Trisodium Glycyrrhizate

INCI: TRISODIUM GLYCYRRHIZATE

CAS Number
31427-65-1
Function
Skin conditioning; fragrance (perfuming agent); anti-inflammatory (licorice derivative)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics; glycyrrhizic acid salts are GRAS for food use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

High systemic doses of glycyrrhizin can cause pseudoaldosteronism (hypertension, hypokalemia) โ€” cosmetic topical levels not a concern; fragrance allergen labeling may apply in EU

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Trisodium Glycyrrhizate safe in cosmetics?

High systemic doses of glycyrrhizin can cause pseudoaldosteronism (hypertension, hypokalemia) โ€” cosmetic topical levels not a concern; fragrance allergen labeling may apply in EU The EU classifies Trisodium Glycyrrhizate as "permitted". Safety rating: GOOD.

Is Trisodium Glycyrrhizate allowed in the EU?

Trisodium Glycyrrhizate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trisodium Glycyrrhizate do in cosmetics?

Trisodium Glycyrrhizate functions as: Skin conditioning; fragrance (perfuming agent); anti-inflammatory (licorice derivative). It is classified as a cosmetic ingredient in our database. CAS number: 31427-65-1.

What is the Margin of Safety for Trisodium Glycyrrhizate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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