NOAEL Studies
Cosmetic Ingredient
Triclosan NOAEL Studies
INCI: TRICLOSAN
CAS: 3380-34-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 38 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=63b840c8-eea4-4155-b862-e6d361e3dcb3_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=63b840c8-eea4-4155-b862-e6d361e3dcb3/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-05-06; basis=other:; key_result=false; entry_uuid=14466b00-b4c4-477d-94d8-06bbc500cc38 |
| ECHA | LOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=00b7c7b5-0353-4cc1-a5d0-9ca88f9b3bf4_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=00b7c7b5-0353-4cc1-a5d0-9ca88f9b3bf4/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-04-16; basis=other:; key_result=false; entry_uuid=1546d9fc-be40-4a01-ba29-d387ba7d4ee0 |
| ECHA | LOAEL | 200 | mg/kg bw/day | hamster, Syrian | oral: feed | - | sub-chronic toxicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=7a0bf00c-ba6e-4ef5-aa03-d507569926e6_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=7a0bf00c-ba6e-4ef5-aa03-d507569926e6/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-10-27; basis=other:; key_result=false; entry_uuid=c383d247-2882-41c1-ab83-103aba4b32e1 |
| ECHA | LOAEL | 30 | mg/kg bw/day | mouse | oral: feed | - | carcinogenicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=0e82b8da-3ddf-4446-88f7-5f600cf34b58_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=0e82b8da-3ddf-4446-88f7-5f600cf34b58/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1995; ReportDate=1995-11-22; basis=other:; key_result=false; entry_uuid=d172c83b-579e-4d10-bd5d-02ad6de9a102 |
| ECHA | LOAEL | 250 | mg/kg bw/day | hamster, Syrian | oral: feed | - | chronic toxicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=4320f3e5-1122-4956-aaf2-6265036dc943_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=4320f3e5-1122-4956-aaf2-6265036dc943/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1999; ReportDate=1999-03-30; basis=other:; key_result=false; entry_uuid=11be10be-5c55-49ce-89d9-7c03609628db |
| ECHA | LOAEL | 25 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=c1a460a5-496b-4472-abcc-deb0bc82af67_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=c1a460a5-496b-4472-abcc-deb0bc82af67/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1993-01-28; basis=other:; key_result=false; entry_uuid=47a681b3-892a-4468-bfa1-2b018eb183f9 |
| ECHA | LOAEL | 10 | mg/kg bw/day | mouse | oral: feed | - | chronic toxicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=88697153-5e30-4c27-9e19-a1d0a9c44e47_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=88697153-5e30-4c27-9e19-a1d0a9c44e47/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=a31573fe-179e-460a-aa7c-e3c6f0f99c2e |
| ECHA | NOAEL | 50 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=58ada8e1-1f19-4103-95b6-63f522b4bb5f_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=58ada8e1-1f19-4103-95b6-63f522b4bb5f/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-05-06; basis=other:; key_result=false; entry_uuid=2a58af86-d6cf-436d-b354-48beebcb5e93 |
| ECHA | NOAEL | 75 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=58ada8e1-1f19-4103-95b6-63f522b4bb5f_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=58ada8e1-1f19-4103-95b6-63f522b4bb5f/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-05-06; basis=other:; key_result=false; entry_uuid=d47701f3-061b-4445-ab06-a2388942895c |
| ECHA | NOAEL | 80 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=cf3b5fba-0f20-4b30-afd0-b2fc1ae1ba90_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=cf3b5fba-0f20-4b30-afd0-b2fc1ae1ba90/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-14; basis=other:; key_result=false; entry_uuid=531b621f-c26d-4ded-a564-8bd7212a4342 |
| ECHA | NOAEL | 25 | mg/kg bw/day | dog | oral: feed | - | sub-chronic toxicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=2aa6a799-1eca-4741-8b86-16063177a7d2_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=2aa6a799-1eca-4741-8b86-16063177a7d2/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1970; ReportDate=1970-07-10; basis=other:; key_result=false; entry_uuid=68490924-4ec0-49a0-bfe8-a43c89500dd9 |
| ECHA | NOAEL | 250 | mg/kg bw/day | hamster, Syrian | oral: feed | - | carcinogenicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=bde4cf7d-6c60-40d3-94ad-1dea2255b86f_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=bde4cf7d-6c60-40d3-94ad-1dea2255b86f/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1999; ReportDate=1999-03-30; basis=other:; key_result=false; entry_uuid=5528895e-3604-4ecb-970c-06be77b051bd |
| ECHA | NOAEL | 3 | mg/kg bw/day | primate | oral: gavage | - | repeated dose toxicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=411b0218-5f9b-4314-9de1-67367285448e_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=411b0218-5f9b-4314-9de1-67367285448e/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1969; ReportDate=1969-04-17; key_result=false; entry_uuid=865420a7-26df-4416-85f5-f11ecebfd344 |
| ECHA | NOAEL | 100 | mg/kg bw/day | primate | oral: gavage | - | repeated dose toxicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=411b0218-5f9b-4314-9de1-67367285448e_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=411b0218-5f9b-4314-9de1-67367285448e/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1969; ReportDate=1969-04-17; key_result=false; entry_uuid=e79364bc-cd82-4ae9-8046-b6768f7780ce |
| ECHA | NOEL | 100 | mg/kg bw/day | rat | oral: unspecified | - | neurotoxicity: short-term oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=b2dd418a-e600-460e-bb2c-4382b89834ad_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=b2dd418a-e600-460e-bb2c-4382b89834ad/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-10-02; basis=other:; key_result=false; entry_uuid=79d3f42f-70a2-488f-b658-00f419863ace |
| ECHA | NOEL | 10 | mg/kg bw/day | mouse | oral: feed | - | carcinogenicity: oral | dossier=6a134daa-c07d-46e5-97d5-80457194aceb.i6z; document=0e82b8da-3ddf-4446-88f7-5f600cf34b58_6a134daa-c07d-46e5-97d5-80457194aceb.i6d; document_key=0e82b8da-3ddf-4446-88f7-5f600cf34b58/6a134daa-c07d-46e5-97d5-80457194aceb; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1995; ReportDate=1995-11-22; key_result=false; entry_uuid=d5021107-a039-42ff-90bf-8fbb4fcd00a4 |
| ECHA | LOAEL | =30 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c75; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/8?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816235_15816236:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f59f6d79d88e212dbb72d507fc11c8dd |
| ECHA | LOAEL | =288 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c798a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830847_15830848:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db814aab14e47ef056bba0e2f56f8aee |
| ECHA | LOAEL | =200 | mg/kg bw/day | Hamster | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb15e4b0a7c65d224cca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837696_15837697:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cdc15302f6a82656d983a5b113cdaa4d |
| ECHA | LOAEL | =1000 | ppm | Mouse | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1fe4b0a7c65d1c79a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838305_15838306:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f73a8101f9f08a43665b88a74c1dc619 |
| ECHA | LOAEL | =25 | mg/kg bw/day | Mouse | oral | subchronic; 45 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1fe4b0a7c65d1c79ba; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15842497:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b15df65cca0ab9ad8fdb78572eddc1a6 |
| ECHA | NOAEL | =234 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/8?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15816174:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_555305798cc168d18d9f7289b7382e12 |
| ECHA | NOAEL | =250 | mg/kg bw/day | Hamster | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216dba; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/8?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15818860:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cbcbcb2fc34ae9cfcaa7c8344eb7ceb5 |
| ECHA | NOAEL | =150 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/9/3?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820575_15821120:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f06ca839f46a6d57ab82eea65c8014e6 |
| ECHA | NOAEL | =25 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/9/3?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820749_15820810:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_186327e83fbc2d78eae721a2d1935972 |
| ECHA | NOAEL | =75 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/9/3?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821071_15821105:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2ee6b75589072348460cf1905e3ae8e |
| ECHA | NOAEL | =50 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/9/3?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15822391:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_67ece05ff93225ad0eb26a660551eec3 |
| ECHA | NOAEL | =80 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | GUIDELINE=EPA OPP 82-3 (Subchronic Dermal Toxicity 90 Days); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f1ae4b096bca877c5ac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/4?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15826749:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1cbb7f66bc5d29b92571110215f2723b |
| ECHA | NOAEL | =96 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c798a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830847_15830848:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0298de9e9db7b80f8abed5a902cdb659 |
| ECHA | NOAEL | =3 | mg/kg bw/day | Primate | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb15e4b0a7c65d224cbb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834034_15834035:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6e8401f71c5a1c27224dd52955441d4b |
| ECHA | NOAEL | =100 | mg/kg bw/day | Primate | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb15e4b0a7c65d224cbb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834034_15834035:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1a137699e5aaec38ede50511398e568 |
| ECHA | NOAEL | =78 | mg/kg bw/day | Rat | oral | chronic; 52 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c799e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837430_15837431:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d556e354e053ede603a05166ed2333d1 |
| ECHA | NOAEL | =50 | ppm | Mouse | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1fe4b0a7c65d1c79a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838305_15838306:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc2104922a0ef63adb7eb082cb1801ad |
| ECHA | NOAEL | =58.5 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1fe4b0a7c65d1c79ac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/6/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15839295:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_af2e7be641186efcac6e8c2e0b74fa77 |
| ECHA | NOAEL | =3000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21ad6e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/9/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15855392:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c50adb76adb9b3928e667aabdec083d9 |
| ECHA | NOAEL | =1000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21ad6e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/9/2?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15859363:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d09a09c61ada70eb3aa9748c89f62b5d |
| ECHA | NOEL | =10 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c75; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/8?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816235_15816236:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db8dc4a6ea37c0fa92ca7eacc73685f4 |
| ECHA | NOEL | =100 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4f10; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12675/7/10/1?documentUUID=6a134daa-c07d-46e5-97d5-80457194aceb; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15825869:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_23d9317c68c488af294831c8797faab7 |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =3700 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_5721; row=9122; data_type=In Vivo; mixture=Chemical; chemical_name=Triclosan; preferred_name=Triclosan; dtxsid=DTXSID5032498; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5032498; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 34.66 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=2120; Record_ID=adme_parameters_238; Data_Type=Measured; DTXSID=DTXSID5032498; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=34.66; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5032498 |
| NTP ICE adme parameters | Clint | 27.8 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2121; Record_ID=adme_parameters_238; Data_Type=Measured; DTXSID=DTXSID5032498; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=27.8; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5032498 |
| NTP ICE adme parameters | Fu | 0 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=2118; Record_ID=adme_parameters_238; Data_Type=Measured; DTXSID=DTXSID5032498; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5032498 |
| NTP ICE adme parameters | Fu | 0.00428 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2119; Record_ID=adme_parameters_238; Data_Type=Measured; DTXSID=DTXSID5032498; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.00428; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5032498 |
NTP ICE dart 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 150 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=87710; Record_ID=dart_38249; Data_Type=In Vivo; DTXSID=DTXSID5032498; Assay=DART, In life observation; Endpoint=LOEL; Response=150; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 2730; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5032498 |
NTP ICE endocrine 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 14.101785855879 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15772; RecordID=ARPathway2016_156; DatasetName=ARPathway2016; DTXSID=DTXSID5032498; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=14.101785855879; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | AC50/EC50/IC50 | 1000 | fold excess | - | - | - | In Vitro; AR Binding | sheet=Data_invitro; excel_row=53; Record_ID=endocrine_invitro_47; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1000; Reported_Response_Unit=fold excess; Response=1000; Response_Unit=fold excess; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Gee et al. 2008; 17992702; 10.1002/jat.1316; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | AC50/EC50/IC50 | 1470 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13158; Record_ID=endocrine_invitro_4078; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1470; Reported_Response_Unit=nM; Response=1470; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Rostkowski et al. 2011; 22047186; 10.1021/es202966c; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | AC50/EC50/IC50 | 930 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13159; Record_ID=endocrine_invitro_4079; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=930; Reported_Response_Unit=nM; Response=930; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Indiveri et al. 2014; 24972338; 10.1016/j.reprotox.2014.06.004; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | AC50/EC50/IC50 | 5130 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13424; Record_ID=endocrine_invitro_4143; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=5130; Reported_Response_Unit=nM; Response=5130; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | AC50/EC50/IC50 | 7500 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13426; Record_ID=endocrine_invitro_4144; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=7500; Reported_Response_Unit=nM; Response=7500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | ACC | 11.2660068327607 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15773; RecordID=ARPathway2016_156; DatasetName=ARPathway2016; DTXSID=DTXSID5032498; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=11.2660068327607; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | IC25 | <10000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13049; Record_ID=endocrine_invitro_4042; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=IC25; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=10000; Reported_Response_Unit=IC25 (nM); Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | LEL | 1 | nM | - | - | - | In Vitro; AR Transactivation-Agonist | sheet=Data_invitro; excel_row=10798; Record_ID=endocrine_invitro_3635; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1; Reported_Response_Unit=nM; Response=1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Christen et al. 2010; 20943248; 10.1016/j.chemosphere.2010.09.031; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | LEL | 100 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=14874; Record_ID=endocrine_invitro_4229; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=100; Reported_Response_Unit=nM; Response=100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Gee et al. 2008; 17992702; 10.1002/jat.1316; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | LEL | 1000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=14876; Record_ID=endocrine_invitro_4230; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1000; Reported_Response_Unit=nM; Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2007; 17481686; 10.1016/j.taap.2007.03.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | LOEL | 7.5 | mg/kg bw/day | Rat | Oral | Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=812; Record_ID=endocrine_invivo_111; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=187.5; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Jung et al. 2012; 22062131; 10.1016/j.toxlet.2011.10.017|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | Model Score | 0.273 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15774; RecordID=ARPathway2016_156; DatasetName=ARPathway2016; DTXSID=DTXSID5032498; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.273; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | Model Score | 0.0389 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15775; RecordID=ARPathway2016_156; DatasetName=ARPathway2016; DTXSID=DTXSID5032498; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.0389; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15778; RecordID=ERPathway2016_592; DatasetName=ERPathway2016; DTXSID=DTXSID5032498; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | Relative potency | 91 | % | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=15174; Record_ID=endocrine_invitro_4079; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=91; Reported_Response_Unit=%; Response=91; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Indiveri et al. 2014; 24972338; 10.1016/j.reprotox.2014.06.004; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | Relative potency | 40 | % | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=15175; Record_ID=endocrine_invitro_4228; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=40; Reported_Response_Unit=%; Response=40; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE endocrine | Uterine weight increase vs control | 220 | % | Rat | Oral | Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=500; Record_ID=endocrine_invivo_111; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=220; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=187.5; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
NTP ICE skin sensitization 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6811; Record_ID=skin_sensitization_invivo_1559; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE skin sensitization | Induction dose per skin area | 13950 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6817; Record_ID=skin_sensitization_invivo_1561; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=13950; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE skin sensitization | Induction dose per skin area | 697.5 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6847; Record_ID=skin_sensitization_invivo_1566; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=697.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE skin sensitization | Induction dose per skin area | 3488 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6856; Record_ID=skin_sensitization_invivo_1568; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3488; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6815; Record_ID=skin_sensitization_invivo_1559; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5032498; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032498 |
SCCS Opinion 83 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.3 | % | human | - | - | NOAEL study | p.119 |
| SCCS Opinion | NOAEL | =1 | - | - | - | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =1.59 | % | rat | oral | - | NOAEL study | p.65 |
| SCCS Opinion | NOAEL | =2 | - | rat | - | - | reproductive toxicity | p.59 |
| SCCS Opinion | NOAEL | =3 | mg/kg bw/day | rabbit | oral | Subchronic | repeated dose toxicity | p.27 |
| SCCS Opinion | NOAEL | =3 | mg/kg bw/d | rabbit | - | 91 days | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =3 | - | - | - | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =3.3 | - | rat | oral | Developmental | developmental toxicity | p.61 |
| SCCS Opinion | NOAEL | =4 | % | - | dermal | Sub-Chronic | repeated dose toxicity | p.31 |
| SCCS Opinion | NOAEL | =5.1 | % | rabbit | oral | 1992d | NOAEL study | p.63 |
| SCCS Opinion | NOAEL | =8 | mg/kg bw | rat | oral | - | reproductive toxicity | p.65 |
| SCCS Opinion | NOAEL | =9 | - | - | - | - | NOAEL study | p.59 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/d | rat | oral | 104-week | carcinogenicity | p.33 |
| SCCS Opinion | NOAEL | =10 | - | - | dermal | - | repeated dose toxicity | p.22 |
| SCCS Opinion | NOAEL | =11 | - | - | - | - | NOAEL study | p.23 |
| SCCS Opinion | NOAEL | =12 | mg/kg bw/day | rat | dermal | - | irritation | p.21 |
| SCCS Opinion | NOAEL | =12 | mg/kg bw | rat | inhalation | 21 days | repeated dose toxicity | p.22 |
| SCCS Opinion | NOAEL | =12 | mg/kg bw/d | rat | oral | 13 weeks | carcinogenicity | p.33 |
| SCCS Opinion | NOAEL | =12 | mg/kg/d | human | - | - | NOAEL study | p.122 |
| SCCS Opinion | NOAEL | =13 | - | - | oral | Sub-Chronic | repeated dose toxicity | p.29 |
| SCCS Opinion | NOAEL | =16 | - | - | - | - | carcinogenicity | p.56 |
| SCCS Opinion | NOAEL | =17 | - | mouse | - | - | NOAEL study | p.59 |
| SCCS Opinion | NOAEL | =19 | - | - | - | Developmental | developmental toxicity | p.61 |
| SCCS Opinion | NOAEL | =20 | - | - | - | developmental | developmental toxicity | p.65 |
| SCCS Opinion | NOAEL | =21 | - | mouse | - | developmental | repeated dose toxicity | p.68 |
| SCCS Opinion | NOAEL | =24 | mg/kg | rat | dermal | - | irritation | p.21 |
| SCCS Opinion | NOAEL | =24 | mg/kg bw | mouse | dermal | 14 days | irritation | p.22 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/day | dog | oral | Subchronic | repeated dose toxicity | p.27 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/d | dog | - | - | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =25 | mg/kg | rat | oral | - | developmental toxicity | p.63 |
| SCCS Opinion | NOAEL | =25 | - | mouse | oral | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =30 | mg/kg bw/d | - | - | 52 weeks | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =30 | mg/kg | rat | - | - | carcinogenicity | p.58 |
| SCCS Opinion | NOAEL | =30 | mg/kg/day | human | oral | chronic | NOAEL study | p.122 |
| SCCS Opinion | NOAEL | =30 | mg/kg/d | human | - | - | NOAEL study | p.122 |
| SCCS Opinion | NOAEL | =38 | % | - | oral | 52- week | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =40 | % | - | - | - | NOAEL study | p.58 |
| SCCS Opinion | NOAEL | =48 | mg/kg/d | rat | oral | 13 weeks | carcinogenicity | p.33 |
| SCCS Opinion | NOAEL | =48 | mg/kg bw/d | rat | oral | 95-week | repeated dose toxicity | p.34 |
| SCCS Opinion | NOAEL | =50 | ppm | rat | oral | 14-day | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/d | rat | oral | - | NOAEL study | p.62 |
| SCCS Opinion | NOAEL | =50 | mg/kg | rat | oral | - | developmental toxicity | p.64 |
| SCCS Opinion | NOAEL | =50 | - | rabbit | oral | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =60 | mg/kg bw/d | rat | dermal | - | irritation | p.21 |
| SCCS Opinion | NOAEL | =63 | - | - | - | - | NOAEL study | p.63 |
| SCCS Opinion | NOAEL | =65 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.60 |
| SCCS Opinion | NOAEL | =65 | mg/kg | rat | oral | Developmental | developmental toxicity | p.61 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/day | rat | oral | Subchronic | repeated dose toxicity | p.24 |
| SCCS Opinion | NOAEL | =75 | mg/kg | - | - | - | NOAEL study | p.25 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/d | rat | oral | 90 days | NOAEL study | p.26 |
| SCCS Opinion | NOAEL | =80 | mg/kg/day | rat | dermal | Sub-Chronic | repeated dose toxicity | p.31 |
| SCCS Opinion | NOAEL | =80 | mg/kg bw/d | rat | dermal | 28-day | NOAEL study | p.31 |
| SCCS Opinion | NOAEL | =82 | % | rat | oral | 10 weeks | NOAEL study | p.60 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/d | - | oral | 90 days | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =100 | mg/kg | rat | oral | - | developmental toxicity | p.64 |
| SCCS Opinion | NOAEL | =100 | - | rat | oral | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | - | - | - | NOAEL study | p.106 |
| SCCS Opinion | NOAEL | =150 | mg/kg bw/d | rabbit | oral | 90 days | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =150 | mg/kg | rabbit | oral | 1992d | developmental toxicity | p.64 |
| SCCS Opinion | NOAEL | =160 | mg/kg bw/day | mouse | oral | - | NOAEL study | p.61 |
| SCCS Opinion | NOAEL | =169 | mg/kg | mouse | oral | 28 days | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/d | - | - | - | NOAEL study | p.25 |
| SCCS Opinion | NOAEL | =200 | mg/kg | rat | - | - | reproductive toxicity | p.67 |
| SCCS Opinion | NOAEL | =229 | mg/kg bw/d | rat | oral | 10 weeks | NOAEL study | p.60 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/d | - | oral | 52- week | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/d | - | - | 4 weeks | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =300 | mg/kg | rat | oral | Developmental | developmental toxicity | p.61 |
| SCCS Opinion | NOAEL | =300 | - | rabbit | oral | 91-Day | genotoxicity | p.125 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | rat | oral | - | NOAEL study | p.60 |
| SCCS Opinion | NOAEL | =350 | mg/kg | rat | - | developmental | reproductive toxicity | p.121 |
| SCCS Opinion | NOAEL | =381 | - | - | - | - | NOAEL study | p.119 |
| SCCS Opinion | NOAEL | =422 | mg/kg bw/d | rat | - | 52 weeks | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =513 | - | - | - | - | NOAEL study | p.119 |
| SCCS Opinion | NOAEL | =750 | mg/kg bw/d | - | oral | 13 weeks | NOAEL study | p.27 |
| SCCS Opinion | NOAEL | =900 | mg/kg bw/d | - | oral | 13 weeks | NOAEL study | p.27 |
| SCCS Opinion | NOAEL | =988 | - | - | - | - | NOAEL study | p.59 |
| SCCS Opinion | NOAEL | =1000 | ppm | - | oral | Subchronic | repeated dose toxicity | p.25 |
| SCCS Opinion | NOAEL | =1192 | - | rat | - | - | carcinogenicity | p.59 |
| SCCS Opinion | NOAEL | =1978 | - | mouse | - | - | reproductive toxicity | p.66 |
| SCCS Opinion | NOAEL | =1987 | - | rat | - | Developmental | reproductive toxicity | p.67 |
| SCCS Opinion | NOAEL | =1992 | - | rat | - | - | NOAEL study | p.59 |
| SCCS Opinion | NOAEL | =2000 | - | mouse | - | 14 days | repeated dose toxicity | p.68 |
| SCCS Opinion | NOAEL | =3000 | ppm | rat | oral | - | reproductive toxicity | p.60 |
EPA ToxRefDB v3 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =168.78 | mg/kg bw/day | mouse | oral | 0 day to 28 day | SUB | study_id=2726; toxval_study_source_id=studyid2726_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hemosiderosis|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|organ weight-liver-absolute|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-liver-hypertrophy|clinical chemistry-urea nitrogen-urea|organ weight-liver-relative to body weight|pathology microscopic-liver-necrosis|pathology microscopic-liver-fatty change|hematology-platelet-platelet|organ weight-liver-relative to brain weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|clinical chemistry-globulins-globulins|clinical chemistry-albumin-albumin|clinical chemistry-creatinine-creatinine|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|pathology microscopic-liver-infiltration cellular; dose_level=2; study_year=1987; study_citation=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =6.48 | mg/kg bw/day | mouse | oral | 0 day to 28 day | SUB | study_id=2726; toxval_study_source_id=studyid2726_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-infiltration cellular|clinical chemistry-albumin-globulin ratio-albumin-globulin ratio|hematology-platelet-platelet|hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-globulins-globulins|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|clinical chemistry-urea nitrogen-urea|pathology microscopic-liver-calculus|pathology microscopic-liver-necrosis|clinical chemistry-creatinine-creatinine|hematology-hematocrit (hct)-hematocrit (hct)|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|organ weight-kidney-absolute|organ weight-liver-relative to body weight|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|pathology microscopic-liver-vacuolization cytoplasmic|organ weight-liver-absolute|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-liver-hemosiderosis|pathology microscopic-liver-fatty change|organ weight-liver-relative to brain weight|pathology microscopic-liver-hypertrophy; dose_level=1; study_year=1987; study_citation=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =25 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 day to 13 week | SUB | study_id=2727; toxval_study_source_id=studyid2727_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|pathology gross-stomach-discolored|pathology gross-liver-[other]|organ weight-liver-relative to body weight|organ weight-gallbladder-relative to body weight|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-hematocrit (hct)-hematocrit (hct)|organ weight-gallbladder-absolute|pathology gross-liver-discolored|hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-liver-absolute|pathology microscopic-liver-vacuolization|pathology microscopic-liver-mineralization|pathology microscopic-liver-hypertrophy|pathology microscopic-liver-necrosis|pathology microscopic-liver-inflammation|pathology gross-liver-enlarged|pathology microscopic-liver-pigmentation|organ weight-salivary glands-absolute|organ weight-uterus-absolute|organ weight-salivary glands-relative to brain weight|organ weight-salivary glands-relative to body weight|in life observation-clinical signs-hunched posture|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-clinical signs-lethargy|organ weight-uterus-relative to brain weight|organ weight-uterus-relative to body weight|organ weight-kidney-absolute|organ weight-ovary-absolute|in life observation-body weight-body weight gain|in life observation-clinical signs-body cold to touch|in life observation-clinical signs-[other]; dose_level=1; study_year=1993; study_citation=Trutter, J. (1993) 13-Week Subchronic Oral Toxicity Study Of Triclosan In Cd-1 Mice: Lab Project Number: Hwa 483-287: 483287. Unpublished Study Prepared By Hazleton Washington, Inc. 1113 P.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =100 | mg/kg bw/day | rat (wistar; Colworth Wistar) | oral | 6 GD to 15 GD | DEV | study_id=2729; toxval_study_source_id=studyid2729_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-food consumption-food consumption|in life observation-clinical signs-[other]|in life observation-body weight-body weight gain|in life observation-clinical signs-defecation (diarrhea); dose_level=2; study_year=1992; study_citation=Denning, H.; Sliwa, S.; Willson, G. (1992) Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1. Lab Project Number: RT/3/84. Unpublished Study Prepared By Unilever Research Environmental Safety Lab. 43 P.; dsstox_substance_id=DTXSID5032498; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =50 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=2730; toxval_study_source_id=studyid2730_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions; dose_level=2; study_year=1992; study_citation=Schroeder, R. (1992) A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan). Lab Project Number: 91-3666. Unpublished Study Prepared By Bio/Dynamics, Inc. 339 P.; dsstox_substance_id=DTXSID5032498; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =150 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=2730; toxval_study_source_id=studyid2730_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=3; study_year=1992; study_citation=Schroeder, R. (1992) A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan). Lab Project Number: 91-3666. Unpublished Study Prepared By Bio/Dynamics, Inc. 339 P.; dsstox_substance_id=DTXSID5032498; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =15 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=2733; toxval_study_source_id=studyid2733_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-urea nitrogen-urea nitrogen|clinical chemistry-triglycerides-triglycerides|pathology microscopic-lung-foam cell aggregation|clinical chemistry-bilirubin-total bilirubin|pathology microscopic-kidney-calculus|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-glucose-glucose|in life observation-body weight-body weight|organ weight-liver-absolute|hematology-hematocrit (hct)-hematocrit (hct); dose_level=1; study_year=1986; study_citation=Goodman, D. (1990) Irgasan 300 Dp: Pathology Working Group Report On Triclosan/Carcinogenicity Study In Sprague-Dawley Rats: (Supplement To Mrid 00161332). Lab Project Number: 90-128. Unpublished Study Prepared By Pathco Inc. 550 P.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =135.59 | mg/kg bw/day | mouse | oral | 0 day to 28 day | SUB | study_id=2726; toxval_study_source_id=studyid2726_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|pathology microscopic-liver-necrosis|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|organ weight-liver-relative to body weight|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|pathology microscopic-liver-vacuolization cytoplasmic|organ weight-liver-absolute|pathology microscopic-liver-hemosiderosis|pathology microscopic-liver-fatty change|organ weight-liver-relative to brain weight|pathology microscopic-liver-hypertrophy; dose_level=2; study_year=1987; study_citation=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =300 | mg/kg bw/day | rat (wistar; Colworth Wistar) | oral | 6 GD to 15 GD | DEV | study_id=2729; toxval_study_source_id=studyid2729_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain|in life observation-clinical signs-defecation (diarrhea); dose_level=3; study_year=1992; study_citation=Denning, H.; Sliwa, S.; Willson, G. (1992) Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1. Lab Project Number: RT/3/84. Unpublished Study Prepared By Unilever Research Environmental Safety Lab. 43 P.; dsstox_substance_id=DTXSID5032498; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =8.25 | mg/kg bw/day | mouse | oral | 0 day to 28 day | SUB | study_id=2726; toxval_study_source_id=studyid2726_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|pathology microscopic-liver-infiltration cellular|clinical chemistry-globulins-globulins|clinical chemistry-albumin-albumin|clinical chemistry-creatinine-creatinine|hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|pathology microscopic-liver-fatty change|organ weight-liver-relative to brain weight|hematology-platelet-platelet|organ weight-liver-relative to body weight|pathology microscopic-liver-necrosis|organ weight-liver-absolute|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-liver-hypertrophy|clinical chemistry-urea nitrogen-urea|pathology microscopic-liver-hemosiderosis|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk); dose_level=1; study_year=1987; study_citation=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | mouse | oral | 0 day to 28 day | SUB | study_id=2726; toxval_study_source_id=studyid2726_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|pathology microscopic-liver-hemosiderosis|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-liver-absolute|pathology microscopic-liver-vacuolization cytoplasmic|pathology microscopic-liver-fatty change|organ weight-liver-relative to brain weight|pathology microscopic-liver-hypertrophy|hematology-platelet-platelet|pathology microscopic-liver-infiltration cellular|clinical chemistry-albumin-globulin ratio-albumin-globulin ratio|hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-urea nitrogen-urea|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|clinical chemistry-globulins-globulins|pathology microscopic-liver-calculus|pathology microscopic-liver-necrosis|clinical chemistry-creatinine-creatinine|organ weight-kidney-absolute|hematology-hematocrit (hct)-hematocrit (hct)|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt); dose_level=0; study_year=1987; study_citation=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =30 | mg/kg bw/day | rat (wistar; Colworth Wistar) | oral | 6 GD to 15 GD | DEV | study_id=2729; toxval_study_source_id=studyid2729_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-[other]|in life observation-food consumption-food consumption|in life observation-water consumption-water consumption|in life observation-body weight-body weight gain|in life observation-clinical signs-defecation (diarrhea); dose_level=1; study_year=1992; study_citation=Denning, H.; Sliwa, S.; Willson, G. (1992) Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1. Lab Project Number: RT/3/84. Unpublished Study Prepared By Unilever Research Environmental Safety Lab. 43 P.; dsstox_substance_id=DTXSID5032498; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =15 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=2730; toxval_study_source_id=studyid2730_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions; dose_level=1; study_year=1992; study_citation=Schroeder, R. (1992) A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan). Lab Project Number: 91-3666. Unpublished Study Prepared By Bio/Dynamics, Inc. 339 P.; dsstox_substance_id=DTXSID5032498; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =50 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=2732; toxval_study_source_id=studyid2732_Adult Pregnancy_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=1988; study_citation=Morseth, S. (1988) Two-Generation Reproduction Study In Rats - FAT 80'023: HLA Study No. 2386-100. Unpublished Study Prepared By Hazleton Laboratories America, Inc. 986 P.; dsstox_substance_id=DTXSID5032498; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ECOTOX 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.8 | mmol/kg-day | Rat | injection | short-term; 5 days | short-term | LONG_REF=Chemosphere34(4): 719-730 Hanioka,N., H. Jinno, T. Nishimura, and M. Ando Effect of 2,4,4\'-Trichloro-2\'-Hydroxydiphenyl Ether on Cytochrome P450 Enzymes in the Rat Liver 1997; TITLE=Effect of 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether on Cytochrome P450 Enzymes in the Rat Liver; AUTHOR=Hanioka,N., H. Jinno, T. Nishimura, and M. Ando; DOI=10.1016/s0045-6535(97)00464-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=40088; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Enzyme(s): Aniline hydroxylase|Enzyme(s): Erythromycin N-demethylase|Enzyme(s): NADPH cytochrome C reductase|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594995_15594996_15596616_15596617_15597029_15602161:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4f5a93c37a891081668a543c431cb0c8 |
| ToxValDB ECOTOX | LOEL | =25 | mg/kg bw/day | Mouse | injection | short-term; 12 days | short-term | LONG_REF=Mutat. Res.79(1): 7-12 Russell,L.B., and C.S. Montgomery Use of the Mouse Spot Test to Investigate the Mutagenic Potential of Triclosan (Irgasan DP300) 1980; TITLE=Use of the Mouse Spot Test to Investigate the Mutagenic Potential of Triclosan (Irgasan DP300); AUTHOR=Russell,L.B., and C.S. Montgomery; DOI=10.1016/0165-1218(80)90142-1; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=82485; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Genetics: Mutation; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604582_15605017:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3d7d6971f3f36ecb2add99ecf4d0e1e1 |
| ToxValDB ECOTOX | LOEL | =3.2 | mg/kg bw/day | Mouse | injection | short-term; 12 days | short-term | LONG_REF=Mutat. Res.79(1): 7-12 Russell,L.B., and C.S. Montgomery Use of the Mouse Spot Test to Investigate the Mutagenic Potential of Triclosan (Irgasan DP300) 1980; TITLE=Use of the Mouse Spot Test to Investigate the Mutagenic Potential of Triclosan (Irgasan DP300); AUTHOR=Russell,L.B., and C.S. Montgomery; DOI=10.1016/0165-1218(80)90142-1; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=82485; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604582_15605017:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ed070b5d84a69ffb5375b76c58bc658d |
| ToxValDB ECOTOX | LOEL | =100 | mg/kg bw/day | Mouse | injection | short-term; 3 days | short-term | LONG_REF=Arch. Environ. Contam. Toxicol.23(1): 91-98 Kanetoshi,A., E. Katsura, H. Ogawa, T. Ohyama, H. Kaneshima, and T. Miura Acute Toxicity, Percutaneous Absorption and Effects on Hepatic Mixed Function Oxidase Activities of 2,4,4\'-Trichloro-2\'-Hydroxydiphenyl Ether (Irgasan DP300) and Its Chlorinated Derivatives 1992; TITLE=Acute Toxicity, Percutaneous Absorption and Effects on Hepatic Mixed Function Oxidase Activities of 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether (Irgasan DP300) and Its Chlorinated Derivatives; AUTHOR=Kanetoshi,A., E. Katsura, H. Ogawa, T. Ohyama, H. Kaneshima, and T. Miura; DOI=10.1007/BF00226000; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=82487; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Enzyme(s): Aminopyrine n-demethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607565_15607566:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f3e2961c534749c909c7f00c3770ded0 |
| ToxValDB ECOTOX | LOEL | =50 | mg/kg bw/day | Rat | injection | short-term; 3 days | short-term | LONG_REF=Arch. Environ. Contam. Toxicol.23(1): 91-98 Kanetoshi,A., E. Katsura, H. Ogawa, T. Ohyama, H. Kaneshima, and T. Miura Acute Toxicity, Percutaneous Absorption and Effects on Hepatic Mixed Function Oxidase Activities of 2,4,4\'-Trichloro-2\'-Hydroxydiphenyl Ether (Irgasan DP300) and Its Chlorinated Derivatives 1992; TITLE=Acute Toxicity, Percutaneous Absorption and Effects on Hepatic Mixed Function Oxidase Activities of 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether (Irgasan DP300) and Its Chlorinated Derivatives; AUTHOR=Kanetoshi,A., E. Katsura, H. Ogawa, T. Ohyama, H. Kaneshima, and T. Miura; DOI=10.1007/BF00226000; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=82487; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Enzyme(s): para-Nitrophenetole-o-deethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15607922:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=75e58361e8822243fcd8749802f75fc1 |
| ToxValDB ECOTOX | NOEL | =40 | mg/kg bw/day | Mouse | injection | short-term; 2.0833 days | short-term | LONG_REF=Antimicrob. Agents Chemother.47(12): 3859-3866 Sharma,S., T.N.C. Ramya, A. Surolia, and N. Surolia Triclosan as a Systemic Antibacterial Agent in a Mouse Model of Acute Bacterial Challenge 2003; TITLE=Triclosan as a Systemic Antibacterial Agent in a Mouse Model of Acute Bacterial Challenge; AUTHOR=Sharma,S., T.N.C. Ramya, A. Surolia, and N. Surolia; DOI=10.1128/AAC.47.12.3859-3866.2003; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=82484; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX:15594341:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e21bba731b146e8ccdacc8b98af36b6d |
| ToxValDB ECOTOX | NOEL | =0.4 | mmol/kg-day | Rat | injection | short-term; 5 days | short-term | LONG_REF=Chemosphere34(4): 719-730 Hanioka,N., H. Jinno, T. Nishimura, and M. Ando Effect of 2,4,4\'-Trichloro-2\'-Hydroxydiphenyl Ether on Cytochrome P450 Enzymes in the Rat Liver 1997; TITLE=Effect of 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether on Cytochrome P450 Enzymes in the Rat Liver; AUTHOR=Hanioka,N., H. Jinno, T. Nishimura, and M. Ando; DOI=10.1016/s0045-6535(97)00464-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=40088; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Enzyme(s): Aniline hydroxylase|Enzyme(s): Erythromycin N-demethylase|Enzyme(s): NADPH cytochrome C reductase|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594995_15594996_15596616_15596617_15597029_15602161:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9f7ef204875e1adc045b15b86f0554bb |
| ToxValDB ECOTOX | NOEL | =0.2 | mmol/kg-day | Rat | injection | short-term; 5 days | short-term | LONG_REF=Chemosphere34(4): 719-730 Hanioka,N., H. Jinno, T. Nishimura, and M. Ando Effect of 2,4,4\'-Trichloro-2\'-Hydroxydiphenyl Ether on Cytochrome P450 Enzymes in the Rat Liver 1997; TITLE=Effect of 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether on Cytochrome P450 Enzymes in the Rat Liver; AUTHOR=Hanioka,N., H. Jinno, T. Nishimura, and M. Ando; DOI=10.1016/s0045-6535(97)00464-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=40088; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Enzyme(s): Aminopyrine n-demethylase|Enzyme(s): Cytochrome B-5|Enzyme(s): Cytochrome P-450|Enzyme(s): Cytochrome P450 3A2/1|Enzyme(s): Lauric acid monooxygenase|Enzyme(s): Testosterone 6-beta hydroxylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594995_15594996_15596616_15596617_15597029_15602161:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3fbcb2980f6752d4e580ed9e2119a2f6 |
| ToxValDB ECOTOX | NOEL | =50 | mg/kg bw/day | Mouse | injection | short-term; 3 days | short-term | LONG_REF=Arch. Environ. Contam. Toxicol.23(1): 91-98 Kanetoshi,A., E. Katsura, H. Ogawa, T. Ohyama, H. Kaneshima, and T. Miura Acute Toxicity, Percutaneous Absorption and Effects on Hepatic Mixed Function Oxidase Activities of 2,4,4\'-Trichloro-2\'-Hydroxydiphenyl Ether (Irgasan DP300) and Its Chlorinated Derivatives 1992; TITLE=Acute Toxicity, Percutaneous Absorption and Effects on Hepatic Mixed Function Oxidase Activities of 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether (Irgasan DP300) and Its Chlorinated Derivatives; AUTHOR=Kanetoshi,A., E. Katsura, H. Ogawa, T. Ohyama, H. Kaneshima, and T. Miura; DOI=10.1007/BF00226000; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=82487; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Enzyme(s): Aminopyrine n-demethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607565_15607566:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e563b38f62cc4c35246b3ec75b0f85d |
ToxValDB EPA OPP 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA OPP | PAD (RfD) | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15790298_15790300:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fb90f02cd92ba950e13dcaeac39fb2a8 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635354:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c8d10fbe11867a99193e3ca8106d8da |
ToxValDB HEAST 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HEAST | NOEL | =500 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | LONG_REF=U.S. EPA. Health Effects Assessment Summary Tables (Heast). U.S. Environmental Protection Agency, Washington, D.C., 1997. https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=2877.; TITLE=Health Effects Assessment Summary Tables (Heast); AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/62ead7cee4b055edffc0ba74; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=2877; TOXICOLOGICAL_EFFECT=Whole body: Decreased weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=HEAST:15637813:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_827d793d3559b23f3a46784c95e17b4c |
| ToxValDB HEAST | RfD | =4 | mg/kg bw/day | Human | oral | subchronic | Toxicity Value | LONG_REF=U.S. EPA. Health Effects Assessment Summary Tables (Heast). U.S. Environmental Protection Agency, Washington, D.C., 1997. https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=2877.; TITLE=Health Effects Assessment Summary Tables (Heast); AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/62ead7cee4b055edffc0ba74; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=2877; TOXICOLOGICAL_EFFECT=Whole body: Decreased weight in rats; STUDY_GROUP=HEAST:15638084:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f6fb85586e77dbf2e061b12df34025cb |
ToxValDB ToxRefDB 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =168.78 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; TITLE=Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology; AUTHOR=Thevenaz, Dr. phil. II ph; EXTERNAL_SOURCE_ID=2726; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-fatty change|systemic: clinical chemistry-globulins-globulins|systemic: pathology microscopic-liver-hemosiderosis|systemic: clinical chemistry-albumin-albumin|systemic: hematology-platelet-platelet|systemic: organ weight-liver-relative to brain weight|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: clinical chemistry-creatinine-creatinine|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-necrosis|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: pathology microscopic-liver-infiltration cellular|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: pathology microscopic-liver-hypertrophy|systemic: clinical chemistry-urea nitrogen-urea; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15696400_15696401_15696402_15696403:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dabf60214f2919a3f466863c12619db8 |
| ToxValDB ToxRefDB | LEL | =6.48 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; TITLE=Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology; AUTHOR=Thevenaz, Dr. phil. II ph; EXTERNAL_SOURCE_ID=2726; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-infiltration cellular|systemic: pathology microscopic-liver-vacuolization cytoplasmic|systemic: clinical chemistry-albumin-globulin ratio-albumin-globulin ratio|systemic: pathology microscopic-liver-calculus|systemic: hematology-platelet-platelet|systemic: organ weight-liver-absolute|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-liver-hemosiderosis|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-fatty change|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: organ weight-liver-relative to brain weight|systemic: pathology microscopic-liver-necrosis|systemic: clinical chemistry-creatinine-creatinine|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: clinical chemistry-globulins-globulins|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: organ weight-kidney-absolute|systemic: clinical chemistry-urea nitrogen-urea|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: pathology microscopic-liver-hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15696404_15696405_15696406:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9aef7f45f7edeb332f7eed483a8dcb62 |
| ToxValDB ToxRefDB | LEL | =100 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Denning, H.; Sliwa, S.; Willson, G. (1992) Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1. Lab Project Number: RT/3/84. Unpublished Study Prepared By Unilever Research Environmental Safety Lab. 43 P.; TITLE=Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1; AUTHOR=Denning, H.; Sliwa, S.; Willson, G; EXTERNAL_SOURCE_ID=2729; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15696419_15696420_15696421_15696422:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_068061143213e6ee3a4eb3a78f8afca7 |
| ToxValDB ToxRefDB | LEL | >300 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Denning, H.; Sliwa, S.; Willson, G. (1992) Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1. Lab Project Number: RT/3/84. Unpublished Study Prepared By Unilever Research Environmental Safety Lab. 43 P.; TITLE=Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1; AUTHOR=Denning, H.; Sliwa, S.; Willson, G; EXTERNAL_SOURCE_ID=2729; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ToxRefDB_dup_-_15696423_15696424_15696425_15696426:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_994d0d990d3da0f30cf85abeef183fd2 |
| ToxValDB ToxRefDB | LEL | =15 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | developmental | LONG_REF=Schroeder, R. (1992) A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan). Lab Project Number: 91-3666. Unpublished Study Prepared By Bio/Dynamics, Inc. 339 P.; TITLE=A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan); AUTHOR=Schroeder, R; EXTERNAL_SOURCE_ID=2730; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=reproductive: offspring survival early-live fetuses-live fetuses; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB:15696429:M/F:fetusadult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60e4ab419acac4abb28ea52aa1088441 |
| ToxValDB ToxRefDB | LEL | =150 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Schroeder, R. (1992) A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan). Lab Project Number: 91-3666. Unpublished Study Prepared By Bio/Dynamics, Inc. 339 P.; TITLE=A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan); AUTHOR=Schroeder, R; EXTERNAL_SOURCE_ID=2730; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15696430_15696431_15696432_15696433:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d25ff3c462b7befefaedf0d5845de78 |
| ToxValDB ToxRefDB | LOAEL | =135.59 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; TITLE=Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology; AUTHOR=Thevenaz, Dr. phil. II ph; EXTERNAL_SOURCE_ID=2726; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-vacuolization cytoplasmic|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-hemosiderosis|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-fatty change|systemic: organ weight-liver-relative to brain weight|systemic: pathology microscopic-liver-necrosis|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: pathology microscopic-liver-hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15696404_15696405_15696406:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b7827382158696d4c9fae793e181c0a2 |
| ToxValDB ToxRefDB | LOAEL | =300 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Denning, H.; Sliwa, S.; Willson, G. (1992) Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1. Lab Project Number: RT/3/84. Unpublished Study Prepared By Unilever Research Environmental Safety Lab. 43 P.; TITLE=Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1; AUTHOR=Denning, H.; Sliwa, S.; Willson, G; EXTERNAL_SOURCE_ID=2729; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15696419_15696420_15696421_15696422:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e28c0add98753d968f18f61bd503cd34 |
| ToxValDB ToxRefDB | NEL | =8.25 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Thevenaz, Dr. phil. II ph. (1987): Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology. Ciba-Geigy Ltd., Basle, Switzerland. Laboratory Project# 864005. MRID # 44389707. Unpublished.; TITLE=Final Report: FAT 80023: 28-Day Toxicity Study in Mice (Administration in Feed) with Special Reference to Histopathology; AUTHOR=Thevenaz, Dr. phil. II ph; EXTERNAL_SOURCE_ID=2726; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-liver-necrosis|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: pathology microscopic-liver-infiltration cellular|systemic: pathology microscopic-liver-hypertrophy|systemic: clinical chemistry-urea nitrogen-urea|systemic: pathology microscopic-liver-fatty change|systemic: clinical chemistry-globulins-globulins|systemic: pathology microscopic-liver-hemosiderosis|systemic: clinical chemistry-albumin-albumin|systemic: organ weight-liver-relative to brain weight|systemic: hematology-platelet-platelet|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: clinical chemistry-creatinine-creatinine; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15696400_15696401_15696402_15696403:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a2fcc216f898a4c98c24e94fca183c6d |
| ToxValDB ToxRefDB | NEL | =30 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Denning, H.; Sliwa, S.; Willson, G. (1992) Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1. Lab Project Number: RT/3/84. Unpublished Study Prepared By Unilever Research Environmental Safety Lab. 43 P.; TITLE=Triclosan: Effects On Pregnancy And Post-Natal Development In Rats: Volume 1; AUTHOR=Denning, H.; Sliwa, S.; Willson, G; EXTERNAL_SOURCE_ID=2729; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-[other]|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-water consumption-water consumption|systemic: in life observation-clinical signs-defecation (diarrhea); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15696419_15696420_15696421_15696422:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8902b90678f94380f9f38aa8aa793e95 |
| ToxValDB ToxRefDB | NEL | =15 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Schroeder, R. (1992) A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan). Lab Project Number: 91-3666. Unpublished Study Prepared By Bio/Dynamics, Inc. 339 P.; TITLE=A Segment II Teratology Study In Rabbits With Irgacare MP (Triclosan); AUTHOR=Schroeder, R; EXTERNAL_SOURCE_ID=2730; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-resorptions-resorptions; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15696427_15696428:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1083d5e752bb4485d486c2de67eb08f6 |
| ToxValDB ToxRefDB | NEL | =50 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Morseth, S. (1988) Two-Generation Reproduction Study In Rats - FAT 80\'023: HLA Study No. 2386-100. Unpublished Study Prepared By Hazleton Laboratories America, Inc. 986 P.; TITLE=Two-Generation Reproduction Study In Rats - FAT 80\'023; AUTHOR=Morseth, S; EXTERNAL_SOURCE_ID=2732; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15696442_15696443:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5421af31f8a3456d9933336c1a5ba1f6 |
ToxValDB Uterotrophic Hershberger DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | LEL | =4.69 | mg/kg bw/day | Rat | oral | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713388_15713499:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_705cd5f0b99744a3b3cdca98d8b4c1c4 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =7.5 | mg/kg bw/day | Rat | oral | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713388_15713499:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df9066e68ad7a8650beb042ea36f8b31 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =150 | mg/kg bw/day | Rat | oral | short-term; 20 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713625:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6393a68920fb2b5663a188d8980e685f |
Regulatory source 161 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0.3 | % | human | - | - | - | p.119 |
| Regulatory source | - | 1 | - | - | - | - | - | p.69 |
| Regulatory source | - | 1.59 | % | rat | oral | - | - | p.65 |
| Regulatory source | - | 3 | mg/kg bw/d | rabbit | - | 91 days | - | p.29 |
| Regulatory source | - | 3 | - | - | - | - | - | p.69 |
| Regulatory source | - | 5.1 | % | rabbit | oral | 1992d | - | p.63 |
| Regulatory source | - | 9 | - | - | - | - | - | p.59 |
| Regulatory source | - | 10 | mg/kg bw/d | rat | oral | 52-week | - | p.56 |
| Regulatory source | - | 11 | - | - | - | - | - | p.23 |
| Regulatory source | - | 12 | mg/kg bw/day | rat | - | 13 weeks | - | p.119 |
| Regulatory source | - | 12 | mg/kg bw/d | rat | - | 3 weeks | - | p.119 |
| Regulatory source | - | 12 | mg/kg/d | human | - | - | - | p.122 |
| Regulatory source | - | 12 | mg/kg bw/d | rat | - | - | - | p.119 |
| Regulatory source | - | 17 | - | mouse | - | - | - | p.59 |
| Regulatory source | - | 17 | - | rat | - | - | - | p.59 |
| Regulatory source | - | 17 | - | - | - | - | - | p.59 |
| Regulatory source | - | 21 | - | - | - | - | - | p.69 |
| Regulatory source | - | 25 | mg/kg bw/d | dog | - | - | - | p.29 |
| Regulatory source | - | =25 | mg/kg bw/d | rat | oral | - | - | p.62 |
| Regulatory source | - | 25 | mg/kg bw/d | dog | oral | 90 days | - | p.30 |
| Regulatory source | - | 25 | - | mouse | oral | - | - | p.69 |
| Regulatory source | - | 30 | mg/kg bw/d | - | - | 52 weeks | - | p.28 |
| Regulatory source | - | 30 | mg/kg/day | human | oral | chronic | - | p.122 |
| Regulatory source | - | 30 | mg/kg/d | human | - | - | - | p.122 |
| Regulatory source | - | 30 | mg/kg bw/d | - | - | 4-week | - | p.30 |
| Regulatory source | - | 30 | mg/kg bw/d | - | - | 1 year | - | p.30 |
| Regulatory source | - | 30 | mg/kg bw/d | - | oral | 1 year | - | p.34 |
| Regulatory source | - | 38 | % | - | oral | 52- week | - | p.57 |
| Regulatory source | - | 40 | % | - | - | - | - | p.58 |
| Regulatory source | - | =50 | mg/kg bw/d | rat | oral | - | - | p.62 |
| Regulatory source | - | =50 | mg/kg bw/d | - | - | 1992d | - | p.63 |
| Regulatory source | - | 50 | - | rat | oral | - | - | p.69 |
| Regulatory source | - | 50 | - | rabbit | oral | - | - | p.69 |
| Regulatory source | - | 63 | - | - | - | - | - | p.63 |
| Regulatory source | - | 75 | mg/kg | - | - | - | - | p.25 |
| Regulatory source | - | 75 | mg/kg bw/d | rat | oral | 90 days | - | p.26 |
| Regulatory source | - | 75 | mg/kg bw/d | - | - | - | - | p.27 |
| Regulatory source | - | 75 | mg/kg | rat | - | - | - | p.58 |
| Regulatory source | - | 75 | mg/kg bw/d | rat | oral | - | - | p.62 |
| Regulatory source | - | 75 | mg/kg bw/d | mouse | - | - | - | p.62 |
| Regulatory source | - | 75 | mg/kg bw/d | rabbit | oral | - | - | p.62 |
| Regulatory source | - | 80 | mg/kg bw/d | rat | dermal | 28-day | - | p.31 |
| Regulatory source | - | 80 | mg/kg bw/d | - | dermal | 28-day | - | p.31 |
| Regulatory source | - | 80 | mg/kg bw/d | rat | - | - | - | p.66 |
| Regulatory source | - | 82 | % | rat | oral | 10 weeks | - | p.60 |
| Regulatory source | - | 100 | mg/kg bw/d | - | oral | 90 days | - | p.30 |
| Regulatory source | - | 100 | mg/kg bw/d | rabbit | oral | - | - | p.62 |
| Regulatory source | - | 100 | - | rat | oral | - | - | p.69 |
| Regulatory source | - | 100 | mg/kg | rat | oral | 2-week | - | p.106 |
| Regulatory source | - | 100 | mg/kg bw/day | - | - | - | - | p.106 |
| Regulatory source | - | 100 | mg/kg bw/d | - | - | 4-week | - | p.30 |
| Regulatory source | - | 100 | mg/kg | rat | oral | - | - | p.106 |
| Regulatory source | - | 150 | mg/kg bw/d | rabbit | oral | 90 days | - | p.29 |
| Regulatory source | - | 150 | mg/kg bw/d | rabbit | oral | - | - | p.63 |
| Regulatory source | - | =150 | mg/kg bw/d | rat | - | 1992d | - | p.63 |
| Regulatory source | - | 150 | mg/kg bw/d | rat | oral | - | - | p.62 |
| Regulatory source | - | 150 | mg/kg bw/d | rabbit | oral | 1992d | - | p.63 |
| Regulatory source | - | 150 | - | rabbit | oral | - | - | p.69 |
| Regulatory source | - | 160 | mg/kg bw/day | mouse | oral | - | - | p.61 |
| Regulatory source | - | 200 | mg/kg bw/d | - | - | - | - | p.25 |
| Regulatory source | - | 229 | mg/kg bw/d | rat | oral | 10 weeks | - | p.60 |
| Regulatory source | - | 250 | mg/kg bw/d | - | oral | 52- week | - | p.57 |
| Regulatory source | - | 300 | mg/kg bw/d | - | - | 4 weeks | - | p.30 |
| Regulatory source | - | 300 | mg/kg bw/d | rabbit | oral | - | - | p.62 |
| Regulatory source | - | 300 | mg/kg bw/d | - | - | 1 year | - | p.30 |
| Regulatory source | - | 300 | mg/kg bw/day | rat | oral | - | - | p.60 |
| Regulatory source | - | 300 | mg/kg bw/d | rat | oral | - | - | p.62 |
| Regulatory source | - | 300 | - | rat | oral | - | - | p.69 |
| Regulatory source | - | 381 | - | - | - | - | - | p.119 |
| Regulatory source | - | 422 | mg/kg bw/d | rat | - | 52 weeks | - | p.57 |
| Regulatory source | - | 513 | - | - | - | - | - | p.119 |
| Regulatory source | - | 750 | mg/kg bw/d | - | oral | 13 weeks | - | p.27 |
| Regulatory source | - | 900 | mg/kg bw/d | - | oral | 13 weeks | - | p.27 |
| Regulatory source | - | 988 | - | - | - | - | - | p.59 |
| Regulatory source | - | 1000 | ppm | rat | - | - | - | p.26 |
| Regulatory source | - | 1000 | ppm | rat | oral | 104 weeks | - | p.57 |
| Regulatory source | - | 1000 | ppm | rat | - | 0 to Day | - | p.60 |
| Regulatory source | - | 1000 | ppm | - | - | - | - | p.59 |
| Regulatory source | - | 1992 | - | rat | - | - | - | p.59 |
| Regulatory source | carcinogenicity | 10 | mg/kg bw/d | rat | oral | 104-week | carcinogenicity | p.33 |
| Regulatory source | carcinogenicity | 10 | mg/kg bw/d | rat | oral | 1 year | carcinogenicity | p.34 |
| Regulatory source | carcinogenicity | 10 | mg/kg bw/d | mouse | - | 18 Months | carcinogenicity | p.34 |
| Regulatory source | carcinogenicity | 12 | mg/kg bw/d | rat | oral | 13 weeks | carcinogenicity | p.33 |
| Regulatory source | carcinogenicity | 12 | mg/kg bw/d | rat | - | 18 Months | carcinogenicity | p.34 |
| Regulatory source | carcinogenicity | 16 | - | - | - | - | carcinogenicity | p.56 |
| Regulatory source | carcinogenicity | 30 | mg/kg | rat | - | - | carcinogenicity | p.58 |
| Regulatory source | carcinogenicity | ~48 | mg/kg/d | rat | oral | 13 weeks | carcinogenicity | p.33 |
| Regulatory source | carcinogenicity | 48 | mg/kg/d | rat | oral | 1 year | carcinogenicity | p.34 |
| Regulatory source | carcinogenicity | 48 | mg/kg/d | rat | - | 104-week | carcinogenicity | p.34 |
| Regulatory source | carcinogenicity | 75 | mg/kg bw/d | rat | - | 104-week | carcinogenicity | p.34 |
| Regulatory source | carcinogenicity | =75 | mg/kg bw/d | rat | - | 90 weeks | carcinogenicity | p.57 |
| Regulatory source | carcinogenicity | 75 | mg/kg bw/d | - | - | 95 Weeks | carcinogenicity | p.34 |
| Regulatory source | carcinogenicity | 1000 | ppm | rat | - | - | carcinogenicity | p.59 |
| Regulatory source | carcinogenicity | 1192 | - | rat | - | - | carcinogenicity | p.59 |
| Regulatory source | developmental toxicity | 3.3 | - | rat | oral | Developmental | developmental toxicity | p.61 |
| Regulatory source | developmental toxicity | 19 | - | - | - | Developmental | developmental toxicity | p.61 |
| Regulatory source | developmental toxicity | 20 | - | - | - | developmental | developmental toxicity | p.65 |
| Regulatory source | developmental toxicity | 25 | mg/kg | rat | oral | - | developmental toxicity | p.63 |
| Regulatory source | developmental toxicity | 50 | mg/kg | rat | oral | - | developmental toxicity | p.64 |
| Regulatory source | developmental toxicity | 50 | mg/kg | rat | oral | 1992d | developmental toxicity | p.64 |
| Regulatory source | developmental toxicity | 50 | mg/kg | rabbit | oral | 1992d | developmental toxicity | p.64 |
| Regulatory source | developmental toxicity | 50 | mg/kg | mouse | oral | developmental | developmental toxicity | p.65 |
| Regulatory source | developmental toxicity | 65 | mg/kg | rat | oral | Developmental | developmental toxicity | p.61 |
| Regulatory source | developmental toxicity | 100 | mg/kg | rat | oral | - | developmental toxicity | p.64 |
| Regulatory source | developmental toxicity | 150 | mg/kg | rabbit | oral | 1992d | developmental toxicity | p.64 |
| Regulatory source | developmental toxicity | 150 | mg/kg | mouse | oral | developmental | developmental toxicity | p.65 |
| Regulatory source | developmental toxicity | 300 | mg/kg | rat | oral | Developmental | developmental toxicity | p.61 |
| Regulatory source | developmental toxicity | 300 | mg/kg | rat | oral | - | developmental toxicity | p.64 |
| Regulatory source | genotoxicity | 300 | - | rabbit | oral | 91-Day | genotoxicity | p.125 |
| Regulatory source | irritation | 12 | mg/kg bw/day | rat | dermal | - | irritation | p.21 |
| Regulatory source | irritation | 12 | mg/kg bw/d | rat | oral | - | irritation | p.120 |
| Regulatory source | irritation | 24 | mg/kg | rat | dermal | - | irritation | p.21 |
| Regulatory source | irritation | 24 | mg/kg bw | mouse | dermal | 14 days | irritation | p.22 |
| Regulatory source | irritation | 24 | mg/kg bw | rat | dermal | 14 days | irritation | p.22 |
| Regulatory source | irritation | 60 | mg/kg bw/d | rat | dermal | - | irritation | p.21 |
| Regulatory source | repeated dose toxicity | 3 | mg/kg bw/day | rabbit | oral | Subchronic | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 4 | % | - | dermal | Sub-Chronic | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 10 | - | - | dermal | - | repeated dose toxicity | p.22 |
| Regulatory source | repeated dose toxicity | 12 | mg/kg bw | rat | inhalation | 21 days | repeated dose toxicity | p.22 |
| Regulatory source | repeated dose toxicity | 12 | mg/kg bw/d | rat | oral | 13-week | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 12 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 13 | - | - | oral | Sub-Chronic | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 21 | - | mouse | - | developmental | repeated dose toxicity | p.68 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg bw/day | dog | oral | Subchronic | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg | rat | - | developmental | repeated dose toxicity | p.121 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg | mouse | oral | Subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 30 | mg/kg bw/d | rat | dermal | Sub-Chronic | repeated dose toxicity | p.30 |
| Regulatory source | repeated dose toxicity | 30 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 48 | mg/kg bw/d | rat | oral | 95-week | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 50 | ppm | rat | oral | 14-day | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg | rat | - | developmental | repeated dose toxicity | p.68 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/day | rat | oral | Subchronic | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/day | rabbit | oral | Subchronic | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/d | - | oral | subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/d | human | oral | subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/d | - | oral | Sub-Chronic | repeated dose toxicity | p.26 |
| Regulatory source | repeated dose toxicity | =80 | mg/kg/day | rat | dermal | Sub-Chronic | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 80 | mg/kg bw/d | - | dermal | Sub-Chronic | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 169 | mg/kg | mouse | oral | 28 days | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/d | rat | oral | Subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/d | - | oral | Subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 350 | mg/kg | rat | - | developmental | repeated dose toxicity | p.121 |
| Regulatory source | repeated dose toxicity | 1000 | ppm | - | oral | Subchronic | repeated dose toxicity | p.25 |
| Regulatory source | repeated dose toxicity | 1000 | ppm | rat | oral | Subchronic | repeated dose toxicity | p.34 |
| Regulatory source | repeated dose toxicity | 1000 | ppm | - | oral | Sub-Chronic | repeated dose toxicity | p.26 |
| Regulatory source | repeated dose toxicity | 2000 | - | mouse | - | 14 days | repeated dose toxicity | p.68 |
| Regulatory source | reproductive toxicity | 2 | - | rat | - | - | reproductive toxicity | p.59 |
| Regulatory source | reproductive toxicity | 8 | mg/kg bw | rat | oral | - | reproductive toxicity | p.65 |
| Regulatory source | reproductive toxicity | 65 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.60 |
| Regulatory source | reproductive toxicity | 200 | mg/kg | rat | - | - | reproductive toxicity | p.67 |
| Regulatory source | reproductive toxicity | 300 | mg/kg bw/d | rat | oral | - | reproductive toxicity | p.60 |
| Regulatory source | reproductive toxicity | 350 | mg/kg | rat | - | developmental | reproductive toxicity | p.121 |
| Regulatory source | reproductive toxicity | 1000 | ppm | rat | - | developmental | reproductive toxicity | p.59 |
| Regulatory source | reproductive toxicity | 1000 | ppm | - | - | - | reproductive toxicity | p.60 |
| Regulatory source | reproductive toxicity | 1192 | - | rat | oral | Developmental | reproductive toxicity | p.69 |
| Regulatory source | reproductive toxicity | 1978 | - | mouse | - | - | reproductive toxicity | p.66 |
| Regulatory source | reproductive toxicity | 1987 | - | rat | - | Developmental | reproductive toxicity | p.67 |
| Regulatory source | reproductive toxicity | 1987 | - | rat | oral | Developmental | reproductive toxicity | p.67 |
| Regulatory source | reproductive toxicity | 3000 | ppm | rat | oral | - | reproductive toxicity | p.60 |
| Regulatory source | reproductive toxicity | 3000 | ppm | rat | - | 0 to Day | reproductive toxicity | p.60 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 4NM5039Y5X | UNII | - | - | - | chemical | - |