Trihydroxydihydrochalcone

INCI: TRIHYDROXYDIHYDROCHALCONE

CAS Number
Not widely published; structurally a reduced (dihydro) form of trihydroxychalcone
Function
Skin conditioning, antioxidant (dihydrochalcone flavonoid)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics; no specific restriction; no CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Data gap โ€” no published cosmetic safety assessment; extrapolation from trihydroxychalcone GHS data suggests caution for skin/eye irritation; supplier toxicological dossier required for CPSR

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Concern Level: High

Frequently Asked Questions

Is Trihydroxydihydrochalcone safe in cosmetics?

Data gap โ€” no published cosmetic safety assessment; extrapolation from trihydroxychalcone GHS data suggests caution for skin/eye irritation; supplier toxicological dossier required for CPSR The EU classifies Trihydroxydihydrochalcone as "permitted". Safety rating: MODERATE.

Is Trihydroxydihydrochalcone allowed in the EU?

Trihydroxydihydrochalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trihydroxydihydrochalcone do in cosmetics?

Trihydroxydihydrochalcone functions as: Skin conditioning, antioxidant (dihydrochalcone flavonoid). It is classified as a cosmetic ingredient in our database. CAS number: Not widely published; structurally a reduced (dihydro) form of trihydroxychalcone.

What is the Margin of Safety for Trihydroxydihydrochalcone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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