Tripterygium Wilfordii Root Extract

INCI: TRIPTERYGIUM WILFORDII ROOT EXTRACT

CAS Number
Not specifically assigned (botanical extract)
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿšจ Root extract contains the highest concentrations of triptolide (reproductive toxicant, hepatotoxin). Significantly more hazardous profile than callus extract (\#2). Oral ingestion of the root is associated with serious adverse effects. Without strict standardization limits, this ingredient is high-risk for cosmetic use

โš ๏ธ
Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Tripterygium Wilfordii Root Extract safe in cosmetics?

๐Ÿšจ Root extract contains the highest concentrations of triptolide (reproductive toxicant, hepatotoxin). Significantly more hazardous profile than callus extract (\#2). Oral ingestion of the root is associated with serious adverse effects. Without strict standardization limits, this ingredient is high-risk for cosmetic use The EU classifies Tripterygium Wilfordii Root Extract as "permitted". Safety rating: POOR.

Is Tripterygium Wilfordii Root Extract allowed in the EU?

Tripterygium Wilfordii Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tripterygium Wilfordii Root Extract do in cosmetics?

Tripterygium Wilfordii Root Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not specifically assigned (botanical extract).

What is the Margin of Safety for Tripterygium Wilfordii Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Tripterygium Wilfordii Root Extract in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tripterygium Wilfordii Root Extract in your formulation.