Tripeptide-9

INCI: TRIPEPTIDE-9

CAS Number
Not publicly listed (derivative Tripeptide-9 Citrulline is registered separately in CosIng)
Function
Skin conditioning — related to collagen-stimulating matrikine peptides
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status restricted
US Notes Not specifically restricted; CIR has reviewed the broader tripeptide-1 class but not Tripeptide-9 specifically

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Relies on read-across from CIR-reviewed tripeptide-1 class data. Specific sequence and bioactivity should be confirmed with supplier. Acetyl Tetrapeptide-9 (a tetrapeptide derivative) has more published data than the base Tripeptide-9.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Tripeptide-9 safe in cosmetics?

Relies on read-across from CIR-reviewed tripeptide-1 class data. Specific sequence and bioactivity should be confirmed with supplier. Acetyl Tetrapeptide-9 (a tetrapeptide derivative) has more published data than the base Tripeptide-9. The EU classifies Tripeptide-9 as "permitted". Safety rating: MODERATE.

Is Tripeptide-9 allowed in the EU?

Tripeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tripeptide-9 do in cosmetics?

Tripeptide-9 functions as: Skin conditioning — related to collagen-stimulating matrikine peptides. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly listed (derivative Tripeptide-9 Citrulline is registered separately in CosIng).

What is the Margin of Safety for Tripeptide-9?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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