NOAEL Studies Cosmetic Ingredient

Tricaprylin NOAEL Studies

INCI: TRICAPRYLIN (GLYCEROL TRIOCTANOATE)

CAS: 538-23-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =34200 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7307; row=10033; data_type=In Vivo; mixture=Chemical; chemical_name=Tricaprylin; preferred_name=Tricaprylin; dtxsid=DTXSID6021375; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021375; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021375; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =33300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_7305; row=10034; data_type=In Vivo; mixture=Chemical; chemical_name=Tricaprylin; preferred_name=Tricaprylin; dtxsid=DTXSID6021375; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021375; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021375; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =4770 mg/kg bw/day Rat oral subchronic; 31 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c153c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22516/7/6/2?documentUUID=f60b3c52-261a-48ea-a7c1-d3d2b3add0b2; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832978_15832979:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cbd450d5de32ae46a4981470002c99c6
ToxValDB_ECHA_IUCLID LOAEL =9540 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c155c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22516/7/6/2?documentUUID=f60b3c52-261a-48ea-a7c1-d3d2b3add0b2; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844971_15844972:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f80ba546b8d958d61a3e29459a5a3c4
ToxValDB_ECHA_IUCLID NOAEL =1908 mg/kg bw/day Rat oral subchronic; 31 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c153c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22516/7/6/2?documentUUID=f60b3c52-261a-48ea-a7c1-d3d2b3add0b2; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832978_15832979:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_820e382a82fa667013d19e2f018ededb
ToxValDB_ECHA_IUCLID NOAEL =4770 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c155c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22516/7/6/2?documentUUID=f60b3c52-261a-48ea-a7c1-d3d2b3add0b2; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844971_15844972:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8919713bf945037e92d89a519ffd7bcf
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6P92858988 UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H50O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6P92858988"}
openFDA substances FDA UNII substance identifier 6P92858988 UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H50O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6P92858988"}
openFDA substances FDA UNII substance identifier 6P92858988 UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H50O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6P92858988"}
openFDA substances FDA UNII substance identifier 6P92858988 UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H50O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6P92858988"}