Is Trihydroxychalcone safe in cosmetics?
Trihydroxychalcone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Trihydroxychalcone
INCI: TRIHYDROXYCHALCONE
Trihydroxychalcone (CAS 961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone)) is a cosmetic cosmetic ingredient functioning as Skin conditioning, antioxidant (chalcone flavonoid, also known as. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
CAS Number
961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone)
View industrial chemical safety profile →
Function
Skin conditioning, antioxidant (chalcone flavonoid, also known as isoliquiritigenin)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; naturally occurring in licorice root; no specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trihydroxychalcone.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Trihydroxychalcone — not a computed safety verdict. See the sourced toxicological data above.
Frequently Asked Questions
Is Trihydroxychalcone allowed in the EU?
Trihydroxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trihydroxychalcone do in cosmetics?
Trihydroxychalcone functions as: Skin conditioning, antioxidant (chalcone flavonoid, also known as isoliquiritigenin). It is classified as a cosmetic ingredient in our database. CAS number: 961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone).
Compliance Tools
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