Poor Cosmetic Ingredient GHS Classified

Trisodium NTA

INCI: TRISODIUM NTA (TRISODIUM NITRILOTRIACETATE)

CAS Number
5064-31-3
Function
Chelating agent; sequestering agent
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 5%
🇺🇸 US Status permitted
US Notes No specific FDA cosmetic ban; however, carcinogenicity classification limits practical use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.
Long-term Exposure Effects
This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

EU Carc. Cat. 2 classification; nephrotoxic (kidney tubular damage, hyperplasia); LOAEL 187 mg/kg/day oral; eye irritant (R36); strongly basic pH; not used directly in cosmetics per industry data

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Concern Level: High

Regulatory Flags

eu_banned_cosmetics fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Trisodium NTA safe in cosmetics?

EU Carc. Cat. 2 classification; nephrotoxic (kidney tubular damage, hyperplasia); LOAEL 187 mg/kg/day oral; eye irritant (R36); strongly basic pH; not used directly in cosmetics per industry data The EU classifies Trisodium NTA as "permitted". Safety rating: POOR.

Is Trisodium NTA allowed in the EU?

Trisodium NTA EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Trisodium NTA do in cosmetics?

Trisodium NTA functions as: Chelating agent; sequestering agent. It is classified as a cosmetic ingredient in our database. CAS number: 5064-31-3.

What is the Margin of Safety for Trisodium NTA?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Trisodium NTA compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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