Tridecapeptide-1

INCI: TRIDECAPEPTIDE-1

CAS Number
No standardized CAS assigned (proprietary synthetic peptide)
Function
Anti-aging/anti-wrinkle peptide — mimics Botox by targeting acetylcholine receptors to relax facial muscles; reduces expression lines
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted as cosmetic ingredient; no specific restrictions (cosmetic claim, not drug)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Used at very low concentrations (ppm levels). Mechanism targets neuromuscular signaling — cosmetic-only claims must be maintained to avoid drug classification . No CIR or SCCS formal review published. Verify supplier COA and stability data — peptide degradation may affect both efficacy and safety.

⚠️
Concern Level: Low

Frequently Asked Questions

Is Tridecapeptide-1 safe in cosmetics?

Used at very low concentrations (ppm levels). Mechanism targets neuromuscular signaling — cosmetic-only claims must be maintained to avoid drug classification . No CIR or SCCS formal review published. Verify supplier COA and stability data — peptide degradation may affect both efficacy and safety. The EU classifies Tridecapeptide-1 as "permitted". Safety rating: GOOD.

Is Tridecapeptide-1 allowed in the EU?

Tridecapeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tridecapeptide-1 do in cosmetics?

Tridecapeptide-1 functions as: Anti-aging/anti-wrinkle peptide — mimics Botox by targeting acetylcholine receptors to relax facial muscles; reduces expression lines. It is classified as a cosmetic ingredient in our database. CAS number: No standardized CAS assigned (proprietary synthetic peptide).

What is the Margin of Safety for Tridecapeptide-1?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

📱

Is Tridecapeptide-1 in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tridecapeptide-1 in your formulation.