NOAEL Studies
Cosmetic Ingredient
Triethylamine NOAEL Studies
INCI: TRIETHYLAMINE
CAS: 121-44-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | 45 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=03d57ee0-515e-4ebb-bf62-8235989b6474.i6z; document=92fd8ae3-587a-4b89-ba27-580b589c270c_03d57ee0-515e-4ebb-bf62-8235989b6474.i6d; document_key=92fd8ae3-587a-4b89-ba27-580b589c270c/03d57ee0-515e-4ebb-bf62-8235989b6474; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=5518e62a-c6f2-478b-8164-937fb2515fcd |
| ECHA | NOAEL | 135 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=03d57ee0-515e-4ebb-bf62-8235989b6474.i6z; document=92fd8ae3-587a-4b89-ba27-580b589c270c_03d57ee0-515e-4ebb-bf62-8235989b6474.i6d; document_key=92fd8ae3-587a-4b89-ba27-580b589c270c/03d57ee0-515e-4ebb-bf62-8235989b6474; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=afa9165a-5e48-4d57-97b8-71cddaf2f110 |
| ECHA | NOAEL | 40 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=03d57ee0-515e-4ebb-bf62-8235989b6474.i6z; document=61b809d3-91c4-4ca4-9469-8d884f69fdef_03d57ee0-515e-4ebb-bf62-8235989b6474.i6d; document_key=61b809d3-91c4-4ca4-9469-8d884f69fdef/03d57ee0-515e-4ebb-bf62-8235989b6474; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=cfde6609-5486-4c0e-8f38-1eec88a369e7 |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=03d57ee0-515e-4ebb-bf62-8235989b6474.i6z; document=136157a1-927f-40de-aab9-aeb10b14467a_03d57ee0-515e-4ebb-bf62-8235989b6474.i6d; document_key=136157a1-927f-40de-aab9-aeb10b14467a/03d57ee0-515e-4ebb-bf62-8235989b6474; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=b958f199-82e6-4847-a16f-ef13c4ed0fb1 |
| ECHA | LEL | =500 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/3/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796219_15796514_15796515_15798272:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_947ec488101563085478099372526b3d |
| ECHA | LEL | =1000 | mg/m3 | Rat | inhalation | short-term; 2 weeks | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15827182:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc0ad8446f90ce4f6f9cd50ec6f753a4 |
| ECHA | LEL | =50 | mg/m3 | Rat | inhalation | acute; 3 hours | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15827896:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d12afdb589298743a34214428f05dbfc |
| ECHA | LEL | =103.47 | mg/m3 | Rat | inhalation | short-term; 30 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827922_15827923:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23560bb499343c2b8b6795e24aff3cc6 |
| ECHA | LEL | =1034.7 | mg/m3 | Rat | inhalation | short-term; 30 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827922_15827923:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a42043a8d7dca74f6407a2850dee350f |
| ECHA | LEL | =3 | mg/m3 | Mouse | inhalation | acute; 3 hours | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15829118:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c1f169d7bbfb706aaf157868d8723d1 |
| ECHA | LEL | =4223 | mg/kg bw/day | Rat | oral | subchronic; 11 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21c9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/2?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15845938:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38f30ea5576fb5a4ba3fb3ed8856d214 |
| ECHA | LEL | =210 | mg/kg bw/day | Rat | oral | chronic; 30 weeks | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21cd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/2?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15846090:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bbe1064293360b8e6e755a9fbfc02bb4 |
| ECHA | LOAEC | =198.662 | mg/m3 | Rabbit | inhalation | acute; 7 hours | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15828054:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7007267294076b65b8eee929b659eef0 |
| ECHA | LOAEC | =210 | mg/m3 | Rabbit | inhalation | subchronic; 6 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15829132:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1db30f27b83d491f99c4aac592e127ad |
| ECHA | NOAEC | =1020 | mg/m3 | Rat | inhalation | chronic; 28 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828847_15828848_15828849:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c1df1e8cfcb913b8b9431130c90b753 |
| ECHA | NOAEC | =103.3 | mg/m3 | Rat | inhalation | chronic; 28 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828847_15828848_15828849:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6213aa015706fedbd9be1993f9f71444 |
| ECHA | NOAEL | =1033 | mg/m3 | Rat | inhalation | short-term; 10 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/3?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15827846:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e42a0d94c43089eacd916b2590501c4 |
| ECHA | NOAEL | =0.1 | mg/kg bw/day | Rat | oral | chronic; 6 months | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18127/7/6/2?documentUUID=03d57ee0-515e-4ebb-bf62-8235989b6474; YEAR=1949; ORIGINAL_YEAR=1949; STUDY_GROUP=ECHA IUCLID:15832632:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_16c30efe48e51bb196fbda6aa37e00ff |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL (HEC) | =19.5 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=6b6df87af5caad42; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 1.95e1 mg/m^3; system=Respiratory; basis=Inflammation of the nasal passage; point_of_departure=NOAEL (HEC): 1.95e1 mg/m^3; composite_uf=3000; confidence=Low; dtxsid=DTXSID3024366; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=520; rfc_last_updated=04/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0520_summary.pdf |
| Regulatory source | RfC | =0.007 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=a89c57571c0a0dae; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=7e-3; system=Respiratory; basis=Inflammation of the nasal passage; point_of_departure=NOAEL (HEC): 1.95e1 mg/m^3; composite_uf=3000; confidence=Low; dtxsid=DTXSID3024366; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=520; rfc_last_updated=04/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0520_summary.pdf |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 14.4601 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2031; Record_ID=acute_inhalation_2557; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3024366; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.4601; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14938/7/3/3/?documentUUID=e9b0636c-9701-472a-997d-e54aa47360d0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3024366; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3024366 |
| NTP ICE acute inhalation | LC50 | 10.9 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2032; Record_ID=acute_inhalation_2566; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3024366; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=10.9; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14938/7/3/3/?documentUUID=5ab82cff-5026-4e04-8173-740c77c5eb55; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3024366; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3024366 |
| NTP ICE acute inhalation | LC50 | 14.441 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2033; Record_ID=acute_inhalation_2572; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3024366; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.441; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14938/7/3/3/?documentUUID=5a350151-dbd7-4bc1-b011-5e230955e52f; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3024366; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3024366 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =730 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1647; row=5758; data_type=In Vivo; mixture=Chemical; chemical_name=Triethylamine; preferred_name=Triethylamine; dtxsid=DTXSID3024366; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3024366; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3024366; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =460 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1646; row=5759; data_type=In Vivo; mixture=Chemical; chemical_name=Triethylamine; preferred_name=Triethylamine; dtxsid=DTXSID3024366; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3024366; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3024366; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1030 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1649; row=5760; data_type=In Vivo; mixture=Chemical; chemical_name=Triethylamine; preferred_name=Triethylamine; dtxsid=DTXSID3024366; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3024366; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3024366; source_file=acute_oral.xlsx |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =10 | mg/m3 | Human | inhalation | acute; 8 hours | clinical | LONG_REF=Akesson B, Floren I, Skerfving S. Visual disturbances after experimental human exposure to triethylamine. Br J Ind Med 1985;42:848-850; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=visual disturbances, eye irritation, and transient corneal edema; STUDY_GROUP=Cal OEHHA REL derivations:15951985:-:-healthy volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1400e26973cfc1b4b271add1b34c0664 |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =103.47 | mg/m3 | Rat | inhalation | chronic; 28 weeks | chronic | LONG_REF=Lynch DW, Moorman TR, Lewis P, Stober P, Hamlin R, and Scheuler RL. 1990. Subchronic inhalation of triethylamine vapor in Fischer-344 rats: Organ system toxicity. Toxicol. Ind. Health. 6(3/4):403-414.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Eye effects in rats and humans; STUDY_GROUP=Cal OEHHA REL derivations:15952153:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f6c8d725e6f8a0bb5d84b4f69951001 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =49665.5 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15520624:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56a2961edb76074e165992b11906a425 |
ToxValDB EU SCOEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | LOAEL | =6.20819 | mg/m3 | Human | inhalation | acute; 4 hours | clinical | LONG_REF=Jarvinen, P., Engstrom, Riihimaki, V., Ruusuvaara, P. and Setala, K. (1999). Effects of experimental exposure to triethylamine on vision and the eye. Occup. Environ. Med. 56, 1-5.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d3927; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/048_triethylamine_oel_en.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=slight visual disturbances; STUDY_GROUP=EU SCOEL_dup_-_15952569_15952570:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce3a4e5b5ce7be8d2a2666aa1896f829 |
| ToxValDB EU SCOEL | NOAEL | =2.89716 | mg/m3 | Human | inhalation | acute; 4 hours | clinical | LONG_REF=Jarvinen, P., Engstrom, Riihimaki, V., Ruusuvaara, P. and Setala, K. (1999). Effects of experimental exposure to triethylamine on vision and the eye. Occup. Environ. Med. 56, 1-5.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d3927; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/048_triethylamine_oel_en.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=slight visual disturbances; STUDY_GROUP=EU SCOEL_dup_-_15952569_15952570:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_388022038e7a3722aedb5e743a0c1226 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =8.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635381_15635382:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a45459dda6519dc9c7948d391c18a848 |
ToxValDB IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | NOAEL | =1022.2 | mg/m3 | Rat | inhalation | chronic; 28 weeks | chronic | LONG_REF=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler. 1990. Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity. Toxicol. Indus. Health. 6(3/4): 403-414.; TITLE=Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity; AUTHOR=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b57; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=520; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15645530_15645531_15645532:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fa13616eefbf337ccce1b0002d97afc0 |
| ToxValDB IRIS | NOAEL (ADJ) | =182.5 | mg/m3 | Rat | inhalation | chronic; 28 weeks | chronic | LONG_REF=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler. 1990. Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity. Toxicol. Indus. Health. 6(3/4): 403-414.; TITLE=Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity; AUTHOR=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b57; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=520; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15645530_15645531_15645532:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ef8047da969e98f05c779e0e29b429f2 |
| ToxValDB IRIS | NOAEL (HEC) | =19.5 | mg/m3 | Rat | inhalation | chronic; 28 weeks | chronic | LONG_REF=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler. 1990. Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity. Toxicol. Indus. Health. 6(3/4): 403-414.; TITLE=Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity; AUTHOR=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b57; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=520; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15645530_15645531_15645532:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3297bdec87f8ace71eb1acdc3acdff50 |
| ToxValDB IRIS | RfC | =0.007 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler. 1990. Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity. Toxicol. Indus. Health. 6(3/4): 403-414.; TITLE=Subchronic inhalation of triethylamine vapor in Fisher-344 rats: Organ system toxicity; AUTHOR=Lynch D.W., W.J. Moorman, T.R. Lewis, P. Stober, R. Hamlin, and R.L. Schueler; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b57; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=520; TOXICOLOGICAL_EFFECT=Inflammation of the nasal passage in male/female rats; STUDY_GROUP=IRIS:15645533:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_51a73ade77659d4aac2ef0f740fabf7e |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | VOU728O6AY | UNII | - | - | - | chemical | - |