Trihydroxychalcone

INCI: TRIHYDROXYCHALCONE

CAS Number
961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone)
Function
Skin conditioning, antioxidant (chalcone flavonoid, also known as isoliquiritigenin)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics; naturally occurring in licorice root; no specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS Skin Irrit. 2 (100% of notifications) and Eye Irrit. 2 (100%); respiratory irritation potential (H335) at 80% notification rate; use concentration should be carefully controlled; eye-area products require extra caution

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Concern Level: Moderate

Frequently Asked Questions

Is Trihydroxychalcone safe in cosmetics?

GHS Skin Irrit. 2 (100% of notifications) and Eye Irrit. 2 (100%); respiratory irritation potential (H335) at 80% notification rate; use concentration should be carefully controlled; eye-area products require extra caution The EU classifies Trihydroxychalcone as "permitted". Safety rating: MODERATE.

Is Trihydroxychalcone allowed in the EU?

Trihydroxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trihydroxychalcone do in cosmetics?

Trihydroxychalcone functions as: Skin conditioning, antioxidant (chalcone flavonoid, also known as isoliquiritigenin). It is classified as a cosmetic ingredient in our database. CAS number: 961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone).

What is the Margin of Safety for Trihydroxychalcone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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