LOAEL for deterioration in the perceived air quality and increased odour level is 10 ppm. |
| WHO/JECFA | LOAEL | =10 | ppm | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=0e40c3787f82b5a6; raw_unit=ppm; context=The LOAEL for deterioration in the perceived air quality and increased odour level is 10 ppm. |
| WHO/JECFA | LOAEL | =10 | ppm | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=0e40c3787f82b5a6; raw_unit=ppm; context=The LOAEL for deterioration in the perceived air quality and increased odour level is 10 ppm. |
| WHO/JECFA | LOAEL | =100 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a05ac2b8bf091a7d; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | LOAEL | =100 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a05ac2b8bf091a7d; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | LOAEL | =100 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a05ac2b8bf091a7d; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | LOAEL | =100 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a05ac2b8bf091a7d; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | LOAEL | =281 | mg/m3 | Human | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=01df48a0a5cb3ba9; raw_unit=mg/m3; context=or inhalation of 281 mg/m3 (75 ppm) and 562 mg/m3 (150 ppm) by volunteers for 7 hours have resulted in significantly poorer results in a number of performance tests, indicating a LOAEL of 281 mg/m3 (75 ppm) for these tests. |
| WHO/JECFA | LOAEL | =281 | mg/m3 | Human | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=01df48a0a5cb3ba9; raw_unit=mg/m3; context=or inhalation of 281 mg/m3 (75 ppm) and 562 mg/m3 (150 ppm) by volunteers for 7 hours have resulted in significantly poorer results in a number of performance tests, indicating a LOAEL of 281 mg/m3 (75 ppm) for these tests. |
| WHO/JECFA | LOAEL | =281 | mg/m3 | Human | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=01df48a0a5cb3ba9; raw_unit=mg/m3; context=or inhalation of 281 mg/m3 (75 ppm) and 562 mg/m3 (150 ppm) by volunteers for 7 hours have resulted in significantly poorer results in a number of performance tests, indicating a LOAEL of 281 mg/m3 (75 ppm) for these tests. |
| WHO/JECFA | LOAEL | =281 | mg/m3 | Human | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=01df48a0a5cb3ba9; raw_unit=mg/m3; context=or inhalation of 281 mg/m3 (75 ppm) and 562 mg/m3 (150 ppm) by volunteers for 7 hours have resulted in significantly poorer results in a number of performance tests, indicating a LOAEL of 281 mg/m3 (75 ppm) for these tests. |
| WHO/JECFA | LOAEL | =1000 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=e4435bdab4cdbe10; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | LOAEL | =1000 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=e4435bdab4cdbe10; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | LOAEL | =1000 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=e4435bdab4cdbe10; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | LOAEL | =1000 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=e4435bdab4cdbe10; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | LOAEL | =1200 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=9c42375f92dcb980; raw_unit=ppm; context=17 Thus, the LOAEL for the behavioural effects is 1200 ppm (4500 mg/m3) and a NOAEL cannot be established since lower exposure levels were not investigated. |
| WHO/JECFA | LOAEL | =1200 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=9c42375f92dcb980; raw_unit=ppm; context=17 Thus, the LOAEL for the behavioural effects is 1200 ppm (4500 mg/m3) and a NOAEL cannot be established since lower exposure levels were not investigated. |
| WHO/JECFA | LOAEL | =1200 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=9c42375f92dcb980; raw_unit=ppm; context=17 Thus, the LOAEL for the behavioural effects is 1200 ppm (4500 mg/m3) and a NOAEL cannot be established since lower exposure levels were not investigated. |
| WHO/JECFA | LOAEL | =1200 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=9c42375f92dcb980; raw_unit=ppm; context=17 Thus, the LOAEL for the behavioural effects is 1200 ppm (4500 mg/m3) and a NOAEL cannot be established since lower exposure levels were not investigated. |
| WHO/JECFA | LOAEL | =3750 | mg/m3 | Rat | - | 2 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=67cf61bcbc57dec4; raw_unit=mg/m3; context=Ls from animal studies Exposure level Exposure duration Species Effects Reference 30 000 mg/ m3 8000 ppm 4-6.5 h Rat lethal (LD50) 11, 19, 122, 146 3750 mg/m3 1000 ppm 2 weeks Rat LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity |
| WHO/JECFA | LOAEL | =3750 | mg/m3 | Rat | - | 2 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=67cf61bcbc57dec4; raw_unit=mg/m3; context=Ls from animal studies Exposure level Exposure duration Species Effects Reference 30 000 mg/ m3 8000 ppm 4-6.5 h Rat lethal (LD50) 11, 19, 122, 146 3750 mg/m3 1000 ppm 2 weeks Rat LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity |
| WHO/JECFA | LOAEL | =3750 | mg/m3 | Rat | - | 2 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=67cf61bcbc57dec4; raw_unit=mg/m3; context=Ls from animal studies Exposure level Exposure duration Species Effects Reference 30 000 mg/ m3 8000 ppm 4-6.5 h Rat lethal (LD50) 11, 19, 122, 146 3750 mg/m3 1000 ppm 2 weeks Rat LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity |
| WHO/JECFA | LOAEL | =3750 | mg/m3 | Rat | - | 2 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=67cf61bcbc57dec4; raw_unit=mg/m3; context=Ls from animal studies Exposure level Exposure duration Species Effects Reference 30 000 mg/ m3 8000 ppm 4-6.5 h Rat lethal (LD50) 11, 19, 122, 146 3750 mg/m3 1000 ppm 2 weeks Rat LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity |
| WHO/JECFA | NOAEL | =5 | mg/m3 | Human | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=94bf5ed6a3f63977; raw_unit=mg/m3; context=nternal controls, 190 external controls work place Increased rate of spontaneous abortion 105 150 mg/m3 40 ppm 16 experimentally exposed subjects, serving as their own control 6 h NOAEL for irritation of the eyes and nose, headache, dizziness, and feeling of intoxication 4 37,5 mg/m3 10 ppm 16 experimentally exposed subjects, serving as their own control 6 h LOAEL for deterioration in the perceived air quality and increased odour level 4 30 Table 5 includes the human studies, which are considered the most relevant for description of the i |
| WHO/JECFA | NOAEL | =5 | mg/m3 | Human | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=94bf5ed6a3f63977; raw_unit=mg/m3; context=nternal controls, 190 external controls work place Increased rate of spontaneous abortion 105 150 mg/m3 40 ppm 16 experimentally exposed subjects, serving as their own control 6 h NOAEL for irritation of the eyes and nose, headache, dizziness, and feeling of intoxication 4 37,5 mg/m3 10 ppm 16 experimentally exposed subjects, serving as their own control 6 h LOAEL for deterioration in the perceived air quality and increased odour level 4 30 Table 5 includes the human studies, which are considered the most relevant for description of the i |
| WHO/JECFA | NOAEL | =5 | mg/m3 | Human | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=94bf5ed6a3f63977; raw_unit=mg/m3; context=nternal controls, 190 external controls work place Increased rate of spontaneous abortion 105 150 mg/m3 40 ppm 16 experimentally exposed subjects, serving as their own control 6 h NOAEL for irritation of the eyes and nose, headache, dizziness, and feeling of intoxication 4 37,5 mg/m3 10 ppm 16 experimentally exposed subjects, serving as their own control 6 h LOAEL for deterioration in the perceived air quality and increased odour level 4 30 Table 5 includes the human studies, which are considered the most relevant for description of the i |
| WHO/JECFA | NOAEL | =5 | mg/m3 | Human | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=94bf5ed6a3f63977; raw_unit=mg/m3; context=nternal controls, 190 external controls work place Increased rate of spontaneous abortion 105 150 mg/m3 40 ppm 16 experimentally exposed subjects, serving as their own control 6 h NOAEL for irritation of the eyes and nose, headache, dizziness, and feeling of intoxication 4 37,5 mg/m3 10 ppm 16 experimentally exposed subjects, serving as their own control 6 h LOAEL for deterioration in the perceived air quality and increased odour level 4 30 Table 5 includes the human studies, which are considered the most relevant for description of the i |
| WHO/JECFA | NOAEL | =40 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=7a94f897ac98ed49; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | NOAEL | =40 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=7a94f897ac98ed49; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | NOAEL | =40 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=7a94f897ac98ed49; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | NOAEL | =40 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=7a94f897ac98ed49; raw_unit=ppm; context=For eye irritation, headache, and feeling of intoxication the LOAEL is 100 ppm and the NOAEL is 40 ppm. |
| WHO/JECFA | NOAEL | =150 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=df551225084d559e; raw_unit=mg/m3; context=A NOAEL of 150 mg/m3 (40 ppm) for performance tests can be deducted from the study of Andersen et al.(4). |
| WHO/JECFA | NOAEL | =150 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=df551225084d559e; raw_unit=mg/m3; context=A NOAEL of 150 mg/m3 (40 ppm) for performance tests can be deducted from the study of Andersen et al.(4). |
| WHO/JECFA | NOAEL | =150 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=df551225084d559e; raw_unit=mg/m3; context=A NOAEL of 150 mg/m3 (40 ppm) for performance tests can be deducted from the study of Andersen et al.(4). |
| WHO/JECFA | NOAEL | =150 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=df551225084d559e; raw_unit=mg/m3; context=A NOAEL of 150 mg/m3 (40 ppm) for performance tests can be deducted from the study of Andersen et al.(4). |
| WHO/JECFA | NOAEL | =300 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=299f8731fd9af01b; raw_unit=ppm; context=The NOAEL was 300 ppm. |
| WHO/JECFA | NOAEL | =300 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=299f8731fd9af01b; raw_unit=ppm; context=The NOAEL was 300 ppm. |
| WHO/JECFA | NOAEL | =300 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=299f8731fd9af01b; raw_unit=ppm; context=The NOAEL was 300 ppm. |
| WHO/JECFA | NOAEL | =300 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=299f8731fd9af01b; raw_unit=ppm; context=The NOAEL was 300 ppm. |
| WHO/JECFA | NOAEL | =400 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=14eabc904405c37a; raw_unit=ppm; context=The NOAEL was 400 ppm (1500 mg/m3), but the daily exposure periods were limited to 3 hours. |
| WHO/JECFA | NOAEL | =400 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=14eabc904405c37a; raw_unit=ppm; context=The NOAEL was 400 ppm (1500 mg/m3), but the daily exposure periods were limited to 3 hours. |
| WHO/JECFA | NOAEL | =400 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=14eabc904405c37a; raw_unit=ppm; context=The NOAEL was 400 ppm (1500 mg/m3), but the daily exposure periods were limited to 3 hours. |
| WHO/JECFA | NOAEL | =400 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=14eabc904405c37a; raw_unit=ppm; context=The NOAEL was 400 ppm (1500 mg/m3), but the daily exposure periods were limited to 3 hours. |
| WHO/JECFA | NOAEL | =600 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=1f2101a52a6a3c02; raw_unit=ppm; context=The NOAEL was 600 ppm (2250 mg/m3). |
| WHO/JECFA | NOAEL | =600 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=1f2101a52a6a3c02; raw_unit=ppm; context=The NOAEL was 600 ppm (2250 mg/m3). |
| WHO/JECFA | NOAEL | =600 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=1f2101a52a6a3c02; raw_unit=ppm; context=The NOAEL was 600 ppm (2250 mg/m3). |
| WHO/JECFA | NOAEL | =600 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=1f2101a52a6a3c02; raw_unit=ppm; context=The NOAEL was 600 ppm (2250 mg/m3). |
| WHO/JECFA | NOAEL | =625 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a547e56f69749863; raw_unit=mg/kg; context=The dose level 625 mg/kg is considered the NOAEL. |
| WHO/JECFA | NOAEL | =625 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a547e56f69749863; raw_unit=mg/kg; context=The dose level 625 mg/kg is considered the NOAEL. |
| WHO/JECFA | NOAEL | =625 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a547e56f69749863; raw_unit=mg/kg; context=The dose level 625 mg/kg is considered the NOAEL. |
| WHO/JECFA | NOAEL | =625 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=a547e56f69749863; raw_unit=mg/kg; context=The dose level 625 mg/kg is considered the NOAEL. |
| WHO/JECFA | NOAEL | =700 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=ae3ccfc32ffe4f7b; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | NOAEL | =700 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=ae3ccfc32ffe4f7b; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | NOAEL | =700 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=ae3ccfc32ffe4f7b; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | NOAEL | =700 | ppm | - | - | 2 weeks | Toxicology study | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=ae3ccfc32ffe4f7b; raw_unit=ppm; context=A LOAEL of 1000 ppm (14h/day, 2 weeks) and a NOAEL of 700 ppm (14h/day, 16 weeks) was found (125). |
| WHO/JECFA | NOAEL | =1125 | mg/m3 | Rat | - | 2 years | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=48e805eedf4d09a0; raw_unit=mg/m3; context=auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for general toxicity 45 Table 5. |
| WHO/JECFA | NOAEL | =1125 | mg/m3 | Rat | - | 2 years | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=48e805eedf4d09a0; raw_unit=mg/m3; context=auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for general toxicity 45 Table 5. |
| WHO/JECFA | NOAEL | =1125 | mg/m3 | Rat | - | 2 years | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=48e805eedf4d09a0; raw_unit=mg/m3; context=auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for general toxicity 45 Table 5. |
| WHO/JECFA | NOAEL | =1125 | mg/m3 | Rat | - | 2 years | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=48e805eedf4d09a0; raw_unit=mg/m3; context=auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for general toxicity 45 Table 5. |
| WHO/JECFA | NOAEL | =2250 | mg/m3 | Rat | - | 16 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=62162855a27dee17; raw_unit=mg/m3; context=at LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for g |
| WHO/JECFA | NOAEL | =2250 | mg/m3 | Rat | - | 16 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=62162855a27dee17; raw_unit=mg/m3; context=at LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for g |
| WHO/JECFA | NOAEL | =2250 | mg/m3 | Rat | - | 16 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=62162855a27dee17; raw_unit=mg/m3; context=at LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for g |
| WHO/JECFA | NOAEL | =2250 | mg/m3 | Rat | - | 16 weeks | Chronic toxicity | document_id=kemi_kemi_ah2000_19; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 125. Toluene; path=mirror/documents/kemi/kemi/ah2000_19.pdf; row_hash=62162855a27dee17; raw_unit=mg/m3; context=at LOAEL for auditory toxicity 125 3750 mg/m3 1000 ppm gestation day 9-21 Rat LOAEL for reduced birth weight and retarded postnatal development 156 2625 mg/m3 700 ppm 16 weeks Rat NOAEL for auditory toxicity 125 2250 mg/m3 600 ppm 2 years Rat LOAEL for nasal toxicity and general toxicity (nasal toxicity and stomach ulcers) 56 2250 mg/m3 600 ppm gestation day 9-21 Rat NOAEL for reduced birth weight and retarded postnatal development 156 1125 mg/m3 300 ppm 2 years Rat NOAEL for g |
NTP ICE acute inhalation 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 28.1 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3887; Record_ID=acute_inhalation_2656; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15538/7/3/3/?documentUUID=11f0e706-2917-4a3c-8275-102e1acbff68; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE acute inhalation | LC50 | 30 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3888; Record_ID=acute_inhalation_2658; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=30; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15538/7/3/3/?documentUUID=11f0e706-2917-4a3c-8275-102e1acbff68; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE acute inhalation | LC50 | 49 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3889; Record_ID=acute_inhalation_1146; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=49; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE acute inhalation | LC50 | 25.7 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3890; Record_ID=acute_inhalation_2657; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=25.7; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15538/7/3/3/?documentUUID=11f0e706-2917-4a3c-8275-102e1acbff68; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE acute inhalation | LC50 | 45.9477 | mg/L | - | Inhalation | Duration=6.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3891; Record_ID=acute_inhalation_1912; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=45.9477; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE acute inhalation | LC50 | 68.9215 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3892; Record_ID=acute_inhalation_1913; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=68.9215; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE acute inhalation | LC50 | 37.662 | mg/L | - | Inhalation | Duration=2-2.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3893; Record_ID=acute_inhalation_1914; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=37.662; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE acute inhalation | LC50 | 100.5576 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3894; Record_ID=acute_inhalation_1911; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=100.5576; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >2600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_783; row=11668; data_type=In Vivo; mixture=Chemical; chemical_name=Toluene; preferred_name=Toluene; dtxsid=DTXSID7021360; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021360; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_784; row=11669; data_type=In Vivo; mixture=Chemical; chemical_name=Toluene; preferred_name=Toluene; dtxsid=DTXSID7021360; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021360; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5580 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_786; row=11671; data_type=In Vivo; mixture=Chemical; chemical_name=Toluene; preferred_name=Toluene; dtxsid=DTXSID7021360; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021360; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <7500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_787; row=11672; data_type=In Vivo; mixture=Chemical; chemical_name=Toluene; preferred_name=Toluene; dtxsid=DTXSID7021360; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021360; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =636 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_782; row=11673; data_type=In Vivo; mixture=Chemical; chemical_name=Toluene; preferred_name=Toluene; dtxsid=DTXSID7021360; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021360; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 17.66 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2756; Record_ID=adme_parameters_683; Data_Type=Measured; DTXSID=DTXSID7021360; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=17.66; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE adme parameters | Clint | 95.77 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=2757; Record_ID=adme_parameters_683; Data_Type=Measured; DTXSID=DTXSID7021360; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=95.77; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE adme parameters | Fu | 0.3433 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=2755; Record_ID=adme_parameters_683; Data_Type=Measured; DTXSID=DTXSID7021360; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.3433; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE adme parameters | Fu | 0.3 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2758; Record_ID=adme_parameters_683; Data_Type=Measured; DTXSID=DTXSID7021360; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.3; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, ECVAM; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=7954; Record_ID=cancer_5017; Data_Type=WOE; Formulation_Name=Toluene; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/65; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE cancer | Top dose | 1200 | ppm | Rat | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7946; Record_ID=cancer_5019; Data_Type=In Vivo; Formulation_Name=Toluene; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1200; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Inhalation; Reference=TR-371; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr371/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
NTP ICE eye irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 9 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2018; Record_ID=eye_irritation_194; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=9; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2020; Record_ID=eye_irritation_101; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE eye irritation | Intensity | 0.02 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2022; Record_ID=eye_irritation_1254; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Vitrigel; Endpoint=Intensity; Response=0.02; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE eye irritation | Lag time | 140 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2019; Record_ID=eye_irritation_1254; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Vitrigel; Endpoint=Lag time; Response=140; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
| NTP ICE eye irritation | Plateau level | 0 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2021; Record_ID=eye_irritation_1254; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7021360; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021360; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021360 |
SCCS Opinion 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =34 | ppm | human | inhalation | chronic | reproductive toxicity | {"dose":"A value of 34 ppm (128 mg/m3) was chosen as the point of departure.","effect":"______________________________________________________________________ 7 effect of chronic inhalation exposure to toluene. A subset of studies was chosen from which to derive a point of departure for the derivation of the RfC. A value of 34 ppm (128 mg/m3) was chosen as the point of departure. This value is the arithmetic mean of the available NOAELs as identified in Section 5.2.1. This value is lower than the LOAELs identified under human exposure conditions. An RfC of 5 mg/m3 was derived by adjusting the average NOAEL for continuous exposure and application of a 10-fold UF for intra- human variability. Confidence in the database is high; multiple chronic studies in humans are available that examine neurotoxic effects and numerous animal reproductive and developmental studies, as well as a two-generation reproductive toxicity study, exist. There is high confidence in the resulting RfC. The rationale provided for the Choice of Principal Study and Critical Effect (page 70; AR 1) is the following: • A substantial database examini","page":7,"pdf":"sccp_o_076.pdf","row_type":"noael_study","study_id":"sccp_o_076_noael_001"} |
| SCCS Opinion | NOAEL | =34 | ppm | human | inhalation | chronic | reproductive toxicity | {"dose":"A value of 34 ppm (128 mg/m3) was chosen as the point of departure.","effect":"______________________________________________________________________ 7 effect of chronic inhalation exposure to toluene. A subset of studies was chosen from which to derive a point of departure for the derivation of the RfC. A value of 34 ppm (128 mg/m3) was chosen as the point of departure. This value is the arithmetic mean of the available NOAELs as identified in Section 5.2.1. This value is lower than the LOAELs identified under human exposure conditions. An RfC of 5 mg/m3 was derived by adjusting the average NOAEL for continuous exposure and application of a 10-fold UF for intra- human variability. Confidence in the database is high; multiple chronic studies in humans are available that examine neurotoxic effects and numerous animal reproductive and developmental studies, as well as a two-generation reproductive toxicity study, exist. There is high confidence in the resulting RfC. The rationale provided for the Choice of Principal Study and Critical Effect (page 70; AR 1) is the following: • A substantial database examini","page":7,"pdf":"sccp_o_076.pdf","row_type":"noael_study","study_id":"sccp_o_076_noael_001"} |
| SCCS Opinion | NOAEL | =34 | ppm | human | inhalation | chronic | reproductive toxicity | {"dose":"A value of 34 ppm (128 mg/m3) was chosen as the point of departure.","effect":"______________________________________________________________________ 7 effect of chronic inhalation exposure to toluene. A subset of studies was chosen from which to derive a point of departure for the derivation of the RfC. A value of 34 ppm (128 mg/m3) was chosen as the point of departure. This value is the arithmetic mean of the available NOAELs as identified in Section 5.2.1. This value is lower than the LOAELs identified under human exposure conditions. An RfC of 5 mg/m3 was derived by adjusting the average NOAEL for continuous exposure and application of a 10-fold UF for intra- human variability. Confidence in the database is high; multiple chronic studies in humans are available that examine neurotoxic effects and numerous animal reproductive and developmental studies, as well as a two-generation reproductive toxicity study, exist. There is high confidence in the resulting RfC. The rationale provided for the Choice of Principal Study and Critical Effect (page 70; AR 1) is the following: • A substantial database examini","page":7,"pdf":"sccp_o_076.pdf","row_type":"noael_study","study_id":"sccp_o_076_noael_001"} |
| SCCS Opinion | NOAEL | =34 | ppm | human | inhalation | chronic | reproductive toxicity | {"dose":"A value of 34 ppm (128 mg/m3) was chosen as the point of departure.","effect":"______________________________________________________________________ 7 effect of chronic inhalation exposure to toluene. A subset of studies was chosen from which to derive a point of departure for the derivation of the RfC. A value of 34 ppm (128 mg/m3) was chosen as the point of departure. This value is the arithmetic mean of the available NOAELs as identified in Section 5.2.1. This value is lower than the LOAELs identified under human exposure conditions. An RfC of 5 mg/m3 was derived by adjusting the average NOAEL for continuous exposure and application of a 10-fold UF for intra- human variability. Confidence in the database is high; multiple chronic studies in humans are available that examine neurotoxic effects and numerous animal reproductive and developmental studies, as well as a two-generation reproductive toxicity study, exist. There is high confidence in the resulting RfC. The rationale provided for the Choice of Principal Study and Critical Effect (page 70; AR 1) is the following: • A substantial database examini","page":7,"pdf":"sccp_o_076.pdf","row_type":"noael_study","study_id":"sccp_o_076_noael_001"} |
ToxValDB ATSDR MRLs 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =56.5285 | mg/m3 | Human | inhalation | acute; 20 minutes | clinical | LONG_REF=Little CH, Georgiou GM, Shelton MJ, et al. 1999. Clinical and immunological responses in subjects sensitive to solvents. Arch Environ Health 54(1):6-14.; TITLE=Clinical and immunological responses in subjects sensitive to solvents; AUTHOR=Little CH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp56.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447823:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f6d1057e43b56c705444cde54c2e2674 |
| ToxValDB ATSDR MRLs | LOAEL | =250 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Dyer RS, Bercegeay MS, Mayo LM. 1988. Acute exposures to p-xylene and toluene alter visual information processing. Neurotoxicol Teratol 10:147-153.; TITLE=Acute exposures to p-xylene and toluene alter visual information processing; AUTHOR=Dyer RS; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp56.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447825:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f9ce23e886e93bd24d2ad5482745b331 |
| ToxValDB ATSDR MRLs | MRL | =7.53713 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs_dup_-_15447253_15447254:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fc94768658cd10f2cd72645e1cceac5 |
| ToxValDB ATSDR MRLs | MRL | =3.76857 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs_dup_-_15447253_15447254:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28244d0cf65ef22eb50ec6f6738b37fb |
| ToxValDB ATSDR MRLs | MRL | =0.8 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=neurological in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447255_15447256:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9d8f9f6b631e2bbd22573583cbfd6d1 |
| ToxValDB ATSDR MRLs | MRL | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=immunological in male mice; STUDY_GROUP=ATSDR MRLs_dup_-_15447255_15447256:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7db971371c46b3ea378aeb648413b8d2 |
| ToxValDB ATSDR MRLs | NOAEL | =169.586 | mg/m3 | Human | inhalation | chronic; 13.4 years | occupational | LONG_REF=Schaper M, Demes P, Zupanic M, et al. 2003. Occupational toluene exposure and auditory function: results from a follow-up study. Ann Occup Hygiene 47(6):493-502. ; Schaper M, Demes P, Kiesswetter E, et al. 2004. Colour vision and occupational toluene exposure: results of repeated examinations. Toxicol Lett 151(1):193-202. ; Schaper M, Seeber A, van Thriel, C. 2008. The effects of toluene plus noise on hearing thresholds: an evaluation based on repeated measurements in the German printing industry. Int J Occup Med Environ Health 21(3):191-200. ; Seeber A, Schaper M, Zupanic M, et al. 2004. Toluene exposure below 50 ppm and cognitive function: a follow-up study with four repeated measurements in rotogravure printing plants. Int Arch Occup Environ Health 77(1):1-9. ; Seeber A, Demes P, Kiesswetter E, et al. 2005. Changes of neurobehavioral and sensory functions due to toluene exposure below 50 ppm? Environ Toxicol Pharmacol 19(3):635-643. ; Zupanic M, Demes P, Seeber A. 2002. Psychomotor performance and subjective symptoms at low level toluene exposure. Occup Environ Med 59(4):263-268.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp56.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447824:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5a6d63445062dbca95f1478041d2c491 |
| ToxValDB ATSDR MRLs | NOAEL | =22 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Hsieh GC, Sharma RP, Parker RD. 1989. Immunotoxicological evaluation of toluene exposure via drinking water in mice. Environ Res 49:93-103. ; Hsieh GC, Parker RD, Sharma RP, et al. 1990a. Subclinical effects of groundwater contaminants. III. Effects of repeated oral exposure to combinations of benzene and toluene on immunologic responses in mice. Arch Toxicol 64:320-328. ; Hsieh GC, Sharma RP, Parker RD. 1991. Hypothalamic-pituitary-adrenocortical axis activity and immune function after oral exposure to benzene and toluene. Immunopharmacol 21:23-31.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d58581d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp56.pdf; TOXICOLOGICAL_EFFECT=immunological; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447826:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_570c05b503f56f0528f1a4c1a0a59d6e |
ToxValDB AU DWG 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB AU DWG | NOEL | =312 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP (National Toxicology Program) United States Department of Health and Human Services (1990) Toxicology and carcinogenesis studies of toluene in F344/N rats and B6C3F1 mice. NTP Report No 371. NIH Publication No. 90 2826; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c82db5e4b02565fc7d237c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nhmrc.gov.au; SUBSOURCE_URL=https://www.nhmrc.gov.au/sites/default/files/documents/attachments/publications/Australian_Drinking_Water_Guidelines_ADWG_V3-8_Sep2022.pdf; TOXICOLOGICAL_EFFECT=increased liver weights at doses from 625 mg/kg body weight per day (; STUDY_GROUP=AU DWG:15951783:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d7255d8e7cb00d5721a2b831b19851f |
ToxValDB Alaska DEC 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfC | =5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445782:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0ffe99a0ba2bb5d6d39bd28f53305a20 |
| ToxValDB Alaska DEC | RfC | =5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445782:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0ffe99a0ba2bb5d6d39bd28f53305a20 |
| ToxValDB Alaska DEC | RfD | =0.064 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445779:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=40be0c3f9fb0f6a7826d4f0f56951a6e |
| ToxValDB Alaska DEC | RfD | =0.08 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445780:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0425a96e845014c7cee15b0f1bd09438 |
| ToxValDB Alaska DEC | RfD | =1.43 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445781:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=65ddae7835f597973438b01e4d93220e |
| ToxValDB Alaska DEC | RfD | =0.064 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445779:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=40be0c3f9fb0f6a7826d4f0f56951a6e |
| ToxValDB Alaska DEC | RfD | =0.08 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445780:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0425a96e845014c7cee15b0f1bd09438 |
| ToxValDB Alaska DEC | RfD | =1.43 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445781:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=65ddae7835f597973438b01e4d93220e |
ToxValDB Cal OEHHA REL derivations 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMCL (05) | =45.1 | mg/m3 | Human | inhalation | chronic; 15.6 years | occupational | LONG_REF=Zavalic M, Mandic Z, Turk R, Bogadi-Sare A, Plavec D and Skender LJ (1998c). Qualitative color vision impairment in toluene-exposed workers. Int Arch Occup Environ Health 71:194-200; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/media/downloads/crnr/toluenerel082020.pdf; YEAR=2019/2020; ORIGINAL_YEAR=2019/2020; TOXICOLOGICAL_EFFECT=Acquired color vision impairment; STUDY_GROUP=Cal OEHHA REL derivations:15951802:M:-adult workers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_52d088f3b0c354490eaffc18fef21c0d |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =150 | mg/m3 | Human | inhalation | acute; 6 hours | clinical | LONG_REF=Andersen I, Lundqvist GR, Molhave L, Pedersen OF, Proctor DF, Vaeth M and Wyon DP (1983). Human response to controlled levels of toluene in six-hour exposures. Scand J Work Environ Health 9(5): 405-18.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/media/downloads/crnr/toluenerel082020.pdf; YEAR=2019/2020; ORIGINAL_YEAR=2019/2020; TOXICOLOGICAL_EFFECT=Impaired reaction time and symptoms of headache, dizziness, feeling of intoxication, sensory irritation (eye and nose irritation); STUDY_GROUP=Cal OEHHA REL derivations:15951798:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fdf10fb9544a7b08bea6e75f1d27d97b |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =132 | mg/m3 | Human | inhalation | chronic; 15.6 years | occupational | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/media/downloads/crnr/toluenerel082020.pdf; YEAR=2019/2020; ORIGINAL_YEAR=2019/2020; TOXICOLOGICAL_EFFECT=Acquired color vision impairment; STUDY_GROUP=Cal OEHHA REL derivations:15951800:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_583331e3e79cd1f10cfd76effe0d4c24 |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =150.743 | mg/m3 | Human | inhalation | acute; 6 hours | clinical | LONG_REF=Andersen MD, Lundqvist GR, Molhave L, Pedersen OF, Proctor DF, Vaeth M, et al. Human response to controlled levels of toluene in six-hour exposures. Scand J Work Environ Health 1983;9:405-418.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=impaired reaction time and symptoms of headache, dizziness, a feeling of intoxication and slight eye and nose irritation; STUDY_GROUP=Cal OEHHA REL derivations:15951983:M:-young, healthy; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4a7a54271fb0a52b95e177af237a2a00 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =52759.9 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15520408:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_39fccd61d49e448f4bef67bfc26df338 |
ToxValDB DOE Wildlife Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =260 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511716_15511717:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f8c58a5d4ea45b4a1cbf1fbb13508bc |
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =26 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511716_15511717:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d784eeadd73d62aa2bcc214283aeb2a |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =1000 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin; STUDY_GROUP=ECOTOX:15599393:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=149f25836a23186b7480603342f1b12f |
| ToxValDB ECOTOX | NOEL | =3000 | mg/kg bw/day | Mouse | oral | short-term (developmental); 8 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight|Growth: Weight gain|Mortality: Survival|Reproduction: Progeny counts/numbers|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15611819:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=03cf67736aca9fb79e7057a5b947c814 |
ToxValDB EPA TSCA 8e 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =7537.13 | mg/m3 | Rat | inhalation | chronic; 26 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010761_108883_0DFE91BA04D2800785256930004F20C9.pdf; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=central nervous system depression, dry tales, staining of the anogenital fur; STUDY_GROUP=EPA TSCA 8e:15957695:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f15f6f9ddd7ae4369d251186564868b0 |
| ToxValDB EPA TSCA 8e | LEL | =5652.85 | mg/m3 | Rat | inhalation | chronic; 26 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010761_108883_0DFE91BA04D2800785256930004F20C9.pdf; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=increased mean body weight; STUDY_GROUP=EPA TSCA 8e:15957696:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a146edb5db95ea89d9a542486357417a |
| ToxValDB EPA TSCA 8e | LEL | =376.857 | mg/m3 | Rat | inhalation | chronic; 26 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010761_108883_0DFE91BA04D2800785256930004F20C9.pdf; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=increased serum glutamic pyruvic transaminase (SGPT); STUDY_GROUP=EPA TSCA 8e_dup_-_15957697_15957698:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4b5ba385901d767fc3364ae07947fbb6 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | LOAEL | ~226.114 | mg/m3 | Human | inhalation | acute; 8 hours | clinical | LONG_REF=Echeverria, D., Fine, L., Glangolf, G., Schork, A. and Sampaio, C. (1989). Acute neurobehavioural effects of toluene. Br. J. Ind. Med. 46 , 483-495. Foo, S. C., Jeyaratnam, J. and Koh, D. (1990). Chronic neurobehavioural effects of toluene, Br. J. Ind. Med. 47 , 480. Orbaek, P. and Nise, G. (1989). Neurashenic complaints and psychometric function of toluene-exposed rotogravure printers. Am. J. Ind. Med. 16, 67-77; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d39a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/017_toluene_oel_en.pdf; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=subjective effects; STUDY_GROUP=EU SCOEL:15952557:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f836b1fa0ff16d90e00770016a2312c7 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =192 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635280_15635281:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b941efd6111d288c39065387f156d8b |
ToxValDB Health Canada 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Health Canada | TDI | =0.22 | mg/kg bw/day | Human | oral | subchronic; 13 weeks | Toxicity Value | LONG_REF=PSL: HC, 1996a, (based on NTP, 1990a); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=increased relative liver and kidney weight neurotoxic, irritation of the respiratory tract; STUDY_GROUP=Health Canada:15637484:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_88820a90a928f116a790b82f97f33d34 |
ToxValDB IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | BMD | =431 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP (National Toxicology Program). (1990) Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B5C3F1 mice (inhalation studies). Public Health Service, U.S. Department of Health and Human Services; NTP TR 371. Available from: National Institute of Environmental Health Sciences, Research Triangle Park, NC.; TITLE=Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B5C3F1 mice (inhalation studies); AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a503a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; TOXICOLOGICAL_EFFECT=increased kidney weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15645054_15645056:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b199a97d4704b3ead3d04af289f11d39 |
| ToxValDB IRIS | BMDL | =238 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP (National Toxicology Program). (1990) Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B5C3F1 mice (inhalation studies). Public Health Service, U.S. Department of Health and Human Services; NTP TR 371. Available from: National Institute of Environmental Health Sciences, Research Triangle Park, NC.; TITLE=Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B5C3F1 mice (inhalation studies); AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a503a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; TOXICOLOGICAL_EFFECT=increased kidney weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15645054_15645056:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5c4938b1c93c39ab2708082643f20250 |
| ToxValDB IRIS | NOAEL | =128 | mg/m3 | Human | inhalation | chronic | epidemiologic | LONG_REF=Abbate, C; Giorgianni, C; Munao, F; et al. (1993) Neurotoxicity induced by exposure to toluene: an electrophysiologic study. Int Arch Occup Environ Health 64:389-392. ; Boey, KW; Foo, SC; Jeyaratnam, J. (1997) Effects of occupational exposure to toluene: a neuropsychological study on workers in Singapore. Ann Acad Med Singapore 26:84-7. ; Cavalleri, A; Gobba, F; Nicali, E; et al. (2000) Dose-related color vision impairment in toluene-exposed workers. Arch Env Health 55:399-404. ; Eller, N., B. Netterstrom and P. Laursen. (1999) Risk of chronic effects on the central nervous system at low toluene exposure. Occup. Med. 49(6): 389-395. ; Foo, SC; Jeyaratnam, J; D. Koh, D. (1990) Chronic neurobehavioral effects of toluene. Br J Ind Med 47:480-484. ; Murata, K; Araki, S; Yokoyama, K; et al. (1993) Cardiac autonomic dysfunction in rotogravure printers exposed to toluene in relation to peripheral nerve conduction. Ind Health 31:79-90. ; Nakatsuka, H; Watanabe, T; Takeuchi, Y; et al. (1992) Absence of blue-yellow color vision loss among workers exposed to toluene or tetrachloroethylene, mostly at levels below exposure limits. Int Arch Occup Environ Health 64:113-117. ; Neubert, D; Gericke, C; Hanke, B; et al. (2001) Multicenter field trial on possible health effects of toluene. II. Cross-sectional evaluation of acute low-level exposure. Toxicology 168:139-183. ; Vrca, A; Bozicevic, D; Karacic, V; et al. (1995) Visual evoked potentials in individuals exposed to long-term low concentrations of toluene. Arch Toxicol 69:337-40. ; Zavalic, M; Mandic, Z; Turk, R; et al. (1998) Quantitative assessment of color vision impairment in workers exposed to toluene. Am J Ind Med 33:297-304.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a503a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; TOXICOLOGICAL_EFFECT=neurological effects in occupationally-exposed workers; STUDY_GROUP=IRIS_dup_IRIS Summary_15645486_15645487_15645488:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0df39c37a8450a72087c11fffb3e887a |
| ToxValDB IRIS | NOAEL (ADJ) | =46 | mg/m3 | Human | inhalation | chronic | epidemiologic | LONG_REF=Abbate, C; Giorgianni, C; Munao, F; et al. (1993) Neurotoxicity induced by exposure to toluene: an electrophysiologic study. Int Arch Occup Environ Health 64:389-392. ; Boey, KW; Foo, SC; Jeyaratnam, J. (1997) Effects of occupational exposure to toluene: a neuropsychological study on workers in Singapore. Ann Acad Med Singapore 26:84-7. ; Cavalleri, A; Gobba, F; Nicali, E; et al. (2000) Dose-related color vision impairment in toluene-exposed workers. Arch Env Health 55:399-404. ; Eller, N., B. Netterstrom and P. Laursen. (1999) Risk of chronic effects on the central nervous system at low toluene exposure. Occup. Med. 49(6): 389-395. ; Foo, SC; Jeyaratnam, J; D. Koh, D. (1990) Chronic neurobehavioral effects of toluene. Br J Ind Med 47:480-484. ; Murata, K; Araki, S; Yokoyama, K; et al. (1993) Cardiac autonomic dysfunction in rotogravure printers exposed to toluene in relation to peripheral nerve conduction. Ind Health 31:79-90. ; Nakatsuka, H; Watanabe, T; Takeuchi, Y; et al. (1992) Absence of blue-yellow color vision loss among workers exposed to toluene or tetrachloroethylene, mostly at levels below exposure limits. Int Arch Occup Environ Health 64:113-117. ; Neubert, D; Gericke, C; Hanke, B; et al. (2001) Multicenter field trial on possible health effects of toluene. II. Cross-sectional evaluation of acute low-level exposure. Toxicology 168:139-183. ; Vrca, A; Bozicevic, D; Karacic, V; et al. (1995) Visual evoked potentials in individuals exposed to long-term low concentrations of toluene. Arch Toxicol 69:337-40. ; Zavalic, M; Mandic, Z; Turk, R; et al. (1998) Quantitative assessment of color vision impairment in workers exposed to toluene. Am J Ind Med 33:297-304.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a503a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=118; TOXICOLOGICAL_EFFECT=neurological effects in occupationally-exposed workers; STUDY_GROUP=IRIS_dup_IRIS Summary_15645486_15645487_15645488:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f2734b03960905b6cb122e097f0c459e |
ToxValDB NIOSH IDLH 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB NIOSH IDLH | LEL | =1130.57 | mg/m3 | Human | inhalation | acute; 20 minutes | occupational | LONG_REF=Gamberale F, Hultengren M [1972]. Toluene exposure. II. Psychophysiological functions. Scand J Work Environ Health 9:131-139.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d729b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/108883.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=significant increases in reaction times; STUDY_GROUP=NIOSH IDLH_dup_-_15953781_15953782:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ba4f3ac7d34da137be43fdfde7de68b4 |
| ToxValDB NIOSH IDLH | LEL | =2638 | mg/m3 | Human | inhalation | acute; 20 minutes | occupational | LONG_REF=Gamberale F, Hultengren M [1972]. Toluene exposure. II. Psychophysiological functions. Scand J Work Environ Health 9:131-139.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d729b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/108883.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=significant decrease in perceptual speed; STUDY_GROUP=NIOSH IDLH_dup_-_15953781_15953782:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c51386e2f5f2129ac0b53059df015fd |
| ToxValDB NIOSH IDLH | LEL | =2261.14 | mg/m3 | Human | inhalation | acute; 3 hours | occupational | LONG_REF=von Oettingen WF, Neal PA, Donahue DD [1942]. The toxicity and potential dangers of toluene: preliminary report. JAMA 118:579-584.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d729b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/108883.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=extreme fatigue, mental confusion, exhilaration, nausea, headache and dizziness; STUDY_GROUP=NIOSH IDLH:15953783:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_546369d95d4288e45f5e66cc0bc2d990 |
| ToxValDB NIOSH IDLH | LEL | >1884.28 | mg/m3 | Human | inhalation | acute; 3 hours | occupational | LONG_REF=Wilson RH [1943]. Toluene poisoning. JAMA 123:1106-1108.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d729b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/108883.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=dangerous and will cause symptoms attributable to depression of the central nervous system and the bone marrow; STUDY_GROUP=NIOSH IDLH:15953786:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2bf8e36190c81096e944d4220f7114ec |
| ToxValDB NIOSH IDLH | NEL | =753.713 | mg/m3 | Human | inhalation | acute; 8 hours | occupational | LONG_REF=Wilson RH [1943]. Toluene poisoning. JAMA 123:1106-1108.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d729b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/108883.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=some workers will tolerate with no demonstrable ill effects; STUDY_GROUP=NIOSH IDLH_dup_-_15953784_15953785:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03f871c802bd7bae51abc934cf5afe0a |
ToxValDB TX TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | NOAEL | =120.594 | mg/m3 | Human | inhalation | chronic; 10 years | occupational | LONG_REF=Zavalic, M, Z Mandic, R Turk, et al. 1998. Quantitative assessment of color vision impairment in workers exposed to toluene. Am J Ind Med 33:297-304.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5abc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/toluene.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Color vision impairment; STUDY_GROUP=TX TCEQ:15954697:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d071d75f36c41eb896a5e5de4ab204a |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 3FPU23BG52 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3FPU23BG52"} |
| openFDA substances | FDA UNII substance identifier | 3FPU23BG52 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3FPU23BG52"} |
| openFDA substances | FDA UNII substance identifier | 3FPU23BG52 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3FPU23BG52"} |
| openFDA substances | FDA UNII substance identifier | 3FPU23BG52 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3FPU23BG52"} |